Download or read book Universes in Delicate Balance Chemokines and the Nervous System written by R.M. Ransohoff and published by Elsevier. This book was released on 2002-04-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue. This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts. The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis. Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.
Download or read book The Neurology of AIDS written by Howard E. Gendelman, MD and published by Oxford University Press. This book was released on 2011-11-29 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Download or read book Inflammatory Disorders of the Nervous System written by Alireza Minagar and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Download or read book The Nidoviruses written by Stanley Perlman and published by Springer Science & Business Media. This book was released on 2007-05-01 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years.
Download or read book Neuro inflammation in Neuronal Death and Repair written by Giacinto Bagetta and published by Elsevier. This book was released on 2007-07-25 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.
Download or read book The Neurology of AIDS written by Howard E. Gendelman and published by Oxford University Press, USA. This book was released on 2005 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurology of AIDS is a compilation of works addressing six major aspects of nervous system disease that commonly follows HIV-1 infection. This includes basic science; clinical science; neuropathology; therapy; neuropsychiatric and prospectives of disease provided by patients.
Download or read book Renal Cell Carcinoma written by Ronald Bukowski and published by Springer Science & Business Media. This book was released on 2009-02-08 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the second edition of their critically acclaimed book, Ronald Bukowski, Robert Motzer, and Robert Figlin have thoroughly updated and expanded their survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. A panel of internationally renowned contributors explores the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. The discussion includes the specific biology of selected target molecules or receptors and the various agents that inhibit these targets, including full chapters devoted to drugs that selectively inhibit receptor tyrosine kinases, such as sunitinib and axitinib. Further attention is paid to leading-edge strategies that target and inhibit tumor associated angiogenesis and block the vascular endothelial growth factor pathway. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Second Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by the pioneers of the field.
Download or read book Renal Cell Cancer written by Jean J. M. C. H. Rosette and published by Springer Science & Business Media. This book was released on 2008-07-10 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a state-of-the-art reference work covering every aspect of the field of renal cell cancer, from diagnostics to clinical management. It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. Associated topics such as pain management and palliative care are also covered. It is a vital reference tool for urologists, oncologists and radiologists alike, being the most comprehensive volume available on the subject.
Download or read book Multiple Sclerosis Therapeutics written by Eli Minkoff and published by CRC Press. This book was released on 2007-03-06 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the previous edition of this volume, there has been substantial progress in a number of areas of multiple sclerosis (MS) research. Although immunosuppressive treatments continue to be developed and refined, more targeted immunomodulatory therapies are surfacing as we learn more about how the immune system works in health an
Download or read book Lung Cancer Metastasis written by Venkateshwar Keshamouni and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.
Download or read book Chemokines and Complement written by Rita Marie Cowell and published by . This book was released on 2002 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Global Health written by Yawei Zhang and published by SAGE. This book was released on 2008-01-09 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Global Health is a comprehensive A to Z, inter-disciplinary, one-stop reference to a broad array of health topics worldwide. Encompassing four volumes with some 1,200 articles in 2000 pages, the encyclopedia covers all aspects of health, including physical and mental health entries, biographies of major doctors and researchers, profiles of medical institutions, organizations, and corporations, descriptions of drugs and operations, articles on national health policies, and thematic health topics in the humanities. Pedagogical elements of the encyclopedia include an in-depth chronology detailing advances in health through history, a glossary of health definitions, extensive cross-references to related topics, and thorough bibliographic citations.
Download or read book Signal Transduction and Communication in Cancer Cells written by H. Leon Bradlow and published by . This book was released on 2004 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: In these proceedings for an October 2003 conference, contributors update topics and relevant issues in cancer research and clinical oncology, such as genetics, genomics, proteomics, signals and translational research in neuroectodermal timors, biomolecular surveying of cell signals, cell-to-cell communication, signals transduced by environmental and endogenous sex steroids, signals and molecular targets in human cancer tissues and cells, cell migration and adhesion, gene expression and silencing, and rational approaches to the design of therapeutics targeting molecular markers in hematologic malignancies. Topics of short papers include the induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors and a report from a registry comparing rates of breast cancer in the city and province of Palermo. Annotation ©2005 Book News, Inc., Portland, OR (booknews.com).
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 2002 with total page 1356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Books In Print 2004 2005 written by Ed Bowker Staff and published by R. R. Bowker. This book was released on 2004 with total page 3274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scientific Report written by Scripps Research Institute and published by . This book was released on 2002 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Book Publishing Record written by and published by . This book was released on 2002 with total page 2068 pages. Available in PDF, EPUB and Kindle. Book excerpt:
