Download or read book Bayesian Statistics the Fun Way written by Will Kurt and published by No Starch Press. This book was released on 2019-07-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fun guide to learning Bayesian statistics and probability through unusual and illustrative examples. Probability and statistics are increasingly important in a huge range of professions. But many people use data in ways they don't even understand, meaning they aren't getting the most from it. Bayesian Statistics the Fun Way will change that. This book will give you a complete understanding of Bayesian statistics through simple explanations and un-boring examples. Find out the probability of UFOs landing in your garden, how likely Han Solo is to survive a flight through an asteroid shower, how to win an argument about conspiracy theories, and whether a burglary really was a burglary, to name a few examples. By using these off-the-beaten-track examples, the author actually makes learning statistics fun. And you'll learn real skills, like how to: - How to measure your own level of uncertainty in a conclusion or belief - Calculate Bayes theorem and understand what it's useful for - Find the posterior, likelihood, and prior to check the accuracy of your conclusions - Calculate distributions to see the range of your data - Compare hypotheses and draw reliable conclusions from them Next time you find yourself with a sheaf of survey results and no idea what to do with them, turn to Bayesian Statistics the Fun Way to get the most value from your data.

Download or read book Bayesian Methods for Hackers written by Cameron Davidson-Pilon and published by Addison-Wesley Professional. This book was released on 2015-09-30 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master Bayesian Inference through Practical Examples and Computation–Without Advanced Mathematical Analysis Bayesian methods of inference are deeply natural and extremely powerful. However, most discussions of Bayesian inference rely on intensely complex mathematical analyses and artificial examples, making it inaccessible to anyone without a strong mathematical background. Now, though, Cameron Davidson-Pilon introduces Bayesian inference from a computational perspective, bridging theory to practice–freeing you to get results using computing power. Bayesian Methods for Hackers illuminates Bayesian inference through probabilistic programming with the powerful PyMC language and the closely related Python tools NumPy, SciPy, and Matplotlib. Using this approach, you can reach effective solutions in small increments, without extensive mathematical intervention. Davidson-Pilon begins by introducing the concepts underlying Bayesian inference, comparing it with other techniques and guiding you through building and training your first Bayesian model. Next, he introduces PyMC through a series of detailed examples and intuitive explanations that have been refined after extensive user feedback. You’ll learn how to use the Markov Chain Monte Carlo algorithm, choose appropriate sample sizes and priors, work with loss functions, and apply Bayesian inference in domains ranging from finance to marketing. Once you’ve mastered these techniques, you’ll constantly turn to this guide for the working PyMC code you need to jumpstart future projects. Coverage includes • Learning the Bayesian “state of mind” and its practical implications • Understanding how computers perform Bayesian inference • Using the PyMC Python library to program Bayesian analyses • Building and debugging models with PyMC • Testing your model’s “goodness of fit” • Opening the “black box” of the Markov Chain Monte Carlo algorithm to see how and why it works • Leveraging the power of the “Law of Large Numbers” • Mastering key concepts, such as clustering, convergence, autocorrelation, and thinning • Using loss functions to measure an estimate’s weaknesses based on your goals and desired outcomes • Selecting appropriate priors and understanding how their influence changes with dataset size • Overcoming the “exploration versus exploitation” dilemma: deciding when “pretty good” is good enough • Using Bayesian inference to improve A/B testing • Solving data science problems when only small amounts of data are available Cameron Davidson-Pilon has worked in many areas of applied mathematics, from the evolutionary dynamics of genes and diseases to stochastic modeling of financial prices. His contributions to the open source community include lifelines, an implementation of survival analysis in Python. Educated at the University of Waterloo and at the Independent University of Moscow, he currently works with the online commerce leader Shopify.

Download or read book Bayesian Statistics for Experimental Scientists written by Richard A. Chechile and published by MIT Press. This book was released on 2020-09-08 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the Bayesian approach to statistical inference that demonstrates its superiority to orthodox frequentist statistical analysis. This book offers an introduction to the Bayesian approach to statistical inference, with a focus on nonparametric and distribution-free methods. It covers not only well-developed methods for doing Bayesian statistics but also novel tools that enable Bayesian statistical analyses for cases that previously did not have a full Bayesian solution. The book's premise is that there are fundamental problems with orthodox frequentist statistical analyses that distort the scientific process. Side-by-side comparisons of Bayesian and frequentist methods illustrate the mismatch between the needs of experimental scientists in making inferences from data and the properties of the standard tools of classical statistics.

Download or read book Bayesian Applications in Pharmaceutical Development written by Mani Lakshminarayanan and published by CRC Press. This book was released on 2019-11-07 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2.6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development, from discovery, to clinical trial, to manufacturing with practical examples. This book will have a wide appeal to statisticians, scientists, and physicians working in drug development who are motivated to accelerate and streamline the drug development process, as well as students who aspire to work in this field. The advantages of this book are: Provides motivating, worked, practical case examples with easy to grasp models, technical details, and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting, as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles, technical reports, and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University, Dallas, Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process.

Download or read book Bayesian Inference for Gene Expression and Proteomics written by Kim-Anh Do and published by Cambridge University Press. This book was released on 2006-07-24 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert overviews of Bayesian methodology, tools and software for multi-platform high-throughput experimentation.

Download or read book Bayesian Data Analysis Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

Download or read book Rational Descriptions Decisions and Designs written by Myron Tribus and published by Elsevier. This book was released on 2013-10-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rational Descriptions, Decisions and Designs is a reference for understanding the aspects of rational decision theory in terms of the basic formalism of information theory. The text provides ways to achieve correct engineering design decisions. The book starts with an understanding for the need to apply rationality, as opposed to uncertainty, in design decision making. Inductive logic in computers is explained where the design of the machine and the accompanying software are considered. The text then explains the functional equations and the problems of arriving at a rational description through some mathematical preliminaries. Bayes' equation and rational inference as tools for adjusting probabilities when something new is encountered in earlier probability distributions are explained. The book presents as well a case study concerning the error made in following specifications of spark plugs. The author also explains the Bernoulli trials, where a probability that a better hypothesis than that already adopted may exist. The rational measure of uncertainty and the principle of maximum entropy with sample calculations are included in the text. After considering the probabilities, the decision theory is taken up where engineering design follows. Examples regarding transmitter and voltmeter designs are presented. The book ends by explaining probabilities of success and failure as applied to reliability engineering, that it is a state of knowledge rather than the state of a thing. The text can serve as a textbook for students in technology engineering and design, and as a useful reference for mathematicians, statisticians, and fabrication engineers.

Download or read book Bayesian Analysis with R for Drug Development written by Harry Yang and published by CRC Press. This book was released on 2019-06-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is an iterative process. The recent publications of regulatory guidelines further entail a lifecycle approach. Blending data from disparate sources, the Bayesian approach provides a flexible framework for drug development. Despite its advantages, the uptake of Bayesian methodologies is lagging behind in the field of pharmaceutical development. Written specifically for pharmaceutical practitioners, Bayesian Analysis with R for Drug Development: Concepts, Algorithms, and Case Studies, describes a wide range of Bayesian applications to problems throughout pre-clinical, clinical, and Chemistry, Manufacturing, and Control (CMC) development. Authored by two seasoned statisticians in the pharmaceutical industry, the book provides detailed Bayesian solutions to a broad array of pharmaceutical problems. Features Provides a single source of information on Bayesian statistics for drug development Covers a wide spectrum of pre-clinical, clinical, and CMC topics Demonstrates proper Bayesian applications using real-life examples Includes easy-to-follow R code with Bayesian Markov Chain Monte Carlo performed in both JAGS and Stan Bayesian software platforms Offers sufficient background for each problem and detailed description of solutions suitable for practitioners with limited Bayesian knowledge Harry Yang, Ph.D., is Senior Director and Head of Statistical Sciences at AstraZeneca. He has 24 years of experience across all aspects of drug research and development and extensive global regulatory experiences. He has published 6 statistical books, 15 book chapters, and over 90 peer-reviewed papers on diverse scientific and statistical subjects, including 15 joint statistical works with Dr. Novick. He is a frequent invited speaker at national and international conferences. He also developed statistical courses and conducted training at the FDA and USP as well as Peking University. Steven Novick, Ph.D., is Director of Statistical Sciences at AstraZeneca. He has extensively contributed statistical methods to the biopharmaceutical literature. Novick is a skilled Bayesian computer programmer and is frequently invited to speak at conferences, having developed and taught courses in several areas, including drug-combination analysis and Bayesian methods in clinical areas. Novick served on IPAC-RS and has chaired several national statistical conferences.

Download or read book Practical Applications of Bayesian Reliability written by Yan Liu and published by John Wiley & Sons. This book was released on 2019-03-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates how to solve reliability problems using practical applications of Bayesian models This self-contained reference provides fundamental knowledge of Bayesian reliability and utilizes numerous examples to show how Bayesian models can solve real life reliability problems. It teaches engineers and scientists exactly what Bayesian analysis is, what its benefits are, and how they can apply the methods to solve their own problems. To help readers get started quickly, the book presents many Bayesian models that use JAGS and which require fewer than 10 lines of command. It also offers a number of short R scripts consisting of simple functions to help them become familiar with R coding. Practical Applications of Bayesian Reliability starts by introducing basic concepts of reliability engineering, including random variables, discrete and continuous probability distributions, hazard function, and censored data. Basic concepts of Bayesian statistics, models, reasons, and theory are presented in the following chapter. Coverage of Bayesian computation, Metropolis-Hastings algorithm, and Gibbs Sampling comes next. The book then goes on to teach the concepts of design capability and design for reliability; introduce Bayesian models for estimating system reliability; discuss Bayesian Hierarchical Models and their applications; present linear and logistic regression models in Bayesian Perspective; and more. Provides a step-by-step approach for developing advanced reliability models to solve complex problems, and does not require in-depth understanding of statistical methodology Educates managers on the potential of Bayesian reliability models and associated impact Introduces commonly used predictive reliability models and advanced Bayesian models based on real life applications Includes practical guidelines to construct Bayesian reliability models along with computer codes for all of the case studies JAGS and R codes are provided on an accompanying website to enable practitioners to easily copy them and tailor them to their own applications Practical Applications of Bayesian Reliability is a helpful book for industry practitioners such as reliability engineers, mechanical engineers, electrical engineers, product engineers, system engineers, and materials scientists whose work includes predicting design or product performance.

Download or read book New Statistics for Design Researchers written by Martin Schmettow and published by Springer. This book was released on 2022-07-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design Research uses scientific methods to evaluate designs and build design theories. This book starts with recognizable questions in Design Research, such as A/B testing, how users learn to operate a device and why computer-generated faces are eerie. Using a broad range of examples, efficient research designs are presented together with statistical models and many visualizations. With the tidy R approach, producing publication-ready statistical reports is straight-forward and even non-programmers can learn this in just one day. Hundreds of illustrations, tables, simulations and models are presented with full R code and data included. Using Bayesian linear models, multi-level models and generalized linear models, an extensive statistical framework is introduced, covering a huge variety of research situations and yet, building on only a handful of basic concepts. Unique solutions to recurring problems are presented, such as psychometric multi-level models, beta regression for rating scales and ExGaussian regression for response times. A “think-first” approach is promoted for model building, as much as the quantitative interpretation of results, stimulating readers to think about data generating processes, as well as rational decision making. New Statistics for Design Researchers: A Bayesian Workflow in Tidy R targets scientists, industrial researchers and students in a range of disciplines, such as Human Factors, Applied Psychology, Communication Science, Industrial Design, Computer Science and Social Robotics. Statistical concepts are introduced in a problem-oriented way and with minimal formalism. Included primers on R and Bayesian statistics provide entry point for all backgrounds. A dedicated chapter on model criticism and comparison is a valuable addition for the seasoned scientist.

Download or read book Handbook of Design and Analysis of Experiments written by Angela Dean and published by CRC Press. This book was released on 2015-06-26 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt: This carefully edited collection synthesizes the state of the art in the theory and applications of designed experiments and their analyses. It provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook covers many recent advances in the field, including designs for nonlinear models and algorithms applicable to a wide variety of design problems. It also explores the extensive use of experimental designs in marketing, the pharmaceutical industry, engineering and other areas.

Download or read book Bayesian Adaptive Methods for Clinical Trials written by Scott M. Berry and published by CRC Press. This book was released on 2010-07-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti

Download or read book Uncertainty in Engineering written by Louis J. M. Aslett and published by Springer Nature. This book was released on 2022 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides an introduction to uncertainty quantification in engineering. Starting with preliminaries on Bayesian statistics and Monte Carlo methods, followed by material on imprecise probabilities, it then focuses on reliability theory and simulation methods for complex systems. The final two chapters discuss various aspects of aerospace engineering, considering stochastic model updating from an imprecise Bayesian perspective, and uncertainty quantification for aerospace flight modelling. Written by experts in the subject, and based on lectures given at the Second Training School of the European Research and Training Network UTOPIAE (Uncertainty Treatment and Optimization in Aerospace Engineering), which took place at Durham University (United Kingdom) from 2 to 6 July 2018, the book offers an essential resource for students as well as scientists and practitioners.

Download or read book Bayesian Optimization with Application to Computer Experiments written by Tony Pourmohamad and published by Springer Nature. This book was released on 2021-10-04 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to Bayesian optimization, highlighting advances in the field and showcasing its successful applications to computer experiments. R code is available as online supplementary material for most included examples, so that readers can better comprehend and reproduce methods. Compact and accessible, the volume is broken down into four chapters. Chapter 1 introduces the reader to the topic of computer experiments; it includes a variety of examples across many industries. Chapter 2 focuses on the task of surrogate model building and contains a mix of several different surrogate models that are used in the computer modeling and machine learning communities. Chapter 3 introduces the core concepts of Bayesian optimization and discusses unconstrained optimization. Chapter 4 moves on to constrained optimization, and showcases some of the most novel methods found in the field. This will be a useful companion to researchers and practitioners working with computer experiments and computer modeling. Additionally, readers with a background in machine learning but minimal background in computer experiments will find this book an interesting case study of the applicability of Bayesian optimization outside the realm of machine learning.

Download or read book Information Science for Materials Discovery and Design written by Turab Lookman and published by Springer. This book was released on 2015-12-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with an information-driven approach to plan materials discovery and design, iterative learning. The authors present contrasting but complementary approaches, such as those based on high throughput calculations, combinatorial experiments or data driven discovery, together with machine-learning methods. Similarly, statistical methods successfully applied in other fields, such as biosciences, are presented. The content spans from materials science to information science to reflect the cross-disciplinary nature of the field. A perspective is presented that offers a paradigm (codesign loop for materials design) to involve iteratively learning from experiments and calculations to develop materials with optimum properties. Such a loop requires the elements of incorporating domain materials knowledge, a database of descriptors (the genes), a surrogate or statistical model developed to predict a given property with uncertainties, performing adaptive experimental design to guide the next experiment or calculation and aspects of high throughput calculations as well as experiments. The book is about manufacturing with the aim to halving the time to discover and design new materials. Accelerating discovery relies on using large databases, computation, and mathematics in the material sciences in a manner similar to the way used to in the Human Genome Initiative. Novel approaches are therefore called to explore the enormous phase space presented by complex materials and processes. To achieve the desired performance gains, a predictive capability is needed to guide experiments and computations in the most fruitful directions by reducing not successful trials. Despite advances in computation and experimental techniques, generating vast arrays of data; without a clear way of linkage to models, the full value of data driven discovery cannot be realized. Hence, along with experimental, theoretical and computational materials science, we need to add a “fourth leg’’ to our toolkit to make the “Materials Genome'' a reality, the science of Materials Informatics.

Download or read book An Application of Bayes Theorem as a Hypothesis selection Aid in a Complex Information processing System written by Jack F. Southard and published by . This book was released on 1964 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frontiers of Biostatistical Methods and Applications in Clinical Oncology written by Shigeyuki Matsui and published by Springer. This book was released on 2017-10-03 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.