Download or read book Medicine and Technology in Canada 1900 1950 written by Allison Kirk-Montgomery and published by . This book was released on 2008 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the past two centuries, technology has played a significant role in the understanding, diagnosis, and treatment of disease in Canada. Technology -- in the form of instruments, devices, machines, drugs, and systems -- has aided medical science, altered medical practice, and changed the illness experience of patients. Nineteenth-century medical technology consisted of predominantly surgical and diagnostic instruments used by individual practitioners. By the twentieth century, large, hospital–based technologies operated by teams emerged as powerful tools in the identification and management of disease [...] Our selection of diseases, research initiatives, and medical treatments highlights larger patterns in medicine, identifies Canadian contributions, and considers the impact of these innovations on Canadian society. In this fifty–year period, public health initiatives limited the spread of contagious diseases and addressed the problem of impure water and milk. Medical practitioners used X–rays to diagnose tuberculosis and to treat cancer. The discovery of insulin in Toronto in 1921–22 offered a management therapy for diabetes patients, who were otherwise facing certain death.
Download or read book The Fault in Our Stars written by John Green and published by Penguin. This book was released on 2012-01-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beloved, #1 global bestseller by John Green, author of The Anthropocene Reviewed and Turtles All the Way Down “John Green is one of the best writers alive.” –E. Lockhart, #1 bestselling author of We Were Liars “The greatest romance story of this decade.″ –Entertainment Weekly #1 New York Times Bestseller • #1 Wall Street Journal Bestseller • #1 USA Today Bestseller • #1 International Bestseller Despite the tumor-shrinking medical miracle that has bought her a few years, Hazel has never been anything but terminal, her final chapter inscribed upon diagnosis. But when a gorgeous plot twist named Augustus Waters suddenly appears at Cancer Kid Support Group, Hazel’s story is about to be completely rewritten. From John Green, #1 bestselling author of The Anthropocene Reviewed and Turtles All the Way Down, The Fault in Our Stars is insightful, bold, irreverent, and raw. It brilliantly explores the funny, thrilling, and tragic business of being alive and in love.
Download or read book Twilight written by Stephenie Meyer and published by Little, Brown Books for Young Readers. This book was released on 2007-07-18 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fall in love with the addictive, suspenseful love story between a teenage girl and a vampire with the book that sparked a "literary phenomenon" and redefined romance for a generation (New York Times). Isabella Swan's move to Forks, a small, perpetually rainy town in Washington, could have been the most boring move she ever made. But once she meets the mysterious and alluring Edward Cullen, Isabella's life takes a thrilling and terrifying turn. Up until now, Edward has managed to keep his vampire identity a secret in the small community he lives in, but now nobody is safe, especially Isabella, the person Edward holds most dear. The lovers find themselves balanced precariously on the point of a knife -- between desire and danger. Deeply romantic and extraordinarily suspenseful, Twilight captures the struggle between defying our instincts and satisfying our desires. This is a love story with bite. It's here! #1 bestselling author Stephenie Meyer makes a triumphant return to the world of Twilight with the highly anticipated companion, Midnight Sun: the iconic love story of Bella and Edward told from the vampire's point of view. "People do not want to just read Meyer's books; they want to climb inside them and live there." -- Time "A literary phenomenon." -- The New York Times
Download or read book Pain in Infants Children and Adolescents written by Neil L. Schechter and published by Lippincott Williams & Wilkins. This book was released on 2003 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Second Edition is a significant revision of the leading text and clinical reference on pediatric pain. Written by an international group of experts from all relevant disciplines, this new edition is a vital reference for all pain practitioners, and for nurses, psychologists, PTs, anesthesiologists, and pediatricians dealing with acute and chronic pediatric pain. This edition includes new and expanded information on NSAIDs, opioids, and regional anesthesia. New chapters cover sedation, pain in the ICU, multidisciplinary pain services, palliative care, and the long-term consequences of pain. User-friendly new features include many more illustrations of techniques.
Download or read book A Vital Rationalist written by Georges Canguilhem and published by Princeton University Press. This book was released on 2000-04-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Georges Canguilhem is one of France's foremost historians of science. Trained as a medical doctor as well as a philosopher, he combined these practices to demonstrate to philosophers that there could be no epistemology without concrete study of the actual development of the sciences and to historians that there could be no worthwhile history of science without a philosophical understanding of the conceptual basis of all knowledge. A Vital Rationalist brings together for the first time a selection of Canguilhem's most important writings, including excerpts from previously unpublished manuscripts and a critical bibliography by Camille Limoges. Organized around the major themes and problems that have preoccupied Canguilhem throughout his intellectual career, the collection allows readers, whether familiar or unfamiliar with Canguilhem's work, access to a vast array of conceptual and concrete meditations on epistemology, methodology, science, and history. Canguilhem is a demanding writer, but Delaporte succeeds in marking out the main lines of his thought with unrivaled clarity; readers will come away with a heightened understanding of the complex and crucial place he holds in French intellectual history.
Download or read book Translation and Meaning written by Marcel Thelen and published by Lodz Studies in Language. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new and innovative ideas on the didactics of translation and interpreting. They include assessment methods and criteria, assessment of competences, graduate employability, placements, skills labs, the perceived skills gap between training and profession, the teaching of terminology, and curriculum design.
Download or read book Oxford Textbook of Palliative Medicine written by Nathan I. Cherny and published by Oxford University Press, USA. This book was released on 2015 with total page 1281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasising the multi-disciplinary nature of palliative care the fourth edition of this text also looks at the individual professional roles that contribute to the best-quality palliative care.
Download or read book Oxford Textbook of Palliative Care for Children written by Ann Goldman and published by Oxford University Press, USA. This book was released on 2012-05-24 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive in scope and definitive in authority, this second edition has been thoroughly updated to cover new practices, current epidemiological data and the evolving models that support the delivery of palliative medicine to children. This book is an essential resource for anyone who works with children worldwide.
Download or read book Frequently Asked Clinical Questions about Medical Abortion written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication contains answers to a range of frequently asked questions on medical abortion services, based on the discussions at an international conference held in Bellagio, Italy in November 2004. By focusing on practical issues, the answers should be particularly helpful to health-care personnel who are considering establishing, or already providing, a service for medical abortion in the early first trimester.
Download or read book An insight into the metabolism of New Psychoactive Substances written by Jakob Wallgren and published by Linköping University Electronic Press. This book was released on 2020-09-09 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. The use of NPS has been associated with many outbreaks leading to hospitalizations and has been implicated in numerous fatalities worldwide. To be able to analytically detect drugs in a forensic setting is vital in the fight against the abuse of NPS. One of the most notable challenges in detection of NPS is the identification of major urinary metabolites for use as biomarkers. Furthermore, given the lack of reference standards in most metabolism studies, the major urinary metabolites can often only be tentatively determined. This thesis describes the synthesis and analysis of potential metabolites used to identify the exact structures of major metabolites of the synthetic cannabinoid AKB-48, fentanyl and five fentanyl analogues in authentic human urine samples and/or hepatocyte incubations. Synthetic targets were chosen based on previous metabolism studies by our research group. Subsequently, synthetic routes were developed to produce numerous potential metabolites across the studied NPS. The synthesized reference standards were analyzed by LC-QTOF-MS alongside hepatocyte drug incubations and authentic human urine samples. Comparison of the resulting analytical data was used to determine the exact structures of many metabolites. This includes urinary metabolites of AKB-48 with a single hydroxyl group situated on a secondary carbon of the adamantane moiety, or position 3 or 5 of the pentyl side chain. For the studied fentanyls, the ?-OH and the 4’-OH metabolites were abundant metabolites identified in hepatocyte incubations while the 4’-OH, 4’-OH-3’-OMe and 3’,4’-diOH were the favored metabolic motifs among the metabolites identified in urine. Additionally, a concise synthetic route to produce synthetic cannabinoid metabolites with the 4-OH-5F pentyl side chain motif was developed and demonstrated for four synthetic cannabinoids. These findings and the developed synthetic routes can be used to provide forensic toxicology laboratories with urinary biomarkers for drug detection. Moreover, the synthesized reference standards of major metabolites can be studied to better understand the toxicity of their parent drugs. Nya psykoaktiva substanser (NPS) är det officiella namnet för den grupp droger som tidigare har kallats för designerdroger, nätdroger eller internetdroger. NPS definieras som droger som utgör ett likvärdigt hot mot folkhälsan som droger som återfinns på Förenta Nationernas narkotikakonventioner men som själva inte återfinns under dessa konventioner. Det finns hundratals olika rapporterade NPS spridda över olika droggrupper, såsom syntetiska cannabinoider och syntetiska opioider. Vissa av dessa droger syntetiserades ursprungligen i forskningssyfte, men tog sig senare in på den illegala drogmarknaden. De mer nyligen framtagna NPS är ofta designade att efterlikna effekterna av etablerade droger, såsom morfin eller ?9-THC, vilket är den huvudsakliga psykoaktiva substansen i cannabis. Användandet av NPS har associerats till många kluster av intoxikationer som har lett till hospitaliseringar. Många har även dött till följd av användandet av NPS. Inte minst i USA där en grupp av NPS kallad för fentanylanaloger är högst delaktig i den pågående opioidkrisen. Den ständiga inströmningen av nya NPS leder till att detektion av och diskriminering mellan dem utgör en svår utmaning för forensiska toxikologilaboratorier. Tillgången av lämpliga referenssubstanser möter inte deras efterfrågan, delvis på grund av att vilka biomarkörer som är optimala för drogdetektion inte alltid är uppenbart. Till exempel så är metabolismen av syntetiska cannabinoider i regel både snabb och omfattande. Av den anledningen kan användandet av modersubstansen som biomarkör vid analys av urin leda till falskt negativa resultat. Urin som biologisk matris har många fördelar jämfört med blod. Till exempel så har urin ett längre detektionsfönster och högre drogkoncentrationer. För att kunna identifiera optimala biomarkörer för droganalys av urinprover så måste drogernas metabolism utredas. De flesta metabolismstudier använder sig av humana levermikrosomer eller hepatocyter som inkuberas tillsammans med droger för att generera metaboliter in vitro. Urinprover från individer i vilkas blod det har återfunnits droger används också men tillgången är tyvärr begränsad. Dessa metaboliter separeras sedan med hjälp av kromatografiska tekniker och deras kemiska strukturer bestäms med hjälp av masspektrometri. Dock så är utvärderingen av masspektrometridata komplicerad och det är heller inte möjligt att skilja på vissa positionsisomerer genom att enbart analysera masspektrometridata. För att kunna möjliggöra exakt strukturutredning så krävs referensstandarder. Därför var målet med denna avhandling att addera syntes och analys av referensstandarder till de etablerade tillvägagångssätten att studera metabolismen av NPS. Ett stort antal potentiella metaboliter av AKB-48 och andra syntetiska cannabinoider samt av fentanyl och fentanylanaloger syntetiserades. Genom att använda dessa referensstandarder i metabolismstudier så kunde de exakta kemiska strukturerna för många metaboliter bestämmas. Dessutom så identifierades mönster i de metaboliska profilerna bland fentanyl och fentanylanaloger. Dessa mönster kan användas för att förbättra predikteringen av metaboliter för andra nuvarande och kommande fentanylanaloger. Dessa resultat samt de utvecklade syntesvägarna kan nyttjas i framställningen av referenssubstanser i syfte att användas som biomarkörer för att i urin kunna detektera drogmissbruk. Referenssubstanserna kan även användas för att studera metaboliternas farmakologiska egenskaper vilket kan leda till en djupare förståelse kring toxiciteten hos modersubstanserna.
Download or read book Ars De Statica Medicina written by Santorio Santorio and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock the secrets of the human body with this groundbreaking treatise on the principles of static medicine by Martin Lister and Santorio Santorio. Delving deep into the workings of the human body and the role of equilibrium in maintaining health, it provides an indispensable roadmap for medical professionals and laypeople alike. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Primary Pediatric Care written by Robert A. Hoekelman and published by Mosby Incorporated. This book was released on 2000-10-01 with total page 1936 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- An outstanding offer, both the New Hoekelman book & CD! -- Important new information at your fingertips, whether at the office or home.
Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Download or read book No Choice But to Deny who I Am written by Wendy Isaack and published by . This book was released on 2018 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
