Download or read book UVAR Beam Port Optimization for Boron Neutron Capture Therapy written by Scott Wimberly Brown and published by . This book was released on 1978 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book OPTIMIZATION OF THE EPITHERMAL NEUTRON BEAM FOR BORON NEUTRON CAPTURE THERAPY AT THE BROOKHAVEN MEDICAL RESEARCH REACTOR written by and published by . This book was released on 2002 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumor had been carried out for half a decade, using an epithermal neutron beam at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 cut short the efforts to implement a new conceptual design to optimize this beam in preparation for use with possible new protocols. Details of the conceptual design to produce a higher intensity, more forward-directed neutron beam with less contamination from gamma rays, fast and thermal neutrons are presented here for their potential applicability to other reactor facilities. Monte Carlo calculations were used to predict the flux and absorbed dose produced by the proposed design. The results were benchmarked by the dose rate and flux measurements taken at the facility then in use.

Download or read book Neutron Beam Design Development and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.

Download or read book Optimization of an Epi thermal Neutron Beam and Beam Dosimetry for Boron Neutron Capture Therapy at the Georgia Tech Research Reactor written by Kathleen A. Klee and published by . This book was released on 1994 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimization Study for an Epithermal Neutron Beam for Boron Neutroncapture Therapy at the University of Virginia Research Reactor written by Thomas Dean Burns and published by . This book was released on 1995 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Determination and Production of an Optimal Neutron Energy Spectrum for Boron Neutron Capture Therapy written by Darren Leo Bleuel and published by . This book was released on 2003 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment written by Narayan S. Hosmane and published by World Scientific. This book was released on 2012 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs have turned the area to be the hottest one and worthy of further investigation with the new clinical trials in the USA and elsewhere.

Download or read book Optimisation of an Epithermal Beam in HIFAR for Boron Neutron capture Therapy written by B. V. Harrington and published by . This book was released on 1987 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimal Neutron Source Beam Shaping Assembly for Boron Neutron Capture Therapy written by and published by . This book was released on 2003 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.

Download or read book Spectral Tailoring for Boron Neutron Capture Therapy written by Victor Alexander Nievaart and published by IOS Press. This book was released on 2007 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first clinical trials on Boron Neutron Capture Therapy in the 1950s, BNCT research has been mainly focussed on the treatment of (deep-seated) brain tumours, in particular, glioblastoma multiforme. Promising work to treat other cancers at other locations and even other diseases are in progress. Therefore, the chemists, medical doctors, physicists and biologists involved in BNCT are not only continuing to investigate and improve the (brain) clinical results, but are also investigating the new applications in BNCT. The work presented in this thesis is in the field of physics and deals, from three different viewpoints, with obtaining the optimal source neutron energy to optimise BNCT. The optimal source neutron energy is defined such as to obtain as many as possible (n, a)-absorptions due to 10B in the tumours and as low as possible total neutron dose in the healthy tissues and organs at risk

Download or read book Optimization of a Moderator Assembly for Use in an Accelerator based Neutron Source for Boron Neutron Capture Therapy written by Jeffrey E. Woollard and published by . This book was released on 1997 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimized Accelerator Based Epithermal Neutron Beams for Boron Neutron Capture Therapy written by Rajat Kudchadker and published by . This book was released on 1996 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron Neutron capture therapy (BNCT) is a form of radiation therapy in which nuclides having a high tendency for capturing thermal neutrons, react by emitting charged particles of short range and leaving essentially no residual radioactivity. If these capture nuclides are selectively introduced into the tumor cells, it is theoretically possible to destroy only the tumor and in the process spare the neighboring healthy tissue. Currently, reactors are the only known source of neutrons being used for BNCT. A number of studies have been done using Monte Carlo computer codes such as MCNP to determine an optimum design of a moderator reflector configuration for an accelerator based neutron source utilizing the Li-7(p, n)Be-7 reaction. To confirm this, benchmark experiments were conducted using both a 2.0 MeV Radio Frequency Quadrupole (RFQ) accelerator and a 2.0 MeV Van de Graaff generator. All previous studies had concluded that 2.5 MeV protons would be optimum, which produces neutron having a maximum energy of 787 keV. For BNCT the desired neutron energies are between 1 eV and nominally 10 keV, i.e. in the epithermal region. These neutrons must hence be moderated to bring them down to the desired energy range. The moderator-reflector assemblies for reactor neutrons or those from 2.5 MeV protons on lithium require a little less than a meter of material to achieve the desired neutron spectrum. This research work focuses on using protons with energies just above the Li-7(p, n)Be-7 reaction threshold. These lower energy protons produce neutrons with a maximum energy of just a few hundred keV requiring much less moderation as compared to the 2.5 MeV proton lithium source. The penalty for the low energy neutron spectrum is the low yield of neutrons per proton as compared to the 2.5 MeV protons on lithium. But, less moderation implies that the patient can be moved closer to the lithium target (neutron source), thus making a more efficient use of the source neutrons. This would partially or wholly compensate for the lower yield per proton. In addition the smaller moderator-reflector assembly would result in less scattering occurring, thereby not degrading the forward directional quality of the beam as much as in current assemblies designed for use with the 2.5 MeV protons on a lithium target.

Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.

Download or read book Optimization of an Accelerator based Epithermal Neutron Source for Neutron Capture Therapy written by and published by . This book was released on 2004 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modeling investigation was performed to choose moderator material and size for creating optimal epithermal neutron beams for BNCT based on a proton accelerator and the 7Li(p, n)7Be reaction as a neutrons source. An optimal configuration is suggested for the beam shaping assembly made from polytetrafluoroethylene and magnesium fluorine. Results of calculation were experimentally tested and are in good agreement with measurements.

Download or read book Boron Neutron Capture Therapy Treatment Planning Improvements written by John Timothy Goorley and published by . This book was released on 1998 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: