Download or read book Use of Positron Emission Tomography PET to Improve Radiation Dosimetry for Boron Neutron Capture Therapy BNCT written by Mohammad Khurram Khan and published by . This book was released on 1999 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.
Download or read book PET based Approach to Treatment Planning Systems An Improvement Towards Successful Boron Neutron Capture Therapy BNCT Essential for Energy and Health HFR High Flux Reactor Reactor Applications written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Download or read book Molecular Medicine written by and published by . This book was released on 2005 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary objective of the project was the development of in vivo methods for the detection and evaluation of tumors in humans. The project was focused on utilizing positron emission tomography (PET) to monitor the distribution and pharamacokinetics of a current boron neutron capture therapy (BNCT) agent, p-boronophenylalanine (BPA) by labeling it with a fluorine-18, a positron emitting isotope. The PET data was then used to develop enhanced treatment planning protocols. The study also involved the synthesis of new tumor selective BNCTagents that could be labeled with radioactive nuclides for the in vivo detection of boron.
Download or read book Boron Neutron Capture Therapy Treatment Planning Improvements written by John Timothy Goorley and published by . This book was released on 1998 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Use of 18F BPA PET Images and Image Registration to Enhance Radiation Treatment Planning for Boron Neutron Capture Therapy written by Mohammad Khurram Khan and published by . This book was released on 2002 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Patient Specific Treatment Planning Method for BNCT Utilizing MCNP and RayStation written by James M. Seekamp and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current boron neutron capture therapy (BNCT) treatment planning systems compute dose is several different ways. Many of these systems have chosen Monte Carlo N-Particle (MCNP) as their dose engine due to its widespread usage and verified results. Several of the MCNP based treatment planning systems use standard DICOM computed tomography (CT) files to voxelize and create the patient specific model in MCNP. From this point on boron concentrations must be assigned by tissue type. All bone in the model has the same boron concentration, all healthy tissue will be set to one concentration, and the target volume will be set to a different spatially homogeneous concentration. This work seeks to address these assumptions about boron concentration by also integrating positron emission tomography (PET) information into the model so that each voxel in the model has the correct boron concentration. This step improves the accuracy of the patient specific model which improves the accuracy of dose calculations. that this method is creating a patient specific model with non-homogeneous boron concentration and that the calculated dose distribution is reasonable. This method was also developed to use RayStation as its visual display interface to visualize doses, volumes, and dose volume histograms due its ease of use.
Download or read book Proceedings of the Topical Meeting on Radiation Protection for Our National Priorities written by and published by . This book was released on 2000 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book PET based Approach to Treatment Planning Systems written by Guiseppe G. Daquino and published by . This book was released on 2003 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Based Compounds written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2018-07-23 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Download or read book Transactions of the American Nuclear Society written by American Nuclear Society and published by . This book was released on 2000 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advanced Monte Carlo for Radiation Physics Particle Transport Simulation and Applications written by Andreas Kling and published by Springer Science & Business Media. This book was released on 2014-02-22 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the state of the art of Monte Carlo methods in radiation physics and particle transport simulation and applications. Special attention is paid to algorithm development for modeling, and the analysis of experiments and measurements in a variety of fields.
Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
Download or read book Physics in Radiation Oncology Self Assessment Guide written by Ping Xia, PhD and published by Springer Publishing Company. This book was released on 2015-09-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide & companion to the Radiation Oncology Self-Assessment Guide is a comprehensive physics review for anyone in the field of radiation oncology looking to enhance their knowledge of medical physics. It covers in depth the principles of radiation physics as applied to radiation therapy along with their technical and clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly ìflash cardî question and answer format with over 800 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The Guide is comprised of 14 chapters that lead the reader through the radiation oncology physics field, from basic physics to current practice and latest innovations. Aspects of basic physics covered include fundamentals, photon and particle interactions, and dose measurement. A section on current practice covers treatment planning, safety, regulations, quality assurance, and SBRT, SRS, TBI, IMRT, and IGRT techniques. A chapter unique to this volume is dedicated to those topics in diagnostic imaging most relevant to radiology, including MRI, ultrasound, fluoroscopy, mammography, PET, SPECT, and CT. New technologies such as VMAT, novel IGRT devices, proton therapy, and MRI-guided therapy are also incorporated. Focused and authoritative, this must-have review combines the expertise of clinical radiation oncology and radiation physics faculty from the Cleveland Clinic Taussig Cancer Institute. Key Features: Includes more than 800 questions with detailed answers and rationales A one-stop guide for those studying the physics of radiation oncology including those wishing to reinforce their current knowledge of medical physics Delivered in a ìflash cardî format to facilitate recall of key concepts and data Presents a unique chapter on diagnostic imaging topics most relevant to radiation oncology Content provided by a vast array of contributors, including physicists, radiation oncology residents, dosimetrists, and physicians About the Editors: Andrew Godley, PhD, is Staff Physicist, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland OH Ping Xia, PhD, is Head of Medical Physics and Professor of Molecular Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Download or read book The Modern Technology of Radiation Oncology written by Jake Van Dyk and published by Medical Physics Publishing Corporation. This book was released on 1999 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details technology associated with radiation oncology, emphasizing design of all equipment allied with radiation treatment. Describes procedures required to implement equipment in clinical service, covering needs assessment, purchase, acceptance, and commissioning, and explains quality assurance issues. Also addresses less common and evolving technologies. For medical physicists and radiation oncologists, as well as radiation therapists, dosimetrists, and engineering technologists. Includes bandw medical images and photos of equipment. Paper edition (unseen), $145.95. Annotation copyrighted by Book News, Inc., Portland, OR
