Download or read book Vesicular Particulate Drug Delivery Systems written by Edited By Prof.R.S.R.Murthy. and published by Career Publishing (CA). This book was released on 2009-09-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics Part 1. Vesicular drug delivery systems a. Liposomes b. Niosomes c. Microemulsions d. Multiple emulsions Part 2. Particulate drug delivery systems e. Microparticles in drug delivery f. Nanoparticles g. Resealed Erythrocytes h. Micellar Drug Delivery Systems i Dendrimers

Download or read book Vesicular Drug Delivery Based Strategies written by Singh and published by . This book was released on 2021-07-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.

Download or read book Nanocarriers Drug Delivery System written by Nirmal Shah and published by Springer Nature. This book was released on 2021-01-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.

Download or read book Systems of Nanovesicular Drug Delivery written by Amit Kumar Nayak and published by Elsevier. This book was released on 2022-07-25 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables

Download or read book Engineering Synthetic and Natural Vesicular System for Tumor targeted Drug Delivery written by Sagar Rayamajhi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine provides exciting opportunities to solve modern-world medical problems from disease diagnosis to therapy. From the first approved nanomedicine in 1995 against cancer, Doxil®, to the recent sensation, lipid nanoparticle-based mRNA vaccine against COVID-19, nanomedicine has come a long way to the state of becoming a platform medical technology. Toward this endeavor, this dissertation is focused on lipid-based vesicles systems, synthetic liposomes, and cell-secreted extracellular vesicles (EVs), where we have explored and optimized efficient engineering techniques to achieve tumor-targeted drug delivery and diagnostic capacity. Liposomes are synthetic vesicles with an aqueous core and phospholipid bilayer and EVs are natural vesicles secreted by cells with protein-lipid bilayer and aqueous core carrying cellular information in terms of proteins and nucleic acid (mRNA, miRNA, DNA). These complementary properties when paired make them highly efficient delivery vehicles in a biological environment, an overarching goal of this dissertation. The main objective of this dissertation is to overcome two major challenges in nanoparticulate drug delivery system: 1) how to overcome endosome degradation of nanoparticles and maximize intracellular bioavailability and 2) how to overcome biological barriers for efficient delivery- rapid immune clearance, circulation stability, epithelial barriers, microenvironment barriers, cellular, and intracellular barriers. Toward this aim, we engineered a pH-sensitive liposome with pH-responsive 3[beta]-[N-(N',N'-dimethylaminoethane)-carbamoyl] (DC) moiety to avoid endosomal degradation. pH-sensitive liposome showed pH-responsive cationic properties which elevated the fusogenic characteristic of liposome at the acidic environment in the endosomes and facilitate endosomal escape via membrane fusion (Chapter 3). Although the in-vitro results were promising, the challenge to overcome the biological barrier remains. To overcome this problem, a natural messenger of the cellular system, which has been optimized with years of evolution, EVs, was used. We optimized a simple, efficient, and reproducible EVs isolation method by combining centrifugation, ultrafiltration, and size exclusion-based chromatography. Synthetic liposomes were used to engineer an EVs-based hybrid system that contributed to increasing overall yield, stability, and added functionality (Chapter 4). EVs derived from mouse macrophage J774A.1 showed preferential interaction toward cancer cells, both in vitro and in vivo mouse models showing promises for tumor-targeted drug delivery. Further, a gadolinium incorporated liposome was synthesized and hybridized with EVs to engineer a hybrid system with diagnostic capacity, which showed contrast-enhanced diagnostic characteristics as confirmed by clinical magnetic resonance imaging (Chapter 5). Finally, EVs were optimized for their reproducibility of physicochemical and functional properties. Rigorous EVs isolation technique and characterization confirmed the EVs production is significantly higher in cancer cells compared to non-cancer (Chapter 6). The nanosystems engineered in this study were successful to overcome endosomal degradation via escape, have longer retention time, good biocompatibility, efficient drug loading capacity, and tumor targeting characteristic, all of which are excellent properties for drug delivery systems. With this proof of concept and design consideration, this dissertation adds an important understanding of the vesicles-based system for tumor-targeted drug delivery. We envision that future works on the molecular mechanism behind the achieved biomimicry and tumor targeting potential can lead toward the translation of a vesicle-based system for tumor-targeted drug delivery.

Download or read book Silk based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Download or read book Future Strategies for Drug Delivery with Particulate Systems written by Julia E. Diederichs and published by . This book was released on 1998 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers from a March 1997 workshop highlight the latest trends in using particulate systems for controlled delivery of drugs. Topics include use of liposomes, emulsions, polymeric nanoparticles, solid lipid nanoparticles, nanosuspensions of poorly soluble and bioavailable drugs, and particulate diagnostics. Covers pharmaceutical applications ranging.

Download or read book The Handbook of Particulate Drug Delivery written by Majeti N. V. Ravi Kumar and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Particulate Drug Delivery Applications written by M. N. V. Ravi Kumar and published by . This book was released on 2008 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Delivery Systems Advanced Technologies Potentially Applicable in Personalised Treatment written by Jorge Coelho and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.

Download or read book Nanocosmetics and Nanomedicines written by Ruy Beck and published by Springer Science & Business Media. This book was released on 2011-04-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.

Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Download or read book Drug Carrier Systems written by A. M. Kroon and published by John Wiley & Sons. This book was released on 1989 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the main developments of the past 20 years, relating advances in systems that release the active drug in a sustained and controlled way, and new drugs that address more specifically the tissues and cells with which they are designed to interact. Considers the problems of biodistribution and biodegradation, with in-depth discussion of the selectivity and toxicity of the drugs administered by the various carrier systems. Topics covered range from antibodies, polymers, liposomes, erythrocytes and erythrocyte ghosts, to implantable infusion pumps. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR

Download or read book Strategies to Modify the Drug Release from Pharmaceutical Systems written by Marcos Luciano Bruschi and published by Woodhead Publishing. This book was released on 2015-06-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications

Download or read book Targeted Drug Delivery Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Download or read book Polymeric Drug Delivery Systems written by Glen S. Kwon and published by CRC Press. This book was released on 2005-04-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Download or read book Nanoemulsions written by Seid Mahdi Jafari and published by Academic Press. This book was released on 2018-02-24 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods