Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Download or read book Clinical Psychopharmacology written by Paul F. Smith and published by Routledge. This book was released on 2013-02-01 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a concise introduction to the physiological, biochemical, and behavioral issues surrounding drug interventions in the treatment of psychological and neurological disorders. It was written for the reader who does not have an extensive background in these subjects but would like an accurate, current, and succinct account of clinical psychopharmacology. Descriptions of the drugs used to treat psychological disorders such as anxiety, depression, and psychosis; and neurological disorders such as chronic pain, epilepsy, and Parkinson's disease constitute the major portions of this book. There is also coverage of drugs of abuse as well as issues specific to the problems of prescribing and monitoring drug treatment in pediatric and geriatric populations. To help avoid the possibility of brand name confusion, pharmacological names for drugs are used. A convenient table matches the generic names with lists of brand names available in the United States. As such, this volume will be a valuable guide for psychology and clinical psychology students as well as nurses and medical students.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Receptor Based Drug Design written by Paul Leff and published by CRC Press. This book was released on 1998-04-10 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process! Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors shows how to assess agonist concentration-effect curve data discusses radioligand binding assays presents new in vitro multiarray assays for G-protein-coupled receptors explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions examines the role of electrophysiology in finding new drugs and drug targets describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment outlines the rationale for using angiotensin receptor antagonists and more! Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

Download or read book Leukotrienes written by Ian Rodger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.

Download or read book Advances in Molecular Toxicology written by Claude Reiss and published by VSP. This book was released on 1998-02 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Download or read book Lipoxygenases and their Metabolites written by Santosh Nigam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).

Download or read book Receptor Ion Channel Nomenclature Supplement written by and published by . This book was released on 1995 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Concise Dictionary of Pharmacological Agents written by I.K. Morton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource. The authors, who have many years experience in pharmacological research, teaching and editing, recognized a need for a single up-to-date volume encompassing material that hitherto could be gathered only from a well-stocked library. This book comprises two main sections: an A-Z listing of drugs and their properties; and a descriptive glossary of technical terms. The level and scope of this reference material will make it essential for pharmacologists and medicinal chemists, from the graduate student to established worker. It should also be valuable to workers in allied biomedical diSCiplines, such as biochemistry and physiology, medical students and science writers and editors. Scope The dictionary is centred on pharmacologically active agents. Workers in drug-related diSCiplines need to correctly identify individual agents from an arsenal of pharmacologically active compounds, each with a number of alternative drug names according to the country or naming convention.

Download or read book Peptidergic G Protein coupled Receptors written by Pierangelo Geppetti and published by IOS Press. This book was released on 1999 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides are a rapidly growing class of mediators whose activity regulates homeostasis as well as pathological processes. Most of the peptide-activated receptors belong to the superfamily of 7 transmembrane domain receptors coupled to G proteins. Peptides of different sizes (from a few to more than 100 aminoacids) activate peptidergic receptors by interacting at specific sites, that often differ from those where antagonists bind. Other receptors are activated by proteases that, by cleaving the receptor extracellular region, unmask a tethered ligand. G protein-coupled receptors for chemokines represent the way of entry of the HIV virus in target cells. The great impact of non peptide agonist/antagonists in current and future medicine reflects these large variety of functions and modes of activation of peptidergic G protein-coupled receptors.

Download or read book Molecular Neuroscience written by Dr P Revest and published by Garland Science. This book was released on 1998-06-15 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to neuroscience, focusing particularly on the rapidly developing molecular aspects. The techniques of molecular biology are introduced and described in the context of their role in elucidating brain function at the molecular level.

Download or read book Biomembrane Transport written by Lon J. Van Winkle and published by Elsevier. This book was released on 1999-05-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomembrane Transport covers the fundamental principles of biomembrane transport proteins, including thermodynamics and kinetics, structure and catalytic mechanism, and regulation and integration classification. The book considers recent advances in transport protein structure and function, along with established concepts. The importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism is covered, as well as classical and modern techniques for characterizing transport. The book also contains a classification scheme for all known transport proteins according to their functions and amino acid residue sequence similarities. - Considers recent advances in transport protein structure and function, along with established concepts - Distinguishes the similarities and differences in the mechanisms of action of transport proteins - Provides an up-to-date discussion of the thermodynamics and kinetics of biomembrane transport - Discusses regulation of biomembrane transport - Details the importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism - Contains a classification scheme for all known transport proteins according to their functions and amino acid residue sequence similarities - Presents classical and modern techniques for characterizing transport

Download or read book Neuropsychiatry written by Randolph B. Schiffer and published by Lippincott Williams & Wilkins. This book was released on 2003 with total page 1302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised Second Edition builds on the success of the first as the definitive text for neuropsychiatry. The book is divided into three sections, with the third on syndromes and disorders. Emphasis on treatment is provided throughout the text and is DSM-IV-compatible. Coverage includes neurobehavioral disorders, selection and interpretation of neurodiagnostic procedures, and the full spectrum of therapies. New to this edition are eight chapters and the incorporation of psychopharmacology into specific disease chapters. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Download or read book Basic Clinical Pharmacology written by Bertram G. Katzung and published by McGraw-Hill/Appleton & Lange. This book was released on 1998 with total page 1176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition contains new material on receptors, including their molecular biology, and updated information on central nervous system drugs, including new drugs released through to July 1996.

Download or read book Molecular Modeling and Prediction of Bioactivity written by Klaus Gundertofte and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane penetration. For any set of compounds, these relationships are by necessity complicated, particularly when the properties are of biological nature. To investigate and utilize such complicated relationships, henceforth abbreviated SAR for structure-activity relationships, and QSAR for quantitative SAR, we need a description of the variation in chemical structure of relevant compounds and biological targets, good measures of the biological properties, and, of course, an ability to synthesize compounds of interest. In addition, we need reasonable ways to construct and express the relationships, i. e. , mathematical or other models, as well as ways to select the compounds to be investigated so that the resulting QSAR indeed is informative and useful for the stated purposes. In the present context, these purposes typically are the conceptual understanding of the SAR, and the ability to propose new compounds with improved property profiles. Here we discuss the two latter parts of the SARlQSAR problem, i. e. , reasonable ways to model the relationships, and how to select compounds to make the models as "good" as possible. The second is often called the problem of statistical experimental design, which in the present context we call statistical molecular design, SMD. 1.

Download or read book Essential Cardiology written by Clive Rosendorff and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading researchers and clinician-scientists distill from years of practical experience and recent scientific and clinical advances the essence of cardiology principles and techniques today. In this second edition, all of the original chapters have been extensively rewritten and two new chapters on acute coronary syndromes following the modern classification have been added: one on unstable angina pectoris and non-ST-segment elevation myocardial infarction, and the other on ST-segment elevation myocardial infarction. Compact yet comprehensive, Essential Cardiology: Principles and Practice, Second Edition offers today's busy cardiology and internal medicine practitioners, cardiology fellows, and medical residents rapid access to the latest ideas and techniques needed for today's gold standard diagnosis and management of cardiac patients.

Download or read book Proceedings Of The 5th Asia pacific Bioinformatics Conference written by Francis Y L Chin and published by World Scientific. This book was released on 2007-01-12 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughput sequencing and functional genomics technologies have given us the human genome sequence as well as those of other experimentally, medically, and agriculturally important species, and have enabled large-scale genotyping and gene expression profiling of human populations. Databases containing large numbers of sequences, polymorphisms, structures, and gene expression profiles of normal and diseased tissues are being rapidly generated for human and model organisms. Bioinformatics is thus rapidly growing in importance in the annotation of genomic sequences; the understanding of the interplay among and between genes and proteins; the analysis of genetic variability of species; the identification of pharmacological targets; and the inference of evolutionary origins, mechanisms, and relationships. This proceedings volume contains an up-to-date exchange of knowledge, ideas, and solutions to conceptual and practical issues of bioinformatics by researchers, professionals, and industrial practitioners at the 5th Asia-Pacific Bioinformatics Conference held in Hong Kong in January 2007./a