Download or read book La m thode de calcul des Limites R siduelles Acceptables un pilier de l optimisation de la strat gie de la validation de nettoyage dans l industrie pharmaceutique written by Fanny Dupuy and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dans l'industrie pharmaceutique, le nettoyage représente un pilier fondamental dans la lutte contre les contaminations des produits fabriqués. Afin d'évaluer l'efficacité de cette opération la stratégie de validation de nettoyage est particulièrement importante. Cela passe notamment par le choix de seuils d'acceptation adaptés et pertinents (prise en compte de la Permitted Daily Exposure (PDE), de la surface réelle des équipements...). Ce travail expose donc dans un premier temps, les différents modes de contamination et les différents moyens mis en œuvre pour les éviter. Puis, il détaille les pré requis à la validation de nettoyage ainsi que ses diverses étapes. Pour finir, il présente un exemple concret d'optimisation de stratégie de validation de nettoyage via le calcul de nouvelles Limites Résiduelles Acceptables (LRA) et le choix de nouveaux critères d'acceptation.
Download or read book Faecal Sludge Management written by Linda Strande and published by IWA Publishing. This book was released on 2014-08-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is estimated that literally billions of residents in urban and peri-urban areas of Africa, Asia, and Latin America are served by onsite sanitation systems (e.g. various types of latrines and septic tanks). Until recently, the management of faecal sludge from these onsite systems has been grossly neglected, partially as a result of them being considered temporary solutions until sewer-based systems could be implemented. However, the perception of onsite or decentralized sanitation technologies for urban areas is gradually changing, and is increasingly being considered as long-term, sustainable options in urban areas, especially in low- and middle-income countries that lack sewer infrastructures. This is the first book dedicated to faecal sludge management. It compiles the current state of knowledge of the rapidly evolving field of faecal sludge management, and presents an integrated approach that includes technology, management, and planning based on Sandecs 20 years of experience in the field. Faecal Sludge Management: Systems Approach for Implementation and Operation addresses the organization of the entire faecal sludge management service chain, from the collection and transport of sludge, and the current state of knowledge of treatment options, to the final end use or disposal of treated sludge. The book also presents important factors to consider when evaluating and upscaling new treatment technology options. The book is designed for undergraduate and graduate students, and engineers and practitioners in the field who have some basic knowledge of environmental and/or wastewater engineering.
Download or read book Some Antiviral and Antineoplastic Drugs and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.
Download or read book Analysis of Food Constituents written by J.-L. Multon and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ob Analyse eines Nahrungsmittelbestandteils, Interpretation von Meßwerten oder Risikoabschätzung - dieses vierbändige Nachschlagewerk für die Praxis, dessen letzter Band jetzt vorliegt, läßt keine wichtige Frage offen. Mit umfassender Bibliographie.
Download or read book Pharmaceutical Isolators written by Brian Midcalf and published by Pharmaceutical Press. This book was released on 2004 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work considers the basic concepts, definitions, and standards necessary in the design, construction, commissioning, maintenance, and use of pharmaceutical isolators.
Download or read book An Outline for Work in Experimental Engineering in the Engineering Department of the University of Virginia written by Jared Stout Lapham and published by . This book was released on 1919 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Functional Art written by Alberto Cairo and published by New Riders. This book was released on 2012-08-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike any time before in our lives, we have access to vast amounts of free information. With the right tools, we can start to make sense of all this data to see patterns and trends that would otherwise be invisible to us. By transforming numbers into graphical shapes, we allow readers to understand the stories those numbers hide. In this practical introduction to understanding and using information graphics, you’ll learn how to use data visualizations as tools to see beyond lists of numbers and variables and achieve new insights into the complex world around us. Regardless of the kind of data you’re working with–business, science, politics, sports, or even your own personal finances–this book will show you how to use statistical charts, maps, and explanation diagrams to spot the stories in the data and learn new things from it. You’ll also get to peek into the creative process of some of the world’s most talented designers and visual journalists, including Condé Nast Traveler’s John Grimwade , National Geographic Magazine’s Fernando Baptista, The New York Times’ Steve Duenes, The Washington Post’s Hannah Fairfield, Hans Rosling of the Gapminder Foundation, Stanford’s Geoff McGhee, and European superstars Moritz Stefaner, Jan Willem Tulp, Stefanie Posavec, and Gregor Aisch. The book also includes a DVD-ROM containing over 90 minutes of video lessons that expand on core concepts explained within the book and includes even more inspirational information graphics from the world’s leading designers. The first book to offer a broad, hands-on introduction to information graphics and visualization, The Functional Art reveals: • Why data visualization should be thought of as “functional art” rather than fine art • How to use color, type, and other graphic tools to make your information graphics more effective, not just better looking • The science of how our brains perceive and remember information ¿ • Best practices for creating interactive information graphics • A comprehensive look at the creative process behind successful information graphics ¿ • An extensive gallery of inspirational work from the world’s top designers and visual artists On the DVD-ROM: In this introductory video course on information graphics, Alberto Cairo goes into greater detail with even more visual examples of how to create effective information graphics that function as practical tools for aiding perception. You’ll learn how to: incorporate basic design principles in your visualizations, create simple interfaces for interactive graphics, and choose the appropriate type of graphic forms for your data. Cairo also deconstructs successful information graphics from The New York Times and National Geographic magazine with sketches and images not shown in the book. All of Peachpit's eBooks contain the same content as the print edition. You will find a link in the last few pages of your eBook that directs you to the media files. Helpful tips: If you are able to search the book, search for "Where are the lesson files?" Go to the very last page of the book and scroll backwards. You will need a web-enabled device or computer in order to access the media files that accompany this ebook. Entering the URL supplied into a computer with web access will allow you to get to the files. Depending on your device, it is possible that your display settings will cut off part of the URL. To make sure this is not the case, try reducing your font size and turning your device to a landscape view. This should cause the full URL to appear.
Download or read book Global Burden of Disease and Risk Factors written by Alan D. Lopez and published by World Bank Publications. This book was released on 2006-04-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Download or read book Biotechnology and Sustainable Development written by Ismail Serageldin and published by CABI. This book was released on 2003 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the first scientific conference convened at the Library of Alexandria, 'Biotechnology and Sustainable Development: Voices of the South and North', which was held in Alexandria, Egypt, in March 2002, this book contains overviews of agriculture, health, ethics and the environment. It discusses how dramatic improvements in food security, health, and lifestyle could accrue to the poor people of developing countries through the applications of new technologies.
Download or read book Cleaning Validation written by Destin A. LeBlanc and published by CRC Press. This book was released on 2022-12-23 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical manufacturers and upper management are encouraged to meet the challenges of the science-based and risk-based approaches to cleaning validation. Using some of the principles and practices in this volume will help in designing a more effective and efficient cleaning validation program. Features • Timely coverage of cleaning validation for the pharmaceutical industry, a dynamic area in terms of health-based limits. • The author encourages pharmaceutical manufacturers, and particularly upper management, to meet the challenges of the science-based and riskbased approaches to cleaning validation. • Draws on the author’s vast experience in the field of cleaning validation and hazardous materials. • Discusses EMA vs. ISPE on Cleaning Limits and revised Risk-MaPP for highly hazardous products in shared facilities. • A diverse list of topics from protocol limits for yeasts and molds to cleaning validation for homeopathic drug products.
Download or read book Jean Baptiste Say and Political Economy written by Jean-Baptiste Say and published by Taylor & Francis. This book was released on 2016-11-10 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jean-Baptiste Say (1767–1832) was one of the first great economists to have laid down the foundations of economic science. Author of the famous Treatise on Political Economy in 1803, which was revised and re-edited on several occasions, he published numerous other works including a voluminous Complete Course in Practical Political Economy in 1828–9. He also taught political economy successively from 1815 until his death in three Parisian establishments: the Athénée, the Conservatory of Arts and Trades, and the Collège de France. The texts in which Say exposes his approach to political economy have not been available in the English language until now except for the fourth edition of the ‘Preliminary Discourse’ which serves as an introduction to the Treatise. This book presents a translation which renders his works accessible to the English speaking world. For the first time, English readers will be able to become directly immersed in Say’s principal texts, where he develops his conception of political economy. Jean-Baptiste Say and Political Economy proposes a translation of a selection of eleven of Say’s texts. The first three are versions of the ‘Preliminary Discourse’ from the Treatise’s editions of 1803, 1814 and 1826 with the variations of the editions of 1817, 1819 and 1841. The following four texts are the opening discourses pronounced at the Conservatory in 1820 and 1828 and the Collège de France in 1831 and 1832. The eighth text is the ‘General Considerations’ which open the Complete Course in Practical Political Economy of 1828, with the variations of the 1840 re-edition. The final three texts are those Say devotes to ‘the progress of political economy’ in what is akin to a history of economic thought. This volume is of great importance to economic historians and people studying Jean-Baptiste Say, as well as those who are interested in economic theory and philosophy and political economy.
Download or read book Cambridge Handbook of Engineering Education Research written by Aditya Johri and published by Cambridge University Press. This book was released on 2014-02-10 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cambridge Handbook of Engineering Education Research is the critical reference source for the growing field of engineering education research, featuring the work of world luminaries writing to define and inform this emerging field. The Handbook draws extensively on contemporary research in the learning sciences, examining how technology affects learners and learning environments, and the role of social context in learning. Since a landmark issue of the Journal of Engineering Education (2005), in which senior scholars argued for a stronger theoretical and empirically driven agenda, engineering education has quickly emerged as a research-driven field increasing in both theoretical and empirical work drawing on many social science disciplines, disciplinary engineering knowledge, and computing. The Handbook is based on the research agenda from a series of interdisciplinary colloquia funded by the US National Science Foundation and published in the Journal of Engineering Education in October 2006.
Download or read book Engineering written by Unesco and published by UNESCO. This book was released on 2010-01-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report reviews engineering's importance to human, economic, social and cultural development and in addressing the UN Millennium Development Goals. Engineering tends to be viewed as a national issue, but engineering knowledge, companies, conferences and journals, all demonstrate that it is as international as science. The report reviews the role of engineering in development, and covers issues including poverty reduction, sustainable development, climate change mitigation and adaptation. It presents the various fields of engineering around the world and is intended to identify issues and challenges facing engineering, promote better understanding of engineering and its role, and highlight ways of making engineering more attractive to young people, especially women.--Publisher's description.
Download or read book Cleaning Validation Manual written by Syed Imtiaz Haider and published by CRC Press. This book was released on 2010-05-24 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, enormous progress and enhancement of pharmaceutical manufacturing equipment and its use have been made. And while there are support documents, books, articles, and online resources available on the principles of cleaning and associated processing techniques, none of them provides a single database with convenient, ready-to-
Download or read book William Trevor written by Suzanne Morrow Paulson and published by . This book was released on 1993 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Intensely poetic, understated, and ironic, William Trevor's fiction contains the very hallmarks of the modern short story, following a long tradition of Irish and British literature about the often painful and grueling route people travel in the simple effort to integrate themselves into society. In his many poignant stories - among them "Mulvihill's Memorial," "The Mark-2 Wife," "The Day We Got Drunk on Cake," "Lovers of Their Time," and "The Ballroom of Romance" - Trevor reveals his mastery of tragi-comedy, whereby human interaction at even the most parochial level lends to an understanding of the universal." "In this first book-length study of Trevor's stories, Suzanne Morrow Paulson provides a comprehensive overview of this Anglo-Irish writer's craft, examining his "masterpieces" of the form, his proficiency with the comic as well as the tragic. Trevor writes a personal sort of fiction, Paulson observes, rendering the grotesque aspects of human nature under stress, yet he transcends the personal because his art encourages sympathy for even the most ridiculous figures. Refuting critics who find his work dour and pessimistic, Paulson finds that most of Trevor's stories convey a genuine optimism and a love of people - a love based on a profound understanding of suffering, a sympathetic acceptance of human weakness, and shrewd insights into social hierarchies." "Paulson finds Trevor at his best in stories that express his sympathy for women, sensitive men, and adolescents who suffer from destructive stereotypes of feminine and masculine behavior. Paulson assigns the fiction discussed to four thematic groups: stories that explore the psychology of coping or failing to cope with trauma; stories about fathers and mothers who cannot understand themselves or their adolescent children; stories depicting the suffering of adolescent girls, spinsters, wives, and mothers as they conform to destructive stereotypes governing proper female behavior; and stories concerned with materialistic values promoted by advertising and the mass media." "In Parts 2 and 3 of this clear, concise introduction to the Trevor short-fiction canon Paulson has compiled, first, Trevor's comments on his art, his reader, and his community (including an original 1989 interview with the author), and, second, a survey of responses to Trevor's work and a brief gathering of articles and reviews published in Ireland, England, France, Canada, and America."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Download or read book Eat Sleep Bagpipes Repeat written by Mirako Press and published by Createspace Independent Publishing Platform. This book was released on 2018-07-18 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This adorable music notebook is perfect for staffs, kids and musicians. The high-quality manuscript book includes 110 pages of 12 staves. Let exercise your composing skills with this well-designed music sketchbook! Enjoy!
Download or read book Compendium of Sanitation Systems and Technologies written by Elizabeth Tilley and published by . This book was released on 2014 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
