Download or read book Validation du nettoyage en place d une ligne de prodution d anticorps recombinants par des cellules CHO written by Sophie Pothier and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: La production de médicaments biologiques est en plein essor et permet de développer des thérapies innovantes contre de multiples pathologies, mais elle est complexe et hétérogène, et nécessite des contrôles de la qualité adaptés. Dans ce contexte, la validation du nettoyage est un point critique de la production pharmaceutique. Mon travail s'est focalisé sur la validation du nettoyage en place appliquée à une ligne de production de cellules animales CHO productrices d'anticorps recombinants et à la ligne de purification de ces anticorps. La première partie traite de la production à l'échelle industrielle d'anticorps recombinants par des cellules CHO, et de la particularité de ce type de procédé. La seconde partie présente le nettoyage en place de ces lignes de production, dont la mise en place implique la connaissance des contaminants à éliminer, la prise en compte du design et des matériaux des surfaces à nettoyer et l'utilisation de paramètres et d'agents de nettoyage adaptés. La dernière partie se focalise sur la validation du nettoyage en place et sur la définition de la stratégie de validation. Cette stratégie est basée sur une évaluation des contaminants, des équipements et des produits. Elle permet de déterminer le risque associé à chacun de ces facteurs et de définir le planning des essais, les paramètres à suivre, les méthodes d'analyses et les critères d'acceptation nécessaires.

Download or read book Scientific Canadian Mechanics Magazine and Patent Office Record written by Canada. Patent Office and published by . This book was released on 1966-03 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Confronting Poverty in Iraq written by World Bank and published by World Bank Publications. This book was released on 2011-01-10 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides the most comprehensive and rigorous analysis of Iraqi income and expenditure in several decades. The report makes extensive use of the Iraq Household Socio-Economic Survey, the first nationwide income and expenditure survey since 1988. IHSES data is complemented income and expenditure data from a wide range of other measures of living standards, allowing us to analyze living standards in a holistic way. The analysis presented here was performed with two main goals first, to inform the Government s Poverty Reduction Strategy; and second, to serve as a baseline for future assessments of changes in living standards and the identification of critical issues for deeper examination. Iraqi living standards have two unusual characteristics. First, they have fallen over the past generation. Second, they feature surprisingly little inequality. These characteristics are both rooted in Iraq s recent history of authoritarian government, war, military occupation, insurgency, and civil strife leading to infrastructure destruction and population displacement. There have been few opportunities for individuals to prosper from professional or entrepreneurial activities. Decades of neglected investment have resulted in deterioration of social services and economic infrastructure. Consequently, individuals have lacked capabilities to prosper and an investment climate conducive to prosperity. School enrollment and life expectancy have declined. Extremely low returns to education reflect the combination of poor educational quality and lack of employment opportunities. In terms of economic infrastructure, access to reliable electricity and water, and even access to paved roads are low, are further reflections of decades of neglect. While the upper end of the distribution has been pulled down by a lack of opportunities, the lower end has been supported by direct government provision of food. The Public Distribution System (PDS) provides 85 percent of food needs. While PDS has been useful as a safety net for the poor and the vulnerable, the system is expensive, inefficient, and fiscally risky. Indeed, PDS food rations account for a far greater share of public spending than does education or health. Going forward, Iraq faces two main challenges. First, although Iraq does not have to develop from scratch, it faces a formidable challenge in re-development. Second, a shift by the Government is required from direct provision of basic subsistence toward investment in human capacities. The Government can provide an enabling environment through investments in economic infrastructure and services to business and citizens, thus allowing the population to make productive use of education and their own labor. Both challenges are now being taken up by the Poverty Reduction Strategy, which articulates a detailed set of required actions and outlines priorities for government spending.

Download or read book Conceptual Modeling for Traditional and Spatio Temporal Applications written by Christine Parent and published by Springer Science & Business Media. This book was released on 2006-09-02 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: From environmental management to land planning and geo-marketing, the number of application domains that may greatly benefit from using data enriched with spatio-temporal features is expanding very rapidly. This book shows that a conceptual design approach for spatio-temporal databases is both feasible and easy to apprehend. While providing a firm basis through extensive discussion of traditional data modeling concepts, the major focus of the book is on modeling spatial and temporal information.

Download or read book American Fertilizers written by Perry Eugene Howard and published by . This book was released on 1932 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this publication is given a brief description of the production of commercial fertilizer. It is believed that this description, which complex technical discussion and statistics are avoided, will be of use to students, as well as farmers and gardeners.