Download or read book A Conspiracy of Cells written by Michael Gold and published by State University of New York Press. This book was released on 1985-10-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Conspiracy of Cells presents the first full account of one of medical science's more bizarre and costly mistakes. On October 4, 1951, a young black woman named Henrietta Lacks died of cervical cancer. That is, most of Henrietta Lacks died. In a laboratory dish at the Johns Hopkins Medical Center in Baltimore, a few cells taken from her fatal tumor continued to live--to thrive, in fact. For reasons unknown, her cells, code-named "HeLa," grew more vigorously than any other cells in culture at the time. Long-time science reporter Michael Gold describes in graphic detail how the errant HeLa cells spread, contaminating and overwhelming other cell cultures, sabotaging research projects, and eluding detection until they had managed to infiltrate scientific laboratories worldwide. He tracks the efforts of geneticist Walter Nelson-Rees to alert a sceptical scientific community to the rampant HeLa contamination. And he reconstructs Nelson-Rees's crusade to expose the embarrassing mistakes and bogus conclusions of researchers who unknowingly abetted HeLa's spread.

Download or read book A Conspiracy of Cells written by Michael Gold and published by SUNY Press. This book was released on 1986-01-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Conspiracy of Cells presents the first full account of one of medical science's more bizarre and costly mistakes. On October 4, 1951, a young black woman named Henrietta Lacks died of cervical cancer. That is, most of Henrietta Lacks died. In a laboratory dish at the Johns Hopkins Medical Center in Baltimore, a few cells taken from her fatal tumor continued to live--to thrive, in fact. For reasons unknown, her cells, code-named "HeLa," grew more vigorously than any other cells in culture at the time. Long-time science reporter Michael Gold describes in graphic detail how the errant HeLa cells spread, contaminating and overwhelming other cell cultures, sabotaging research projects, and eluding detection until they had managed to infiltrate scientific laboratories worldwide. He tracks the efforts of geneticist Walter Nelson-Rees to alert a sceptical scientific community to the rampant HeLa contamination. And he reconstructs Nelson-Rees's crusade to expose the embarrassing mistakes and bogus conclusions of researchers who unknowingly abetted HeLa's spread.

Download or read book The Immortal Life of Henrietta Lacks written by Rebecca Skloot and published by Crown. This book was released on 2010-02-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Download or read book A Conspiracy of Truths written by Alexandra Rowland and published by Gallery / Saga Press. This book was released on 2019-07-23 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wrongfully imprisoned storyteller spins stories from his jail cell that just might have the power to save him—and take down a corrupt government. Arrested on accusations of witchcraft and treason, Chant finds himself trapped in a cold, filthy jail cell in a foreign land. With only his advocate, the unhelpful and uninterested Consanza, he quickly finds himself cast as a bargaining chip in a brewing battle between the five rulers of this small, backwards, and petty nation. Or, at least, that's how he would tell the story. In truth, Chant has little idea of what is happening outside the walls of his cell, but he must quickly start to unravel the puzzle of his imprisonment before they execute him for his alleged crimes. But Chant is no witch—he is a member of a rare and obscure order of wandering storytellers. With no country to call his home, and no people to claim as his own, all Chant has is his wits and his apprentice, a lad more interested in wooing handsome shepherds than learning the ways of the world. And yet, he has one great power: his stories in the ears of the rulers determined to prosecute him for betraying a nation he knows next to nothing about. The tales he tells will topple the Queens of Nuryevet and just maybe, save his life.

Download or read book A Conspiracy Of Cells written by R. Grant Steen and published by Da Capo Press, Incorporated. This book was released on 1993 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on over 2000 primary sources, Dr. Steen examines fourteen of the most common cancers, reveals what today's researchers know about cancer, and encourages patients to take active roles in combating their own diseases.

Download or read book Culturing Life written by Hannah Landecker and published by Harvard University Press. This book was released on 2010-03-30 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: How did cells make the journey, one we take so much for granted, from their origin in living bodies to something that can be grown and manipulated on artificial media in the laboratory, a substantial biomass living outside a human body, plant, or animal? This is the question at the heart of Hannah Landecker's book. She shows how cell culture changed the way we think about such central questions of the human condition as individuality, hybridity, and even immortality and asks what it means that we can remove cells from the spatial and temporal constraints of the body and "harness them to human intention." Rather than focus on single discrete biotechnologies and their stories--embryonic stem cells, transgenic animals--Landecker documents and explores the wider genre of technique behind artificial forms of cellular life. She traces the lab culture common to all those stories, asking where it came from and what it means to our understanding of life, technology, and the increasingly blurry boundary between them. The technical culture of cells has transformed the meaning of the term "biological," as life becomes disembodied, distributed widely in space and time. Once we have a more specific grasp on how altering biology changes what it is to be biological, Landecker argues, we may be more prepared to answer the social questions that biotechnology is raising.

Download or read book Rebel Cell written by Kat Arney and published by BenBella Books. This book was released on 2020-10-20 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

Download or read book Conspiracy in Death written by J. D. Robb and published by Penguin. This book was released on 1999-04-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a future where human nature remains as predictable as death, a killer plays God and puts innocent lives in the palm of his hand in this novel in the #1 New York Times bestselling In Death series. With the precision of a surgeon, a serial killer preys on the most vulnerable souls of the world’s city streets. The first victim: a sidewalk sleeper, found dead in New York City. No bruises, no signs of struggle. Just a laser-perfect, fist-sized hole where his heart had once been. Lieutenant Eve Dallas is assigned to investigate. But in the heat of a cat-and-mouse game with the killer, Dallas’s job is suddenly on the line. Now her hands are tied...between a struggle for justice—and a fight for her career...

Download or read book Cell written by Robin Cook and published by Macmillan. This book was released on 2014-01-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: George Wilson, M.D., a radiology resident in Los Angeles, is about to enter a profession on the brink of an enormous paradigm shift, foreshadowing a vastly different role for doctors everywhere. A new smartphone app is being developed that is far more than a mere reference tool, rather it is a fully customizable personal physician capable of diagnosing and treating patients more efficiently than the real thing. It is called iDoc. George's initial collision with this incredible innovation is devastating. He awakens one morning to find his fiancée dead in bed alongside him, not long after she participated in an iDoc beta test. Then several of his patients die after undergoing imaging procedures. All of them had been part of the same beta test. Is it possible that iDoc is being subverted by hackers - and that the US government is involved in a cover-up? Despite threats to both his career and his freedom, George relentlessly seeks the truth, knowing that if he's right, the consequences could be lethal.

Download or read book Mandy Hoffen and a Conspiracy to Resurrect Life and Social Justice in Science Curriculum with Henrietta Lacks written by Dana Compton McCullough and published by IAP. This book was released on 2021-06-01 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a theoretical inquiry into alternative pedagogies that challenge current standardized practices in the field of science education. Through Mandy Hoffen, a fictional persona, Dana McCullough, the author, explores how stories of Henrietta Lacks become part of a conspiracy to change science education. Mandy Hoffen, however, never expected to find herself in the middle of a conspiracy. As a science teacher of 20 plus years, she worked diligently to meet the needs of her charges, who are currently ninth and tenth grade biology students in an age of standardized testing. The author also creates imaginary dialogues which serve as the theoretical framework for each chapter. Each chapter unfolds in a form of a play with imaginary settings and events that bring Henrietta Lacks back from the grave to participate in conversations about science, society, and social justice. The imaginary conversations are based on the author’s experiences in graduate courses, direct quotations from philosophers of science, historians of science, science educators, curriculum theorists, and stories of students in their study of Henrietta Lacks in a high school biology classroom. The play describes the journey of a graduate student/high school teacher as she researches the importance of the philosophy of science, history of science, science curriculum and social justice in science education. Through reflections on fictional conversations, stories of Henrietta Lacks are examined and described in multiple settings, beginning in an imaginary academic meeting, and ending with student conversations in a classroom. Each setting provides a space for conversations wherein participants explore their personal connections with science, science curriculum, issues of social justice related to science, and Henrietta Lacks. This book will be of interest to graduate students, scholars, and undergraduates in curriculum studies, educational foundations, and teacher education, and those interested in alternative research methodologies. This is the first book to intentionally address the stories of Henrietta Lacks and their importance in the field of curriculum studies, science studies, and current standardized high school science curriculum.

Download or read book Medicine s 10 Greatest Discoveries written by Meyer Friedman and published by Yale University Press. This book was released on 1998-01-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1675, Antony van Leeuwenhoek, an unlearned haberdasher from Delft, placed a drop of rainwater under his microscope and detected thousands of tiny animals in it. Leeuwenhoek proceeded to examine the microscopic activity of his spittle, teeth plaque, and feces, and as the result of his findings the field of bacteriology was born. Some two hundred years later, Wilhelm Conrad Roentgen, a professor of theoretical physics at the University of Wurzburg, invited his wife to his laboratory, asked her to place her hand on an unexposed photographic plate, turned on an electric current, and showed this terrified woman a picture of the bones of her hand. And so came the discovery of the X-ray. This absorbing book is the first to describe these and eight other monumental medical discoveries throughout history, bringing to life the scientific pioneers responsible for them and the excitement, frustrations, and jealousies that surrounded the final achievements. Two distinguished physicians, Meyer Friedman and Gerald W. Friedland, have drawn on their many years of experience as well as on that of world-renowned antiquarian book dealers, physician collectors of old and new medical publications, and medical school professors to single out these medical breakthroughs from thousands of candidates, and, in several cases, to provide information never before available. Their engrossing stories of the ten most significant discoveries will be read with enjoyment by anyone fascinated by the mysteries of medicine.

Download or read book Stem Cells From Bench To Bedside 2nd Edition written by Ariff Bongso and published by World Scientific. This book was released on 2010-11-04 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology.This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.

Download or read book Medicines from Animal Cell Culture written by Glyn N. Stacey and published by John Wiley & Sons. This book was released on 2007-06-29 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicines from Animal Cell Culture focuses on the use of animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration and the culture of stem cells. Medicines from Animal Cell Culture: Provides comprehensive descriptions of methods for cell culture and nutrition as well as the technologies for the preservation and characterisation of both the cells and the derived products Describes the preparation of stem cells and others for use in cell-based therapies – an area of burgeoning research Includes experimental examples to indicate expected results Covers regulatory issues from the UK, the EU and the USA and reviews how these are developing around the world Addresses the key issues of standardisation and validation with chapters on GLP and GMP for cell culture processes Delivering insight into the exciting world of biological medicines and directions for further investigation into specific topics, Medicines from Animal Cell Culture is an essential resource for researchers and technicians at all levels using cell culture within the pharmaceutical, biotechnology and biomedical industries. It is of value to laboratory managers in these industries and to all those interested in this topic alike.

Download or read book The Leukemia Lymphoma Cell Line Factsbook written by Hans G. Drexler and published by Academic Press. This book was released on 2000-09-04 with total page 751 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leukemia-Lymphoma Cell Line Factsbook represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references. The full spectrum of malignant cell lines from all hematopoietic cell lineages Sister cell lines and relevant subclones Clinical data: patient, diagnosis, treatment status, and specimen source Authentication of derivation and availability Immunophenotype Cytogenetic karyotype Translocations and fusion genes Receptor gene rearrangements and genetic alterations Cell cultures aspects: establishment, medium, doubling time, growth Cytochemical profile Cytokine production and response to cytokines Proto-oncogene and transcription factor expression/alteration Functional features: differentiation induction, heterotransplantability Special unique features Key references

Download or read book Live Cell Assays written by Christophe Furger and published by John Wiley & Sons. This book was released on 2016-07-14 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell assays include all methods of measurements on living cells. Confined for a long time to research laboratories, these emerging methods have, in recent years, found industrial applications that are increasingly varied and, from now on, regulatory. Based on the recent explosion of knowledge in cell biology, the measurement of living cells represents a new class of industry-oriented research tests, the applications of which continue to multiply (pharmaceuticals, cosmetics, environment, etc.). Cellular tests are now being positioned as new tools at the interface between chemical methods, which are often obsolete and not very informative, and methods using animal models, which are expensive, do not fit with human data and are widely discussed from an ethical perspective. Finally, the development of cell assays is currently being strengthened by their being put into regulatory application, particularly in Europe through the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and cosmetic directives.

Download or read book Science and Christian Ethics written by Paul Scherz and published by Cambridge University Press. This book was released on 2019-05-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing crisis in scientific research characterized by failures to reproduce experimental results, fraud, lack of innovation, and burn-out. In Science and Christian Ethics, Paul Scherz traces these problems to the drive by governments and business to make scientists into competitive entrepreneurs who use their research results to stimulate economic growth. The result is a competitive environment aimed at commodifying the world. In order to confront this problem of character, Scherz examines the alternative Aristotelian and Stoic models of reforming character, found in the works of Alasdair MacIntyre and Michel Foucault. Against many prominent virtue ethicists, he argues that what individual scientists need is a regime of spiritual exercises, such as those found in Stoicism as it was adopted by Christianity, in order to refocus on the good of truth in the face of institutional pressure. His book illuminates pressing issues in research ethics, moral education, and anthropology.

Download or read book Advances in Molecular Pathology 2018 written by and published by Elsevier Health Sciences. This book was released on 2018-10-09 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This inaugural issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. Publishing on an annual basis, the volume will be divided into 7 sections: Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid tumors, and Identity/HLA. Led by Dr. Gregory Tsongalis of Dartmouth University, a team of experienced pathologists from institutions across the country oversee annual topic and expert author selection. Topics discussed in this volume include, but are not limited to: whole genome sequencing in critically ill children, bioinformatics in clinical genomic sequencing, comprehensive monitoring of patients with chronic myeloid leukemia, genetic biomarkers in the biology and clinical workup of chronic lymphocytic leukemia, metagenomics in infectious disease, point of care molecular testing, pharmacogenomics in oncology, clinical uses of panel testing vs. single gene testing, large scale data sharing initiatives in genomic oncology, clinical NGS assays for solid tumors emerging concepts in liquid biopsy the cell line and tissue misidentification problem, and cell line detective work.