Download or read book Transcriptional regulation of the LEE4 operon in enteropathogenic E coli written by Michael Bomier and published by . This book was released on 2000 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ler and H NS mediated transcriptional regulation of the LEE5 operon of enteropathogenic E coli written by Jonathan William Fowlkes and published by . This book was released on 2002 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Evaluation of Regulatory Factors Modulating the Expression of LEE4 in Enterohemorrhagic Escherichia Coli O157 written by Karla Ann Mesterhazy and published by . This book was released on 2006 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: The locus of enterocyte effacement (LEE) encoded operons (LEE1 - LEE5) enable enterohemorrhagic Escherichia coli (EHEC) O157:H7 to produce attaching and effacing lesions on intestinal cells (A/E). We have previously reported that hha-deleted EHEC O157:H7 up-regulated LEE4 through increased expression of ler, the regulatory gene encoded by the LEE1 operon. In the present study, we demonstrate that a transpositional insertion in clpXP abrogated the increased expression of the LEE4 in the hha-deleted strain. The loss of LEE4 up-regulation in an EHEC O157:H7 [Delta]hha, [Delta]clpXP mutant was restored by transposon insertions immediately upstream of grlR of the grlR-grlA operon, suggesting that grIR represses the expression of LEE4 in the absence of Hha and ClpXP. RT-PCR analysis revealed that grlR transcription increased by about 100-fold in strains lacking hha but remained the same in the presence or absence of clpXP thus indicating that hha acts as a negative regulator of grlR transcription. RT-PCR data also showed a 10-fold reduction in LEE4 transcription for EHEC O157:H7 [Delta]clpXP thus suggesting that the absence of clpXP resulted in an increased accumulation of GrlR and presumably Hha thereby causing an additional reduction in LEE4 transcription compared to that observed for LEE4 in EHEC O157:H7. Western blot analysis of the cell-free extracts of EHEC O157:H7 [Delta]clpXP revealed increased accumulation of Hha. Altogether, the results described in this report indicate that ClpXP is important for maintaining a critical intracellular pool of Hha, which in turn modulates transcription of grlR-grlA so that a basal level of transcription could continue through LEE4 and the other LEE operons.
Download or read book Transcriptional Regulation of the Escherichia Coli K 12 Cyn Operon written by Anne-Francoise Jacqueline Lamblin and published by . This book was released on 1993 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional Regulation of the Qua Operon of Escherichia Coli written by Ian J. Davies and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of gene expression in enteropathogenic bacteria Volume III written by Dongsheng Zhou and published by Frontiers Media SA. This book was released on 2023-05-12 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book E coli written by Michael Donnenberg and published by Elsevier. This book was released on 2002-10-09 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although most strains of E. coli bacteria are harmless and live in the intestines of healthy humans and animals, several strains can produce powerful toxins and cause severe illness in humans. This versatile pathogen is best known for being transmitted to humans through contaminated foods — such as undercooked meat and unpasteurized fruit juice — and has attracts much attention when serious outbreaks occur. E. coli is capable of causing a wide variety of diseases — from urinary tract infections to meningitis. A considerable amount of media coverage has recently been devoted to one particular strain of E. coli, responsible for an estimated 73,000 cases of infection and 61 deaths in the United States each year. Knowing more about the biology, the evolution, and the genetic basis of this pathogen is crucial to future prevention of infection and illness. Pathogenic E. coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. Pathogenic E. coli concludes with a presentation of virulance factors, common to two or more pathotypes. This unique collection presents timely and vital information on understanding the inner workings of E. coli, which will lend key insights into disease prevention research. - Single source of information of E. coli pathogenesis - Expert authors - Comprehensive coverage - Molecular mechanisms - Biology, evolution and genomics - Recent advances
Download or read book Regulation of Gene Expression in Enteropathogenic Bacteria Volume II written by Dongsheng Zhou and published by Frontiers Media SA. This book was released on 2021-01-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the success of this Research Topic http://journal.frontiersin.org/ researchtopic/3298/regulation-of-gene-expression-in-enteropathogenic-bacteria, we are happy to launch a second edition of the project. Pathogenic bacteria have evolved numerous strategies to survive in and to attack hosts, which can be reflected by transcriptional and posttranscriptional changes in specific genes especially including those encoding virulence determinants. Regulation of gene expression by regulatory proteins and non-coding RNAs enables the pathogens to adapt their metabolic needs and to coordinately express virulence determinants during different stages of infection.
Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.
Download or read book Principles of Bacterial Pathogenesis written by Eduardo A. Groisman and published by Academic Press. This book was released on 2001-01-09 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants. - Explains the basic principles of bacterial pathogenesis - Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans - Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors - Presents authoritative treatises of the major disease microorganisms
Download or read book Escherichia coli in the Americas written by Alfredo G. Torres and published by Springer. This book was released on 2016-10-14 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand this pathogen and provide feasible solutions to prevent, treat and reduce E. coli infections. The Latin American Coalition for Escherichia coli Research (LACER) was created as a multidisciplinary network of international research groups working with E. coli with the ultimate goal of advancing understanding of E. coli, and to prepare the next generation of American E. coli investigators. As such, this book compiles the knowledge of these investigators about E. coli, a commensal bacteria living inside its host, and a pathogen causing disease in animals and humans. Escherichia coli in the Americas contains a series of 15 chapters written by experts, covering basic concepts regarding the different categories of E. coli, including their environmental niche, virulence mechanisms, host reservoir, and disease outcomes, as well as diagnosis, vaccine development and treatment. This book's target audience include trainees and students learning about the basic and clinical aspects of E. coli pathogenesis, as well as experts around the globe who wish to learn more about this pathogen and the public health impact this bacteria has in America.
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.). and published by . This book was released on 2005 with total page 1360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathogenicity Islands and the Evolution of Pathogenic Microbes written by J. Hacker and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.
Download or read book Tracing Pathogens in the Food Chain written by Stanley Brul and published by Elsevier. This book was released on 2010-11-23 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successful methods for the detection and investigation of outbreaks of foodborne disease are essential for ensuring consumer safety. Increased understanding of the transmission of pathogens in food chains will also assist efforts to safeguard public health. Tracing pathogens in the food chain reviews key aspects of the surveillance, analysis and spread of foodborne pathogens at different stages of industrial food production and processing. Part one provides an introduction to foodborne pathogen surveillance, outbreak investigation and control. Part two concentrates on subtyping of foodborne pathogens, with chapters on phenoytypic subtyping and pulsed-field gel electrophoresis, as well as emerging methods. The vital topics of method validation and quality assurance are also covered. The focus in Part three is on particular techniques for the surveillance and study of pathogens, such as protein-based analysis, ribotyping and comparative genomics. Finally, Part four focuses on tracing pathogens in specific food chains, such as red meat and game, dairy, fish and shellfish. With its distinguished editors and international team of contributors, Tracing pathogens in the food chain is a standard reference for researchers, public health experts and food industry professionals concerned with the study and control of foodborne disease. - Reviews key aspects of the surveillance, analysis and spread of foodborne pathogens - Provides an overview of method validation and quality assurance - Examines the tracing of pathogens in specific food chains, such as red meat, game and dairy
Download or read book Food Biotechnology written by Anthony Pometto and published by CRC Press. This book was released on 2005-10-11 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and updated to reflect the latest research and advances available, Food Biotechnology, Second Edition demonstrates the effect that biotechnology has on food production and processing. It is an authoritative and exhaustive compilation that discusses the bioconversion of raw food materials to processed products, the improvement of food
Download or read book Enteropathogenic and enterohemorrhagic E coli ecology pathogenesis and evolution written by Elizabeth L. Hartland and published by Frontiers E-books. This book was released on with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enteropathogenic and enterohemorrhagic E. coli are important causes of gastrointestinal disease worldwide. As part of their pathogenesis, EPEC and EHEC cause a distinctive lesion on the intestinal mucosa known as an attaching and effacing (A/E) lesion. A/E lesion formation requires a type III secretion system that injects multiple effector proteins into the cell. Despite their shared mechanism of intestinal colonization, EPEC and EHEC exhibit substantial differences in epidemiology and clinical disease. In particular, EHEC produces a potent Shiga toxin that is associated with development of the haemolytic uremic syndrome (HUS), an acute form of renal failure. This Research Topic will examine interactions between attaching and effacing bacteria and the host cell, and discuss EPEC/EPEC ecology, genomics and animal models of disease. Articles will centre on pathogen evolution, novel adhesins, type III effector biology and bacterium-host responses during infection.
Download or read book The Universe of Escherichia coli written by Marjanca Starčič Erjavec and published by BoD – Books on Demand. This book was released on 2019-09-18 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The title of the book "The Universe of Escherichia coli" aims to present and emphasize the huge diversity of this bacterial species and our efforts to prevent the E. coli infections. As it is part of the gut microbiota, E. coli is a well-known commensal species, and probiotic E. coli strains are successfully used for improving host's health. Also many "workhorse" E. coli strain exist that are employed in laboratory and biotechnology settings. But certain E. coli strains can cause intestinal and also extraintestinal infections at many anatomical sites. Therefore many efforts are undertaken to prevent E. coli infections, among them food safety, vaccines, but also new antimicrobial agents are searched for.
