Download or read book Understanding the Oncolytic Virus OV Basis Therapy written by Dr. Hakim. K. Saboowala and published by Dr.Hakim Saboowala. This book was released on with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the “Oncolytic Virus (OV) Basis & Therapy.” Oncolytic viruses (OVs) are an emerging class of cancer therapeutics that offer the: · Benefits of selective replication in tumour cells, · Delivery of multiple eukaryotic transgene payloads, · Induction of immunogenic cell death and promotion of antitumour immunity, and · Tolerable safety profile that largely does not overlap with that of other cancer therapeutics. To date, four OVs and one non-oncolytic virus have been approved for the treatment of cancer globally although talimogene laherparepvec (T-VEC) remains the only widely approved therapy. Despite increasing research interest, a better understanding of the underlying biology of OVs is needed to enable the full therapeutic potential of these agents in patients with cancer. Thus, it is strived in this Booklet to precisely describe: ü Time-line History of oncolytic virus development, ü Mechanisms of Tumour Tropism, ü Mechanisms of action of virus destroying tumour cells and ü Inherent and engineered oncolytic viruses. Further, it is also attempted to describe on optimization of the use of OVs in clinical practice along with plenty of relevant IMAGES for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Download or read book Oncolytic Viruses Genetically Engineering the Future of Cancer Therapy written by Benjamin Gesundheit and published by Frontiers Media SA. This book was released on 2016-11-22 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Download or read book Oncolytic Virus written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Oncolytic Virus A virus is said to be oncolytic if it targets cancer cells for infection and then proceeds to destroy those cells. As a result of the oncolysis, infected cancer cells are being eliminated, which results in the production of additional infectious virus particles called virions, which further contribute to the elimination of the residual tumor. It is believed that oncolytic viruses not only induce the direct killing of tumor cells, but also activate the host's anti-tumor immune system responses. [Citation needed] [Citation needed] In addition to this, oncolytic viruses are able to influence the microenvironment of the tumor in a variety of different ways. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Oncolytic virus Chapter 2: Virotherapy Chapter 3: Virus latency Chapter 4: Herpes simplex virus Chapter 5: Tony Minson Chapter 6: Genetically modified virus Chapter 7: Pelareorep Chapter 8: Pexastimogene devacirepvec Chapter 9: Herpes simplex research Chapter 10: Jennerex Chapter 11: Talimogene laherparepvec Chapter 12: Oncolytic herpes virus Chapter 13: Oncolytic adenovirus Chapter 14: GL-ONC1 Chapter 15: Genelux Corporation Chapter 16: ONCOS-102 Chapter 17: Akseli Hemminki Chapter 18: Infected cell protein 34.5 Chapter 19: Oncolytic AAV Chapter 20: HSV epigenetics Chapter 21: Transgene (company) (II) Answering the public top questions about oncolytic virus. (III) Real world examples for the usage of oncolytic virus in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of oncolytic virus' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of oncolytic virus.
Download or read book Handbook of Oncobiology From Basic to Clinical Sciences written by R. C. Sobti and published by Springer Nature. This book was released on with total page 1584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of a Mathematical Model to Understand Design Improve Oncolytic Virus Therapies written by Cory Batenchuk and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncolytic viruses (OVs) are emerging as a potent therapeutic platform for the treatment of malignant disease. The tumor cells inability to induce antiviral defences in response to a small cytokine known as interferon (IFN) is a common defect exploited by OVs. Heterogeneity in IFN signalling across tumors is therefore a pillar element of resistance to these therapies. I have generated a mathematical model and simulation platform to study the impact of IFN on OV dynamics in normal and cancerous tissues. In the first part of my thesis, I used this model to identify novel OV engineering strategies which could be implemented to overcome IFN based resistance in tumor tissues. From these simulations, it appears that a positive feedback loop, established by virus-mediated expression of an interferon-binding decoy receptor, could increase tumor cytotoxicity without compromising normal cells. The predictions set forth by this model have been validated both qualitatively and quantitatively in in-vitro and in-vivo models using two independent OV strains. This model has subsequently been used to investigate OV attenuation mechanisms, the impact of tumor cell heterogeneity, as well as drug-OV interactions. Following these results, it became apparent that selectivity should equally be observed when overwhelming the cell with a non replicating virus. While normal tissues will clear this pseudo-infection rapidly, owing to their high baseline in antiviral products at the onset of infection, tumor cells with defective anti-viral pathways should not have readily available biomachinery required to degrade this pro-apoptotic signal. Recapitulated by the mathematical model, non-replicating virus-derived particles generated by means of UV irradiation selectively kill tumor cells in cultured cell lines and patient samples, leading to long term cures in murine models. Taken together, this thesis uses a novel mathematical model and simulation platform to understand, design & improve oncolytic virus-based therapeutics.
Download or read book Gene Therapy of Cancer written by Edmund C. Lattime and published by Academic Press. This book was released on 2013-08-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA
Download or read book Virotherapy written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Virotherapy Reprogramming viruses in order to cure illness is an example of virotherapy, which is a kind of treatment that makes use of biotechnology to turn viruses into therapeutic agents. Anti-cancer oncolytic viruses, viral vectors for gene therapy, and viral immunotherapy are the three primary subspecialties that fall under the umbrella term "virotherapy." Gene overexpression, gene knockout, and suicide gene delivery are the three distinct approaches that are used by these branches throughout the therapeutic process. Gene overexpression results in the addition of genetic sequences that make up for insufficient or nonexistent amounts of essential gene expression. Gene silencing or expression reduction may be achieved by gene deletion by using RNA-based techniques. The delivery of suicide genes involves the introduction of genetic sequences that trigger an apoptotic response in cells; this is often done in order to eliminate malignant growths. In a somewhat different setting, the term "virotherapy" may also refer to the use of viruses to cure certain medical problems by eliminating infections. This is one definition of the term. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Virotherapy Chapter 2: Gene therapy Chapter 3: Immunotherapy Chapter 4: Cancer vaccine Chapter 5: Chimeric antigen receptor T cell Chapter 6: Cancer immunotherapy Chapter 7: Oncolytic virus Chapter 8: Viral vector Chapter 9: Murine respirovirus Chapter 10: Oncolytics Biotech Chapter 11: Pelareorep Chapter 12: Molecular oncology Chapter 13: Pexastimogene devacirepvec Chapter 14: Talimogene laherparepvec Chapter 15: Oncolytic herpes virus Chapter 16: Oncolytic adenovirus Chapter 17: Measles virus encoding the human thyroidal sodium iodide symporter Chapter 18: Timeline of cancer treatment development Chapter 19: Julianna Lisziewicz Chapter 20: Oncolytic AAV Chapter 21: Viral vector vaccine (II) Answering the public top questions about virotherapy. (III) Real world examples for the usage of virotherapy in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of virotherapy' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of virotherapy.
Download or read book Understanding and Exploiting the Contribution of the Immune System to the Therapeutic Efficacy of Oncolytic Virotherapy with Vesicular Stomatitis Virus VSV written by Phonphimon Wongthida and published by . This book was released on 2010 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Advances in Cancer Research and Therapy written by Xin-Yuan Liu and published by Elsevier. This book was released on 2012-05-18 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.
Download or read book Targeted Cancer Treatment in Silico written by Natalia L. Komarova and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.
Download or read book Second Generation Cell and Gene Based Therapies written by Alain Vertes and published by Academic Press. This book was released on 2020-02-07 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies
Download or read book Cancer Immunology written by Nima Rezaei and published by Springer. This book was released on 2014-12-29 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
Download or read book Basic Immunology Functions and Disorders of the Immune System 6e Sae E Book written by Abul K Abbas, Mbbs and published by Elsevier India. This book was released on 2019-06-28 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Immunology: Functions and Disorders of the Immune System, 6e: SAE-E-book
Download or read book Basic Immunology E Book written by Abul K. Abbas and published by Elsevier Health Sciences. This book was released on 2019-01-25 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help students master this complex topic in the most efficient, effective manner possible. Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application. Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas. Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today’s understanding of the immune system. Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology. Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review. Evolve Instructor site with a downloadable image bank is available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Download or read book Cancer Causing Viruses and Their Inhibitors written by Satya Prakash Gupta and published by CRC Press. This book was released on 2014-05-16 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who di
Download or read book Scott Brown s Otorhinolaryngology and Head and Neck Surgery written by John C Watkinson and published by CRC Press. This book was released on 2018-06-12 with total page 3261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Available as a single volume and as part of the three volume set, Volume One of Scott-Brown's Otorhinolaryngology, Head and Neck Surgery 8e covers Basic Sciences, Endocrine Surgery, and Rhinology. With over 100 chapters and complemented by clear illustrations, the content focuses on evidence-based practice. Clinical coverage is further enhanced by a clear well designed colour page format to ensure easy learning and the esy assimilation of the most up to date material. Definitive coverage in a single volume, with e-version access included.
Download or read book Youmans and Winn Neurological Surgery E Book written by H. Richard Winn and published by Elsevier Health Sciences. This book was released on 2022-01-21 with total page 7439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. Each clinical section contains chapters on technology specific to a clinical area. Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
