Download or read book Drug Discrimination written by Richard A. Glennon and published by John Wiley & Sons. This book was released on 2011-08-23 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Download or read book The Behavioral Neuroscience of Drug Discrimination written by Joseph H. Porter and published by Springer. This book was released on 2018-08-30 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has provided immense translational value for learning about the mechanisms responsible for drug effects in humans.
Download or read book Problems of Drug Dependence written by College on Problems of Drug Dependence (U.S.). Scientific Meeting and published by . This book was released on 1999 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sensory Discrimination Tests and Measurements written by Jian Bi and published by John Wiley & Sons. This book was released on 2015-10-12 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensory testing and measurement are the main functions of sensory analysis. In recent years, the sensory and consumer field has evolved to include both difference testing and similarity testing, and new sensory discrimination methods such as the tetrads have received more attention in the literature. This second edition of Sensory Discrimination Tests and Measurements is updated throughout and responds to these changes and includes: A wide range of sensory measurements: Measurements of sensory effect (d', R-index and Gini-index); Measurements of performance of trained sensory panel (Intraclass correlation coefficients and Cronbachs coefficient alpha); Measurements of relative importance of correlated sensory and consumer attributes (drivers of consumer liking or purchase intent); Measurements of consumer emotions and psychographics; Measurements of time-intensity; Measurements of sensory thresholds; Measurements of sensory risk with negative sensory effects (Benchmark Dose, BMD, methodology) Measurements of sensory shelf life (SSL). A balanced introduction of sensory discrimination tests including difference tests and similarity tests. Bayesian approach to sensory discrimination tests. Modified and multiple-sample discrimination tests. Replicated discrimination tests using the beta-binomial (BB), corrected beta-binomial (CBB), and Dirichlet-multinomial (DM) models. Sensory discrimination methods including the tetrads and the M+N. R and S-Plus codes for all the measurements and tests introduced in the book. Mainly intended for researchers and practitioners in the sensory and consumer field, the book is a useful reference for modern sensory analysis and consumer research, especially for sensometrics.
Download or read book Testing for Abuse Liability of Drugs in Humans written by Marian W. Fischman and published by . This book was released on 1989 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Download or read book Federal Register written by and published by . This book was released on 1996-08-28 with total page 1208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Abuse and Drug Abuse Research written by Education and Welfare U.S. Department of Health and published by . This book was released on 1971 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Marihuana and Health written by and published by . This book was released on 1975 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Smoking and Health Bulletin written by and published by . This book was released on 1987 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drugs and the Neuroscience of Behavior written by Adam Prus and published by SAGE Publications. This book was released on 2020-08 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs and the Neuroscience of Behavior presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. Author Adam Prus provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology including new drugs and recent trends in drug use. Empirically supported pedagogical features offer students the opportunity to reflect on what they read to ensure understanding before progressing to new content. The Third Edition includes a new chapter on depressants and discussions of major topics such as the opioid epidemic, the risks associated with vaping, and MDMA-assisted psychotherapy for PTSD. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
Download or read book Application of Basic Neuroscience to Child Psychiatry written by S.I. Deutsch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea for this book developed during the course of several discussions among the editors while we were working together as staff scientists in the laboratories of the Clinical Neuro science Branch of the National Institute of Mental Health. It was a happy coincidence that the three of us, child psychiatrists with predominantly clinical interests, selected a collaborative bench research project involving neurotransmitter receptor characterization and regulation. We appreciated the relevance of our work to child psychiatry and wished for a forum to share the excitement we enjoyed in the laboratory with our clinical colleagues. Moreover, it seemed to us that much of the pharmacological research in child psychiatry proceeded on an empirical basis, often without a compelling neurochemical rationale. This could reflect the paucity of neurochemical data that exists in child psychiatry and the very limited understanding of the pathophysiology in most psychiatric disorders that occur in childhood. Also, we bemoaned the fact that there was a virtual absence of meaningful interchange between clinical investigators in child psychiatry and their colleagues in the neurosciences. We believed that an edited book appealing to clinicians and basic scientists could serve as an initial effort to foster interchange between them. The editors wish to emphasize that this book is viewed as only a beginning in the process of interchange that must take place.
Download or read book Measuring Racial Discrimination written by National Research Council and published by National Academies Press. This book was released on 2004-06-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many racial and ethnic groups in the United States, including blacks, Hispanics, Asians, American Indians, and others, have historically faced severe discriminationâ€"pervasive and open denial of civil, social, political, educational, and economic opportunities. Today, large differences among racial and ethnic groups continue to exist in employment, income and wealth, housing, education, criminal justice, health, and other areas. While many factors may contribute to such differences, their size and extent suggest that various forms of discriminatory treatment persist in U.S. society and serve to undercut the achievement of equal opportunity. Measuring Racial Discrimination considers the definition of race and racial discrimination, reviews the existing techniques used to measure racial discrimination, and identifies new tools and areas for future research. The book conducts a thorough evaluation of current methodologies for a wide range of circumstances in which racial discrimination may occur, and makes recommendations on how to better assess the presence and effects of discrimination.
Download or read book Problems of Drug Dependence 1994 written by and published by . This book was released on 1994 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Problems of Drug Dependence 1994 Abstracts written by College on Problems of Drug Dependence (U.S.). Scientific Meeting and published by . This book was released on 1995 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Cocaine written by Ronald P. Hammer, Jr. and published by CRC Press. This book was released on 1995-07-17 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation. This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.
Download or read book Drug Discrimination and State Dependent Learning written by Beng T. Ho and published by . This book was released on 1978 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
