Download or read book A Clinician s Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics written by Louise B. Grochow and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1999 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William D. Figg and published by Springer Science & Business Media. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Download or read book Cancer Chemoprevention written by Raymond C. Bergan and published by Springer. This book was released on 2012-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.
Download or read book Methods of Therapeutic Drug Monitoring Including Pharmacogenetics written by Georg Hempel and published by Elsevier. This book was released on 2019-10-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
Download or read book Drug Monitoring and Clinical Chemistry written by Georg Hempel and published by Elsevier. This book was released on 2004-05-15 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Download or read book Clinically Relevant Resistance in Cancer Chemotherapy written by Borje Andersson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.
Download or read book Cancer Clinical Pharmacology written by Jan H. M. Schellens and published by Oxford University Press. This book was released on 2005-05-05 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book considers both the theory and practice of clinical pharmacology where it is relevant to cancer treatment. It covers the basics of clinical pharmacology in oncology and cancer therapeutics, discussing the specific classes of anti-cancer agents in detail. Edited and written by a mix of generalist cancer clinical pharmacologists and sub-specialists within this area, the book allows the reader to develop both general clinical pharmacology skills and specialist knowledge for particular cancer chemotherapy agents.
Download or read book Cancer in Children and Adolescents written by William L. Carroll and published by Jones & Bartlett Publishers. This book was released on 2010-10-22 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last six decades, there has been tremendous improvement in the survival rate for the majority of children affected by cancer in the United States and in Western Europe. Despite dramatic advances in the “developed” world, 85% of children diagnosed with cancer globally will not survive this disease. Cancer in Children and Adolescents is an accessible textbook that covers the complexities and interdisciplinary nature of cancer occurrences and provides the fundamentals of diagnosis and management of cancers that affect children and adolescents. Distinguished for its global focus, many chapters in Cancer in Children and Adolescents are co-authored by recognized specialists from around the world. Cancer in Children and Adolescents is divided into four major sections: Section 1: The Laboratory Biology and Diagnostic Evaluation of Childhood Cancer Section 2: Principles of Cancer Therapy in Children Section 3: Tumors of Children Section 4: Supportive Care
Download or read book Karch s Focus on Nursing Pharmacology written by Rebecca G. Tucker and published by Lippincott Williams & Wilkins. This book was released on 2022-07-05 with total page 2747 pages. Available in PDF, EPUB and Kindle. Book excerpt: Karch’s Focus on Nursing Pharmacology, 9th Edition, makes challenging concepts approachable to help students establish a foundation for effective drug therapy throughout their nursing careers. Concise, clearly written, and streamlined for today’s busy students, this trusted text builds on students’ knowledge of physiology, chemistry, and nursing fundamentals to help them conceptualize need-to-know information. The thoroughly updated 9th Edition emphasizes content essential to students’ success on the NCLEX® and cultivates students’ clinical judgment to ensure a smooth, confident transition to nursing practice.
Download or read book 100 Cases in Obstetrics and Gynaecology Second Edition written by Cecilia Bottomley and published by CRC Press. This book was released on 2014-09-09 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 35-year-old woman arrives on the labour ward complaining of abdominal pain and vaginal bleeding at 36 weeks 2 days' gestation. The pain started 2 hours earlier while she was in a cafe and is not relieved by lying still or walking around. The bleeding is bright red. You are the medic on duty... 100 Cases in Obstetrics and Gynaecology presents 100 obstetric- or gynaecology-related scenarios commonly seen by medical students and junior doctors in the emergency department, outpatient clinic, or on the ward. A succinct summary of the patient's history, examination, and initial investigations—including photographs where relevant—is followed by questions on the diagnosis and management of each case. The answer includes a detailed discussion on each topic, with further illustration where appropriate, providing an essential revision aid as well as a practical guide for students and junior doctors. Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. These true-to-life cases will teach students and junior doctors to recognize important obstetric and gynaecological conditions, and to develop their diagnostic and management skills.
Download or read book Brain and Spinal Tumors of Childhood written by David Walker and published by CRC Press. This book was released on 2004-07-30 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children with brain and spinal tumors account for 20-25% of childhood cancers. Until the early 1990s there had been little progress in the development of new treatments, and outcomes were not improving despite advances seen in other childhood cancers. During the past 10 years, however, there has been a dramatic increase in interest in the subject a
Download or read book Brain and Spinal Tumors of Childhood written by David A. Walker and published by CRC Press. This book was released on 2020-11-22 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.
Download or read book Comprehensive Geriatric Oncology written by Lodovico Balducci and published by CRC Press. This book was released on 2004-03-01 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 2004: This new edition of Comprehensive Geriatric Oncology still offers an exhaustive review of the biology of cancer and aging, of the epidemiologic trends in the country and in the world, and of the clinical trials that concern cancer prevention and cancer treatment in the elderly.
Download or read book Hale s Medications Mothers MilkTM 2019 written by Dr. Thomas W. Hale, PhD and published by Springer Publishing Company. This book was released on 2018-05-28 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Earlier Editions: “[This] is our gold standard.” --Sandra J. Cole, RNC, IBCLC Sharp Mary Birch Hospital, San Diego, CA “I am both a clinical instructor in maternal/child and IBCLC. I haven't used Briggs since Hale came along.” --Barbara Hotelling, MSN WHNP LCCE CD(DONA) CHT IBCLC Duke University Medical Center Written by a world-renowned expert in perinatal pharmacology, this essential reference contains current, complete, and evidence-based information on the transmission of maternal drugs into human milk. Because so many women ingest medications while breastfeeding, one of the most common questions encountered in pediatrics is: Which drugs are safe and which are hazardous for the infant? This 2019 edition has been extensively revised, and now includes 39 completely new and 331 updated medications, and state-of-the-art coverage of multiple diseases, vaccines, and syndromes. It addresses the use of radiopharmaceuticals, chemotherapeutic agents, and vaccines in breastfeeding mothers, and covers adult concerns, methods of reducing risk to infants, and infant monitoring. New to the 2019 Edition: An updated design for easier access to information Drug names in running heads for easier reference The latest information on the impact of prescription medications, over-the-counter drugs, herbs, and street drugs Updates to existing drug monographs Key Features: Evidence-based, current information on over 1300 drugs, diseases, vaccines and syndromes Dr. Hale’s renowned “Lactation Risk Categories” Adult concerns, adult dose, pediatric concerns, infant monitoring, and alternatives Key points and savvy tips about breastfeeding and medications for quick reference Succinct information about evaluation of the infant Common abbreviations and drugs listed in alphabetical order
Download or read book Basic and Clinical Pharmacology written by Bertram G. Katzung and published by . This book was released on 2001 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This best selling book delivers the most current, complete, and authoritative pharmacology information to students and practitioners. All sections are updated with new drug information and references. New! Many new figures and diagrams, along with boxes of highlighted material explaining the "how and why" behind the facts.
