Download or read book Using Animal Models In Biomedical Research A Primer For The Investigator written by Pierce K H Chow and published by World Scientific. This book was released on 2008-01-02 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical researchers. However, while both legislations and the practice of laboratory animal science have made great advances in the last decade and have impacted significantly on the use of animal models, this corpus of knowledge is not readily available in formats easily digestible to the average biomedical researcher. This book fills this gap in knowledge and provides material not easily sourced by the average biomedical researcher, such as current information on bioimaging, occupational health and biosafety, animal protocol design and histological-pathological support.
Download or read book Biomechanics of the Female Pelvic Floor written by Lennox Hoyte and published by Academic Press. This book was released on 2016-03-01 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women's health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists. - Contains contributions from leading bioengineers and clinicians, and provides a cohesive multidisciplinary view of the field - Covers causes, risk factors, and optimal treatment for pelvic floor biomechanics - Combines anatomy, imaging, tissue characteristics, and computational modeling development in relation to pelvic floor biomechanics
Download or read book The Laboratory Rat written by Patrick Sharp and published by CRC Press. This book was released on 2012-12-11 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal h
Download or read book Mesenchymal Stem Cells and Skeletal Regeneration written by Peter Giannoudis and published by Academic Press. This book was released on 2013-02-20 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal Stem Cells and Skeletal Regeneration covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. - Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialists - Provides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC research - Assists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book Drugs and a Methodological Compendium written by Vikrant Singh Rajput and published by Springer Nature. This book was released on 2023-09-23 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Download or read book Essentials for Animal Research written by B. Taylor Bennett and published by . This book was released on 1994 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Information Resources for Institutional Animal Care and Use Committees written by and published by . This book was released on 2000 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Using Animals in Intramural Research written by and published by . This book was released on 1999 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Download or read book Guide for the Care and Use of Laboratory Animals written by Institute for Laboratory Animal Research and published by National Academies Press. This book was released on 1996-08-06 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The Guide incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of animal use: Institutional policies and responsibilities. The committee discusses areas that require policy attention: the role and function of the Institutional Animal Care and Use Committee, protocols for animal care and use, occupational health and safety, personnel qualifications, and other areas. Animal environment, husbandry, and management. The committee offers guidelines on how to design and run a management program, addressing environment, nutrition, sanitation, behavioral and social issues, genetics, nomenclature, and more. Veterinary care. The committee discusses animal procurement and transportation, disease and preventive medicine, and surgery. The Guide addresses pain recognition and relief and issues surrounding euthanasia. Physical plant. The committee identifies design and construction issues, providing guidelines for animal-room doors, drainage, noise control, surgery, and other areas. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities--a resource of proven value, now updated and expanded. This revision will be important to researchers, animal care technicians, facilities managers, administrators at research institutions, policymakers involved in research issues, and animal welfare advocates.
Download or read book The Laboratory Nonhuman Primate written by Jeffrey D. Fortman and published by CRC Press. This book was released on 2001-09-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on over 50 years of combined experience, The Laboratory Nonhuman Primate provides a quick reference source for technicians working with non-human primates in biomedical research. It details basic information and frequently used procedures such as duties of animal husbandry, facility management, regulatory compliance, and technical procedure
Download or read book Book Review Index 2009 Cumulation written by Dana Ferguson and published by Book Review Index Cumulation. This book was released on 2009-08 with total page 1304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book Review Index provides quick access to reviews of books, periodicals, books on tape and electronic media representing a wide range of popular, academic and professional interests. The up-to-date coverage, wide scope and inclusion of citations for both newly published and older materials make Book Review Index an exceptionally useful reference tool. More than 600 publications are indexed, including journals and national general interest publications and newspapers. Book Review Index is available in a three-issue subscription covering the current year or as an annual cumulation covering the past year.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1989 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Biomedical Investigator s Handbook written by Foundation for Biomedical Research (Washington, D.C.) and published by . This book was released on 1987 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rodent Model as Tools in Ethical Biomedical Research written by Monica Levy Andersen and published by Springer. This book was released on 2015-11-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.
Download or read book Use of Laboratory Animals in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
