Download or read book Transcription Factors in Immunological Disease and Haematological Malignancies written by Tomokatsu Ikawa and published by Frontiers Media SA. This book was released on 2024-02-23 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are nuclear proteins that control the rate of gene expression, activating or repressing transcription in a context-dependent manner. These regulators lie at the heart of most cell fate decisions of immune cells, guiding the initiation and maintenance of lineage identity and controlling the cell-type-specific gene expression that underpins the unique functions of each immune cell lineage. As such transcription factors are of critical importance for a healthy immune system, with mutation of specific factors leading to immune dysregulation with immunodeficiency and autoimmunity. In addition, perturbation of transcription factors known to regulate immune cell function have been implicated in the genesis of haematological malignancies through chromosomal translocation, over-expression or genetic deletion.
Download or read book Regulation of Cancer Immune Checkpoints written by and published by . This book was released on 2020 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Download or read book Cancer Cell Lines written by Bernhard Ø Palsson and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes all human leukemia-lymphoma cell lines that have been established and that grow continuously under standardised in vitro conditions. These lines are derived from cells belonging to all the major hematopoietic cell lineages, i.e. B- and T-lymphocytes, natural killer cells, granulocytic cells and megakaryocytic cells. The clinical data, the culture conditions and the major phenotypic features of the cell lines are described with citations. This book is the first book describing human leukemia-lymphoma cell lines and will be of interest to scientists involved in the areas of hematology, oncology, immunology, molecular biology and cytogenetics. Cancer Cell Lines, Volumes 1-3: These 3 volumes provide a comprehensive text on the culture of established cell lines from every type of human cancer. The volumes provide a basic manual and reference resource for every cancer research scientist using human cancer cells.
Download or read book Drug Resistance in Leukemia written by Gert-Jan L. Kaspers and published by CRC Press. This book was released on 1993-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols.
Download or read book Stiehm s Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians Fills an increasingly deep gap in the information available to clinicians Presents both clinical management and scientific advances for immune deficiencies Provides a primary resource for physicians in the field of immunodeficiencies Includes website access to a range of videos relevant to the topics discussed
Download or read book Fetal Neonatal Hematology Oncology and Immunology written by MR Lokeshwar and published by JP Medical Ltd. This book was released on 2017-07-17 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns. Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions. The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders. Each topic explains new advances, all current treatment protocols, new drugs, and management approaches. Chapters are further enhanced by clinical images and tables. Key points Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches Includes discussion on neonatal malignancies and blood transfusion Highly illustrated with clinical images and tables
Download or read book EBV Infection and Human Primary Immune Deficiencies written by Isabelle Meyts and published by Frontiers Media SA. This book was released on 2020-03-23 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neoplastic Diseases of the Blood written by Peter H. Wiernik and published by Springer. This book was released on 2018-03-15 with total page 1323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this textbook integrates the history, epidemiology, pathology, pathophysiology, therapeutics, and supportive care of modern neoplastic hematopathology. Now in its sixth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. The textbook is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia, including chronic leukemias and related disorders, acute leukemias, myeloma and related disorders, and lymphomas, and the fifth section covering a variety of topics in supportive care. Chapters are presented in an accessible and easy-to-read layout, providing updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. Neoplastic Diseases of the Blood, Sixth Edition is an authoritative and indispensable resource for students, trainees, and clinicians, sure to distinguish itself as the definitive reference on this subject.
Download or read book Reviews in hematologic malignancies written by Alejandro Gru and published by Frontiers Media SA. This book was released on 2023-01-31 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reviews in hematologic malignancies 2023 written by Billy Jebaraj and published by Frontiers Media SA. This book was released on 2024-05-10 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Immunology E Book written by Robert R. Rich and published by Elsevier Health Sciences. This book was released on 2022-08-23 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. - Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. - Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. - Provides new genetics content focused on data applications. - Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. - Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. - Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. - Summarizes promising research and development anticipated over the next 5–10 years with "On the Horizon" boxes and discussions of translational research. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Download or read book Tending Adam s Garden written by Irun R. Cohen and published by Elsevier. This book was released on 2000-01-28 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tending Adam's Garden describes and explains the way in which our immune system works from a novel perspective. The book uses metaphors and examples to bring the immune system to life and explores the fundamental miracle of nature. Written in plain language for a broad audience, this book encompasses much more than just immunology, exploring more fundamental matters such as causality, information, energy, evolution, cognition and individuality, as well as the strategy of the immune system and its role in health and disease. - Provides a unique perspective on the immune system from one of the keenest scientific and philosophical brains in the world - Uses metaphors and case histories to explore themes in an accessible manner - Written in plain language requiring no specialized vocabulary or specific scientific background in the subject
Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essential Immunology for Surgeons written by Oleg Eremin and published by OUP Oxford. This book was released on 2011-04-28 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a huge increase in the knowledge and understanding of the immunological processes involved in surgical practice in recent years. Anaesthesiologists and intensive care physicians are increasingly recognising the significant derangements of immune function in the critically ill patient and the possible therapeutic approaches to manage such patients (including new approaches in transplantation rejections, novel vaccination strategies in cancer treatment, as well as a better understanding of the beneficial effects of standard chemotherapy). Written by recognised experts in their field from both the UK and the US, and extensively referenced for further reading, Essential Immunology for Surgeons provides a concise, up-to-date, and readable account of immunology in general and its translation into key areas of clinical practice. It provides the necessary foundation for a critical understanding of this essential and rapidly expanding area of biological science that underpins and explains the modern concepts of a range of diseases and conditions, encompassing autoimmunity, infection, trauma, cancer, nutrition, organ transplantation, and various forms of therapy. Previously published as Immunological Basis for Surgical Science and Practice, this fully-updated textbook is aimed predominantly at the surgical trainee, but will also be of value to undergraduate and postgraduate clinicians of any discipline who wish to have a better understanding and knowledge of the subject, as well as to researchers studying the various core topics discussed in the book.
Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1993 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cecil Essentials of Medicine E Book written by Edward J. Wing and published by Elsevier Health Sciences. This book was released on 2021-03-17 with total page 1339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. - New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. - Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. - Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. - Superb images and photographs vividly illustrate the appearance and clinical features of disease. - New chapters cover Women's Cancer and Transitions in Care from Children to Adults with Pulmonary Disease.
Download or read book Innate Immune Cell Therapy of Cancer written by Asha B. Pillai and published by Frontiers Media SA. This book was released on 2023-09-13 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
