Download or read book Synthesis and application of configured 18 19F FDGs written by Mathias Elgland and published by Linköping University Electronic Press. This book was released on 2018-02-21 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.

Download or read book One Day at a Time in Al Anon written by Al-Anon Family Group Headquarters, Inc and published by . This book was released on 1989-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcoholism is a family illness, and changed attitudes can aid recovery. This daily readings guide for family and friends of alcoholics provides meditations and reminder, and visualizations that can provide a measure of comfort, serenity, and a sense of achievement.

Download or read book Geological Survey Water supply Paper written by and published by . This book was released on 1970 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hydrometeorological Log of the Central Sierra Snow Laboratory written by and published by . This book was released on 1947 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The American Ephemeris and Nautical Almanac written by United States Naval Observatory. Nautical Almanac Office and published by . This book was released on 1971 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes separately issued Tables to facilitate the reduction of places of the fixed stars, published Washington, 1869.

Download or read book Matthew Understanding the Bible Commentary Series written by Robert H. Mounce and published by Baker Books. This book was released on 2011-08-01 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Understanding the Bible Commentary Series helps readers navigate the strange and sometimes intimidating literary terrain of the Bible. These accessible volumes break down the barriers between the ancient and modern worlds so that the power and meaning of the biblical texts become transparent to contemporary readers. The contributors tackle the task of interpretation using the full range of critical methodologies and practices, yet they do so as people of faith who hold the text in the highest regard. Pastors, teachers, and lay people alike will cherish the truth found in this commentary series.

Download or read book Spooky Cemeteries written by Dinah Williams and published by Bearport Publishing. This book was released on 2008-01-01 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do the dead tell tales? Readers will find out in this scary trip through 11 of the world’s spookiest graveyards. Among the stops: Chestnut Hill Cemetery in Rhode Island. That’s where a little girl named Mercy Brown is buried. In the late 1800s, her family was hit by tuberculosis. First, her mother and sister died. Then Mercy herself became sick and died. In desperation to save his tubercular son, her father—who had become convinced that Mercy was a vampire rising from the grave each night to suck the life blood from her sibling—dug up her body, cut out her heart and burned it, and served the ashes to her brother. Such compelling historical nonfiction will keep readers eagerly turning the pages in this macabre exploration of the world of the dead. Spooky Cemeteries is part of Bearport’s Scary Places series.

Download or read book Flood on Piney River November 18 19 1957 in Vicinity of Spring City Tennessee written by Tennessee Valley Authority. Division of Water Control Planning and published by . This book was released on 1961 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Programme of the Courses of Instruction written by Massachusetts Institute of Technology and published by . This book was released on 1907 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Technique of Controversy written by Boris Basil Bogoslovsky and published by . This book was released on 1928 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Astronomy Explained Upon Sir Isaac Newton s Principles written by James Ferguson and published by . This book was released on 1809 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Current Construction Reports written by and published by . This book was released on 1991 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Catalogue of Ohio Wesleyan University for Delaware Ohio written by Ohio Wesleyan University and published by . This book was released on 1922 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Catalog written by University of Maine at Orono and published by . This book was released on 1909 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Collected Works written by Philip Schaff and published by DigiCat. This book was released on 2022-11-13 with total page 7313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition includes: "History of the Christian Church" is an eight volume account of Christian history written by Philip Schaff. In this great work Schaff covers the history of Christianity from the time of the apostles to the Reformation period. "The Creeds of Christendom, with a History and Critical Notes" is a three volume set in which Schaff is classifying and explaining many different statements of belief and articles of faith throughout the Christian history. He deals with the history of the creeds, starting with the Ecumenical creeds, and moving to Greek and Roman creeds, then Old Catholic Union creeds, and finally to the Evangelical creeds and Modern Protestant creeds.

Download or read book Catalogue written by West Virginia University and published by . This book was released on 1916 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Water Resources Data for California written by and published by . This book was released on 1970 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: