Download or read book Potassium Channels And Their Modulators written by John M Evans and published by CRC Press. This book was released on 1996-04-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in th

Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemical Ecology written by for the National Academy of Sciences and published by National Academies Press. This book was released on 1995-09-01 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical signals among organisms form "a vast communicative interplay, fundamental to the fabric of life," in the words of one expert. Chemical ecology is the the discipline that seeks to understand these interactions-to use biology in the search for new substances of potential benefit to humankind. This book highlights selected research areas of medicinal and agricultural importance. Leading experts review the chemistry of: Insect defense and its applications to pest control. Phyletic dominanceâ€"the survival success of insects. Social regulation, with ant societies as a model of multicomponent signaling systems. Eavesdropping, alarm, and deceitâ€"the array of strategies used by insects to find and lure prey. Reproductionâ€"from the gamete attraction to courtship nd sexual selection. The chemistry of intracellular immunosuppression. Topics also include the appropriation of dietary factors for defense and communication; the use of chemical signals in the marine environment; the role of the olfactory system in chemical analysis; and the interaction of polydnaviruses, endoparasites, and the immune system of the host.

Download or read book Clinical Psychopharmacology written by Paul F. Smith and published by Routledge. This book was released on 2013-02-01 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a concise introduction to the physiological, biochemical, and behavioral issues surrounding drug interventions in the treatment of psychological and neurological disorders. It was written for the reader who does not have an extensive background in these subjects but would like an accurate, current, and succinct account of clinical psychopharmacology. Descriptions of the drugs used to treat psychological disorders such as anxiety, depression, and psychosis; and neurological disorders such as chronic pain, epilepsy, and Parkinson's disease constitute the major portions of this book. There is also coverage of drugs of abuse as well as issues specific to the problems of prescribing and monitoring drug treatment in pediatric and geriatric populations. To help avoid the possibility of brand name confusion, pharmacological names for drugs are used. A convenient table matches the generic names with lists of brand names available in the United States. As such, this volume will be a valuable guide for psychology and clinical psychology students as well as nurses and medical students.

Download or read book Antipsychotics written by John G. Csernansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antipsychotic drugs were first discovered in 1953, and not since the late 1970s has the Handbook of Experimental Pharmacology taken up this topic. A new treatment of this topic would be due under any circumstances; however, this is now particularly true, since remarkable progress has been made on several fronts in furthering our understanding of the mechanisms of antipsychotic drug action. First, we have learned that schizophrenia is an illness with particu lar neuroanatomical abnormalities, many of which suggest that the illness is caused by errors in neurodevelopment. These findings have helped to form a context for understanding neurochemical aberrations in the illness and suggest new approaches for pharmacological treatment. Propelled forward by rapid advances in neurochemical anatomy, current pathophysiological hypotheses of schizophrenia and antipsychotic drug action have taken on the appearance of complex electrical circuit diagrams. Second, molecular biology studies have now revealed that there is a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), some of which may become entirely new targets for 3 4 s antipsychotic drug action. Ironically, the development of drugs that are selec tive for these receptors and that can be used to investigate their function lags behind; yet the discovery of these new receptors offers unparalleled opportu nities for developing drugs with improved efficacy and fewer side effects.

Download or read book Handbook of Psychiatric Genetics written by Kenneth Blum and published by CRC Press. This book was released on 1996-10-29 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.

Download or read book Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters written by M. Morad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Download or read book Marihuana and Medicine written by Gabriel G. Nahas and published by Springer Science & Business Media. This book was released on 1999-04-05 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading physicians and scientists from around the world critically examine the pharmacological and molecular basis of the therapeutic properties of marihuana and its active ingredient, THC. They detail the broad array of marihuana's effects on brain function, the immune system, male and female reproductive functions, and cardiac and pulmonary functions, as well as evaluate its clinical applications in psychiatry, glaucoma, pain management, cancer chemotherapy, and AIDS treatment. Their studies indicate that marihuana persistently impairs the brain and reproductive function, and that marihuana smoke is more toxic and damaging to the lung than tobacco smoke. Marihuana and Medicine's reports of the latest findings on the pharmacological and molecular mechanisms of marihuana and of its clinical manifestations will be essential reading for physicians, psychiatrists, pharmacologists, health-care professionals, policy makers, public health officials, and attorneys.

Download or read book Concise Dictionary of Pharmacological Agents written by I.K. Morton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource. The authors, who have many years experience in pharmacological research, teaching and editing, recognized a need for a single up-to-date volume encompassing material that hitherto could be gathered only from a well-stocked library. This book comprises two main sections: an A-Z listing of drugs and their properties; and a descriptive glossary of technical terms. The level and scope of this reference material will make it essential for pharmacologists and medicinal chemists, from the graduate student to established worker. It should also be valuable to workers in allied biomedical diSCiplines, such as biochemistry and physiology, medical students and science writers and editors. Scope The dictionary is centred on pharmacologically active agents. Workers in drug-related diSCiplines need to correctly identify individual agents from an arsenal of pharmacologically active compounds, each with a number of alternative drug names according to the country or naming convention.

Download or read book Smith and Williams Introduction to the Principles of Drug Design and Action Third Edition written by H. John Smith and published by CRC Press. This book was released on 1998-05-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials

Download or read book Neuroscience LabFax written by M. A. Lynch and published by Elsevier. This book was released on 1997-04-25 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of up-to-date methods and data available in neuroscience, addressing issues from the molecular to the cellular and systems level of analysis. This volume includes coverage of electrophysical recording, neuronal cell culture, and preparation of tissues for microscopy or analysis.

Download or read book Leukotrienes written by Ian Rodger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.

Download or read book G Protein Coupled Receptors written by Tiina P. Iismaa and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.

Download or read book Molecular Neuroscience written by Patricia Revest and published by Garland Science. This book was released on 1998 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to neuroscience, focusing particularly on the rapidly developing molecular aspects. The techniques of molecular biology are introduced and described in the context of their role in elucidating brain function at the molecular level.

Download or read book Autonomic Pharmacology written by Kenneth J Broadley and published by CRC Press. This book was released on 2017-12-14 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic involuntary nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form.; This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.

Download or read book Advances in Epinephrine Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Epinephrine Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Metanephrine. The editors have built Advances in Epinephrine Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Metanephrine in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Epinephrine Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.