Download or read book Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products written by M.M.W.B. Hendriks and published by Elsevier. This book was released on 1996-12-11 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: • Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry • Illustrates the different approaches available to attain robustness • Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.
Download or read book Capillary Electrophoresis Methods for Pharmaceutical Analysis written by Satinder Ahuja and published by Elsevier. This book was released on 2011-08-09 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control. - Provides current status and future developments in CE analysis of pharmaceuticals. - Explains how to develop and validate methods. - Includes major pharmaceutical applications including assays and impurity testing.
Download or read book Validation in Chemical Measurement written by Paul De Bièvre and published by Springer Science & Business Media. This book was released on 2005-01-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The validation of analytical methods is based on the characterisation of a measurement procedure (selectivity, sensitivity, repeatability, reproducibility). This volume collects 31 outstanding papers on the topic, mostly published in the period 2000-2003 in the journal "Accreditation and Quality Assurance". They provide the latest understanding, and possibly the rationale why it is important to integrate the concept of validation into the standard procedures of every analytical laboratory. In addition, this anthology considers the benefits to both: the analytical laboratory and the user of the measurement results.
Download or read book Labostat Guide de validation des m thodes d analyse written by FEINBERG and published by Lavoisier. This book was released on 2012-02-01 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique en son genre dans sa conception et dans son contenu, Labo-Stat - Guide de validation des méthodes d'analyses présente une nouvelle stratégie de validation selon une démarche raisonnée fondée sur le profil d'exactitude. Les techniques statistiques adaptées y sont explicitées sous une forme didactique et les solutions possibles ainsi que les limites éventuelles de diverses normes existantes sont largement développées et illustrées d'exemples concrets directement exploitables. Les applications numériques, sous forme de feuilles de calcul modèles pour des tableurs et des petits scripts, sont téléchargeables en ligne. Complétée par les explications de cet ouvrage, elles permettent au non-statisticien d'accéder aisément à une interprétration graphique des résultats. Labo-Stat a été conçu pour pouvoir être facilement utilisé sur la paillasse du laboratoire et permettre à tout un chacun, responsable, ingénieur, chercheur, technicien ou étudiant, de s'approprier les techniques indispensables pour déboucher sur une conclusion claire et sans ambiguïté et mener la validation des méthodes dans un souci de contrôle des coûts.
Download or read book Handbook of Chemometrics and Qualimetrics written by and published by Elsevier. This book was released on 1997-12-12 with total page 887 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Chemometrics and Qualimetrics
Download or read book Electrokinetic Chromatography written by Ute Pyell and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a thorough theoretical description of the method, an overview on the current status of the various forms of electrokinetic capillary chromatography, plus a look forward into future developments. Focuses on the technique of electrokinetic capillary chromatography and its applications in various areas, including pharmaceutical, industrial, environmental, and biological chemistry Features invaluable information put together from experienced researchers in the area First book to discuss this technique in detail Covers a topic that is part of the exploding field of hyphenated techniques Selected international contributors working in research in this area
Download or read book Analusis written by and published by . This book was released on 1993 with total page 1098 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Verification Validation and Testing of Engineered Systems written by Avner Engel and published by John Wiley & Sons. This book was released on 2010-11-19 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems' Verification Validation and Testing (VVT) are carried out throughout systems' lifetimes. Notably, quality-cost expended on performing VVT activities and correcting system defects consumes about half of the overall engineering cost. Verification, Validation and Testing of Engineered Systems provides a comprehensive compendium of VVT activities and corresponding VVT methods for implementation throughout the entire lifecycle of an engineered system. In addition, the book strives to alleviate the fundamental testing conundrum, namely: What should be tested? How should one test? When should one test? And, when should one stop testing? In other words, how should one select a VVT strategy and how it be optimized? The book is organized in three parts: The first part provides introductory material about systems and VVT concepts. This part presents a comprehensive explanation of the role of VVT in the process of engineered systems (Chapter-1). The second part describes 40 systems' development VVT activities (Chapter-2) and 27 systems' post-development activities (Chapter-3). Corresponding to these activities, this part also describes 17 non-testing systems' VVT methods (Chapter-4) and 33 testing systems' methods (Chapter-5). The third part of the book describes ways to model systems' quality cost, time and risk (Chapter-6), as well as ways to acquire quality data and optimize the VVT strategy in the face of funding, time and other resource limitations as well as different business objectives (Chapter-7). Finally, this part describes the methodology used to validate the quality model along with a case study describing a system's quality improvements (Chapter-8). Fundamentally, this book is written with two categories of audience in mind. The first category is composed of VVT practitioners, including Systems, Test, Production and Maintenance engineers as well as first and second line managers. The second category is composed of students and faculties of Systems, Electrical, Aerospace, Mechanical and Industrial Engineering schools. This book may be fully covered in two to three graduate level semesters; although parts of the book may be covered in one semester. University instructors will most likely use the book to provide engineering students with knowledge about VVT, as well as to give students an introduction to formal modeling and optimization of VVT strategy.
Download or read book Lexique analytique de l anatomie humaine Analytical Lexicon of Human Anatomy Inuktitut Fran ais English written by E. Nieuwborg and published by Peeters Publishers. This book was released on 1993 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Peeters 1993)
Download or read book Gas Chromatography written by Colin Poole and published by Elsevier. This book was released on 2012-07-26 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides comprehensive coverage of modern gas chromatography including theory, instrumentation, columns, and applications addressing the needs of advanced students and professional scientists in industry and government laboratories. Chapters are written by recognized experts on each topic. Each chapter offers a complete picture with respect to its topic so researchers can move straight to the information they need without reading through a lot of background information. Individual chapters written by recognized experts The big picture of gas chromatography from theory, to methods, to selected applications Provides references to other sources in associated areas of study to facilitate research Gives access to core data for practical work, comparison of results and decision making
Download or read book Handbook of Nuclear Engineering written by Dan Gabriel Cacuci and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 3701 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an authoritative compilation of information regarding methods and data used in all phases of nuclear engineering. Addressing nuclear engineers and scientists at all levels, this book provides a condensed reference on nuclear engineering since 1958.
Download or read book Experimentation Validation and Uncertainty Analysis for Engineers written by Hugh W. Coleman and published by John Wiley & Sons. This book was released on 2018-05-08 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helps engineers and scientists assess and manage uncertainty at all stages of experimentation and validation of simulations Fully updated from its previous edition, Experimentation, Validation, and Uncertainty Analysis for Engineers, Fourth Edition includes expanded coverage and new examples of applying the Monte Carlo Method (MCM) in performing uncertainty analyses. Presenting the current, internationally accepted methodology from ISO, ANSI, and ASME standards for propagating uncertainties using both the MCM and the Taylor Series Method (TSM), it provides a logical approach to experimentation and validation through the application of uncertainty analysis in the planning, design, construction, debugging, execution, data analysis, and reporting phases of experimental and validation programs. It also illustrates how to use a spreadsheet approach to apply the MCM and the TSM, based on the authors’ experience in applying uncertainty analysis in complex, large-scale testing of real engineering systems. Experimentation, Validation, and Uncertainty Analysis for Engineers, Fourth Edition includes examples throughout, contains end of chapter problems, and is accompanied by the authors’ website www.uncertainty-analysis.com. Guides readers through all aspects of experimentation, validation, and uncertainty analysis Emphasizes the use of the Monte Carlo Method in performing uncertainty analysis Includes complete new examples throughout Features workable problems at the end of chapters Experimentation, Validation, and Uncertainty Analysis for Engineers, Fourth Edition is an ideal text and guide for researchers, engineers, and graduate and senior undergraduate students in engineering and science disciplines. Knowledge of the material in this Fourth Edition is a must for those involved in executing or managing experimental programs or validating models and simulations.
Download or read book Ciguatera written by Dominique Laurent and published by IRD Editions. This book was released on 2005 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book System Validation and Verification written by Jeffrey O. Grady and published by CRC Press. This book was released on 1997-11-25 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, the terms validation and verification have been very loosely defined in the system engineering world, with predictable confusion. Few hardware or software testing texts even touch upon validation and verification, despite the fact that, properly employed, these test tools offer system and test engineers powerful techniques for identifying and solving problems early in the design process. Together, validation and verification encompass testing, analysis, demonstration, and examination methods used to determine whether a proposed design will satisfy system requirements. System Validation and Verification clear definitions of the terms and detailed information on using these fundamental tools for problem solving. It smoothes the transition between requirements and design by providing methods for evaluating the ability of a given approach to satisfy demanding technical requirements. With this book, system and test engineers and project managers gain confidence in their designs and lessen the likelihood of serious problems cropping up late in the program. In addition to explanations of the theories behind the concepts, the book includes practical methods for each step of the process, examples from the author's considerable experience, and illustrations and tables to support the ideas. Although not primarily a textbook, System Validation and Verification is based in part on validation and verification courses taught by the author and is an excellent supplemental reference for engineering students. In addition to its usefulness to system engineers, the book will be valuable to a wider audience including manufacturing, design, software , and risk management project engineers - anyone involved in large systems design projects.
Download or read book Validation in Thermal Analysis written by Markus Schubnell and published by . This book was released on 2008 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alternative Validation Strategies written by S. Morton McPhail and published by John Wiley & Sons. This book was released on 2007-03-15 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative Validation Strategies is a groundbreaking compendium of the most current research and practical guidelines for time- and cost-saving alternatives to the traditional test validation strategies associated with selection processes. The “state of the science” strategies outlined in this valuable resource will help employers to evaluate the inferences drawn from their selection procedures while offering practices that meet stringent legal and regulatory requirements.
