Download or read book Fundamentals of Clinical Trials written by Lawrence M. Friedman and published by Springer Science & Business Media. This book was released on 1998 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.

Download or read book Clinical Trials written by Duolao Wang and published by Remedica. This book was released on 2006 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains statistics specifically for a medically literate audience. Readers gain not only an understanding of the basics of medical statistics, but also a critical insight into how to review and evaluate clinical trial evidence.

Download or read book Laxton s Building Price Book 2002 written by V B Johnson and published by Elsevier. This book was released on 2001-10-10 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laxton's gives you access to the most reliable and current data. All 250,000 price elements have been individually checked and updated for the 2002 edition so that your estimates are always accurate and cost competitive. Laxton's makes analytical estimating simple and straightforward by displaying a complete breakdown for all measured items under 10 separate headings, all on a single page. This shows you a complete price build-up at a glance - and gives you the option to make price adjustments wherever necessary. You can find the sections you need quickly and easily, via the special marker system on the front cover and page edges. The free CD with this price book contains Masterbill's ESTIMATOR software and fully resourced data on all the price elements in Laxtons. Not only does the CD offer fast and efficient pricing at the touch of a button, it gives details of all the resources required to do the job. Laxton's approximate estimating section gives all in pricing for quick reference on the cost of composite items such as floors helping you calculate the cost implications of using plywood sheeting rather than softwood boarding, for example. Laxton's Basic Price section gives you a quick price on hundreds of items - from concrete work to roofing materials - to save you going through hundreds of lists from suppliers, manufacturers and building merchants. Laxton's Brand and Trade Names section lists over 12,000 brands and trade names and company addresses to help you locate specific items. Latest wage rates, fees and allowances All 250,000 price elements checked and updated

Download or read book Clinical Epidemiology written by R. Brian Haynes and published by Lippincott Williams & Wilkins. This book was released on 2012-03-29 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of this popular text focuses on clinical-practice research methods. It is written by clinicians with experience in generating and answering researchable questions about real-world clinical practice and health care—the prevention, treatment, diagnosis, prognosis, and causes of diseases, the measurement of quality of life, and the effects of innovations in health services. The book has a problem-oriented and protocol-based approach and is written at an introductory level, emphasizing key principles and their applications. A bound-in CD-ROM contains the full text of the book to help the reader locate needed information.

Download or read book Design and Analysis of Clinical Trials written by Shein-Chung Chow and published by John Wiley & Sons. This book was released on 2008-12-04 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition of Design and Analysis of Clinical Trials "An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area." –Statistical Methods in Medicine A complete and balanced presentation now revised, updated, and expanded As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH). Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as: Clinical trials and regulations, especially those of the ICH Clinical significance, reproducibility, and generalizability Goals of clinical trials and target population New study designs and trial types Sample size determination on equivalence and noninferiority trials, as well as comparing variabilities Also, three entirely new chapters cover: Designs for cancer clinical trials Preparation and implementation of a clinical protocol Data management of a clinical trial Written with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.

Download or read book Technologies for diabetes written by Maurizio Delvecchio and published by Frontiers Media SA. This book was released on 2023-06-01 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Designing Clinical Research written by Stephen B. Hulley and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology and offers an updated syllabus for conducting a clinical research workshop.

Download or read book Advanced Parallel and Distributed Computing written by Yuan-Shun Dai and published by Nova Publishers. This book was released on 2007 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of parallel and distributed computing is undergoing changes at a breathtaking pace. Networked computers are now omnipresent in virtually every application, from games to sophisticated space missions. The increasing complexity, heterogeneity, largeness, and dynamism of the emerging pervasive environments and associated applications are challenging the advancement of the parallel and distributed computing paradigm. Many novel infrastructures have been or are being created to provide the necessary computational fabric for realising parallel and distributed applications from diverse domains. New models and tools are also being proposed to evaluate and predict the quality of these complicated parallel and distributed systems. Current and recent past efforts, made to provide the infrastructures and models for such applications, have addressed many underlying complex problems and have thus resulted in new tools and paradigms for effectively realising parallel and distributed systems. This book showcases these novel tools and approaches with inputs from relevant experts.

Download or read book Encyclopedia of Research Design written by Neil J. Salkind and published by SAGE. This book was released on 2010-06-22 with total page 1779 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.

Download or read book Evidence Based Practice of Anesthesiology written by Lee Fleisher and published by Elsevier Health Sciences. This book was released on 2009-04-21 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Practice of Anesthesiology, 2nd Edition, by Lee A. Fleisher, MD, summarizes the best available evidence concerning the most common clinical questions that anesthesiologists face every day, so you will have an informed basis for making effective patient management decisions. This edition covers 24 new topics and explores a full range of important issues in perioperative management -- discussing the clinical options, examining the relevant research, and presenting expert recommendations. It features the latest information on clinical situations and reviews all clinical options based on the most recent clinical trials, providing a valuable framework for translating evidence into practice. Explores key topics such as preoperative preparation, perioperative management, regional anesthesia, monitoring, cardiovascular anesthesia, neurosurgical anesthesia, obstetrical anesthesia, pediatric anesthesia, and pain, Uses a practical, consistent format in each chapter, providing an overview of the question under discussion... an outline of the available management options... a review of the relevant evidence... identification of areas of uncertainty... a summary of existing management guidelines... and the author's recommendations. Provides tables that summarize the available literature as well as the recommended clinical approaches at a glance. Covers routine care as well as complicated and special situations to prepare you for a full range of challenges. Provides the latest information on clinical situations and reviews all clinical options based on the most recent clinical trials, to provide a valuable framework for translating evidence into practice. Presents coverage of 24 new topics including use of ultrasound guidance for regional anesthesia, effectiveness of preoperative clinics, perioperative brain protection and risk factors for perioperative stroke, optimal postoperative analgesia, and many others to help you keep you up to date.

Download or read book Evidence based Orthopedics written by Mohit Bhandari and published by John Wiley & Sons. This book was released on 2011-10-13 with total page 1179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgical orthopedic procedures such as hip replacements, arthroscopy or knee replacements are surrounded by pre- and post-operative complications, and there are varying different methods for the procedures themselves. This book, for the first time, brings together the best evidence for treatments as well as any complications. Not only does it cover the evidence base for orthopedic surgery, but also orthopedic conditions requiring medical treatment, and pediatric orthopedics. Using the approved EBM methodology, and edited by teachers of evidence-based medicine, this is a genuine EBM textbook for all orthopedic specialists and trainees.

Download or read book Deep Brain Stimulation in Neurological and Psychiatric Disorders written by Daniel Tarsy and published by Springer Science & Business Media. This book was released on 2008-06-04 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book discusses today’s most current and cutting-edge applications of Deep Brain Stimulation (DBS). The book begins with reviews of the functional anatomy and physiology of motor and nonmotor aspects of the basal ganglia and their connections which underlie the application of DBS to neurological and psychiatric disorders. This is followed by proposed mechanisms of action of DBS based on functional neuroimaging and neurophysiologic studies in animals and man.

Download or read book Practical Considerations for Adaptive Trial Design and Implementation written by Weili He and published by Springer. This book was released on 2014-10-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.

Download or read book Eight Preposterous Propositions written by Robert Ehrlich and published by Princeton University Press. This book was released on 2021-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placebo cures. Global warming. Extraterrestrial life. Psychokinesis. In a time when scientific claims can sound as strange as science fiction--and can have a profound effect on individual life or public policy--assessing the merits of a far-out, supposedly scientific idea can be as difficult as it is urgent. Into the breach between helpless gullibility and unyielding skepticism steps physicist Robert Ehrlich, with an indispensable guide to making sense of "scientific" claims. A series of case studies of some of the most controversial (and for the judging public, deeply vexing) topics in the natural and social sciences, Ehrlich's book serves as a primer for evaluating the evidence for the sort of strange-sounding ideas that can shape our lives. A much-anticipated follow-up to his popular Nine Crazy Ideas in Science, this book takes up issues close to readers' everyday reality--issues such as global warming, the dangers of cholesterol, and the effectiveness of placebos--as well as questions that resonate through (and beyond) civic life: Is intelligent design a scientific alternative to evolution? Is homosexuality primarily innate? Are people getting smarter or dumber? In each case, Ehrlich shows readers how to use the tools of science to judge the accuracy of strange ideas and the trustworthiness of ubiquitous "experts." As entertaining as it is instructive, his book will make the work of living wisely a bit easier and more reliable for scientists and nonscientists alike.

Download or read book LAXTON S BUILDING PRICE BOOK 2007 written by V B Johnson and published by Elsevier. This book was released on 2006-10-16 with total page 1467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its 179th edition, Laxton’s has become a firm favourite in the UK Building Industry. With more prices and more in-depth build-ups, Laxton’s offers more practical and complete information than any other price book available This new edition takes into account major price variations that stem frm raw material costs in the last few months. * Higher-fuel costs have impacted on prices across the board, in particular costs of non-ferrous metals in increased * Copper sheet and pipe show prince increases of well above 50% in the last year, while zinc, lead and aluminium prices have also risen significantly * There are savings in plaster and drainage goods, prices are down All the prices in Laxton's are based on the new 3 year Construction Industry Joint council wage rate agreement that came into force at the end of June 2006 *Saving you time - comprehensive basic price and approximate estimating sections make putting together outline costings quicker and easier *Saving you effort - all the information you need on each measured item is clearly set out on a single page, with a full break down of costs *Saving you money - all 250,000 prices are individually checked and updated to make sure that your tender costs are precise

Download or read book Handbook of Statistical Methods for Randomized Controlled Trials written by KyungMann Kim and published by CRC Press. This book was released on 2021-08-23 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.

Download or read book Handbook of Adaptive Designs in Pharmaceutical and Clinical Development written by Annpey Pong and published by CRC Press. This book was released on 2016-04-19 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip