Download or read book Transformer The Deep Chemistry of Life and Death written by Nick Lane and published by W. W. Norton & Company. This book was released on 2022-07-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Download or read book Power Sex Suicide written by Nick Lane and published by OUP Oxford. This book was released on 2005-10-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford
Download or read book Life Ascending written by Nick Lane and published by Profile Books. This book was released on 2010-10-01 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the 2010 Royal Society Prize for science books Powerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples. Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.
Download or read book Life s Ratchet written by Peter M. Hoffmann and published by . This book was released on 2012-10-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.
Download or read book Oxygen written by Nick Lane and published by Oxford University Press, USA. This book was released on 2002 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.
Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Download or read book Wetware written by Dennis Bray and published by Yale University Press. This book was released on 2009-05-26 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A beautifully written journey into the mechanics of the world of the cell, and even beyond, exploring the analogy with computers in a surprising way” (Denis Noble, author of Dance to the Tune of Life). How does a single-cell creature, such as an amoeba, lead such a sophisticated life? How does it hunt living prey, respond to lights, sounds, and smells, and display complex sequences of movements without the benefit of a nervous system? This book offers a startling and original answer. In clear, jargon-free language, Dennis Bray taps the findings from the discipline of systems biology to show that the internal chemistry of living cells is a form of computation. Cells are built out of molecular circuits that perform logical operations, as electronic devices do, but with unique properties. Bray argues that the computational juice of cells provides the basis for all distinctive properties of living systems: it allows organisms to embody in their internal structure an image of the world, and this accounts for their adaptability, responsiveness, and intelligence. In Wetware, Bray offers imaginative, wide-ranging, and perceptive critiques of robotics and complexity theory, as well as many entertaining and telling anecdotes. For the general reader, the practicing scientist, and all others with an interest in the nature of life, this book is an exciting portal to some of biology’s latest discoveries and ideas. “Drawing on the similarities between Pac-Man and an amoeba and efforts to model the human brain, this absorbing read shows that biologists and engineers have a lot to learn from working together.” —Discover magazine “Wetware will get the reader thinking.” —Science magazine
Download or read book Ahead of the Curve written by Michael Levin and published by Iph001. This book was released on 2019-01-31 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popular conception of science is of a steady, upward climb of progress. The reality is not that simple. Highly significant discoveries often stay unrecognized for decades, particularly if they conflict with the current paradigm or extend it in ways hard to imagine at the time. Ahead of the Curve: Hidden breakthroughs in the biosciences is a fascinating collection of lost research that the editors believe are important scientific contributions.
Download or read book In Search of Cell History written by Franklin M. Harold and published by University of Chicago Press. This book was released on 2014-10-29 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive history of cell evolution “deftly discusses the definition of life” as well as cellular organization, classification and more (San Francisco Book Review). The origin of cells remains one of the most fundamental mysteries in biology, one that has spawned a large body of research and debate over the past two decades. With In Search of Cell History, Franklin M. Harold offers a comprehensive, impartial take on that research and the controversies that keep the field in turmoil. Written in accessible language and complemented by a glossary for easy reference, this book examines the relationship between cells and genes; the central role of bioenergetics in the origin of life; the status of the universal tree of life with its three stems and viral outliers; and the controversies surrounding the last universal common ancestor. Harold also discusses the evolution of cellular organization, the origin of complex cells, and the incorporation of symbiotic organelles. In Search of Cell History shows us just how far we have come in understanding cell evolution—and the evolution of life in general—and how far we still have to go. “Wonderful…A loving distillation of connections within the incredible diversity of life in the biosphere, framing one of biology’s most important remaining questions: how did life begin?”—Nature
Download or read book One Renegade Cell written by Robert A Weinberg and published by Basic Books. This book was released on 2008-08-04 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured. Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation. This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.
Download or read book On Space and Time written by Alain Connes and published by Cambridge University Press. This book was released on 2012-03-26 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gets to the heart of science by asking a fundamental question: what is the true nature of space and time?
Download or read book Oxygen written by Donald E. Canfield and published by Princeton University Press. This book was released on 2015-12-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable scientific story of how Earth became an oxygenated planet The air we breathe is twenty-one percent oxygen, an amount higher than on any other known world. While we may take our air for granted, Earth was not always an oxygenated planet. How did it become this way? Donald Canfield—one of the world's leading authorities on geochemistry, earth history, and the early oceans—covers this vast history, emphasizing its relationship to the evolution of life and the evolving chemistry of the Earth. Canfield guides readers through the various lines of scientific evidence, considers some of the wrong turns and dead ends along the way, and highlights the scientists and researchers who have made key discoveries in the field. Showing how Earth’s atmosphere developed over time, Oxygen takes readers on a remarkable journey through the history of the oxygenation of our planet.
Download or read book Eating the Sun written by Oliver Morton and published by Harper Collins. This book was released on 2009-11-17 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wherever there is greenery, photosynthesis is working to make oxygen, release energy, and create living matter from the raw material of sunlight, water, and carbon dioxide. Without photosynthesis, there would be an empty world, an empty sky, and a sun that does nothing more than warm the rocks and reflect off the sea. Eating the Sun is the story of a world in crisis; an appreciation of the importance of plants; a history of the earth and the feuds and fantasies of warring scientists; a celebration of how the smallest things, enzymes and pigments, influence the largest things, the oceans, the rainforests, and the fossil fuel economy. Oliver Morton offers a fascinating, lively, profound look at nature's greatest miracle and sounds a much-needed call to arms—illuminating a potential crisis of climatic chaos and explaining how we can change our situation, for better or for worse.
Download or read book So Simple a Beginning written by Raghuveer Parthasarathy and published by Princeton University Press. This book was released on 2022-02-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biophysicist reveals the hidden unity behind nature’s breathtaking complexity The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering. Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound. Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Download or read book Journey of the Mind How Thinking Emerged from Chaos written by Ogi Ogas and published by W. W. Norton & Company. This book was released on 2022-03-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two neuroscientists reveal why consciousness exists and how it works by examining eighteen increasingly intelligent minds, from microbes to humankind—and beyond. Why do you exist? How did atoms and molecules transform into sentient creatures that experience longing, regret, compassion, and even marvel at their own existence? What does it truly mean to have a mind—to think? Science has offered few answers to these existential questions until now. Journey of the Mind is the first book to offer a unified account of the mind that explains how consciousness, language, self-awareness, and civilization arose incrementally out of chaos. The journey begins three billion years ago with the emergence of the universe’s simplest possible mind. From there, the book explores the nanoscopic archaeon, whose thinking machinery consists of a handful of molecules, then advances through amoebas, worms, frogs, birds, monkeys, and humans, explaining what each “new” mind could do that previous minds could not. Though they admire the triumph of human consciousness, Ogi Ogas and Sai Gaddam argue that humans are hardly the most sophisticated minds on the planet. The same physical principles that produce human self-awareness are leading cities and nation-states to develop “superminds,” and perhaps planting the seeds for even higher forms of consciousness. Written in lively, accessible language accompanied by vivid illustrations, Journey of the Mind is a mind-bending work of popular science, the first general book to share the cutting-edge mathematical basis for consciousness, language, and the self. It shows how a “unified theory of the mind” can explain the mind’s greatest mysteries—and offer clues about the ultimate fate of all minds in the universe.
Download or read book The Arrow Of Time written by Roger Highfield and published by Random House. This book was released on 2015-06-30 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: In our century, the subject of time has become an area of serious inquiry for science. Theories that contain time as a simple quantity form the basis of our understanding of many scientific disciplines, yet the debate rages on: why does there seem to be a direction to time, an arrow of time pointing from past to future? In this authoritative and accessible Sunday Times bestseller, physical chemist Dr Peter Coveney and award-winning science journalist Dr Roger Highfield demonstrate that the common sense view of time agrees with the most advanced scientific theory. Time does in fact move like an arrow, shooting forward into what is genuinely unknown, leaving the past immutably behind. The authors make their case by exploring three centuries of science, offering bold reinterpretations of Newton’s mechanics, Einstein’s special and general theories of relativity, quantum mechanics, and advancing the insights of chaos theory. In their voyage through science the authors link apparently irreconcilable subjects, from Einstein’s obsession with causality to chaos theory, from Marvell’s winged chariot to that Monday morning feeling. Finally, drawing together the various interpretations of time, they describe a novel way to give it a sense of direction. And they call for a new fundamental theory to take account of the Arrow of Time. Foreword by Ilya Prigogine, Nobel laureate.
