Download or read book Transarterial Chemoembolization TACE written by Pierleone Lucatelli and published by Springer Nature. This book was released on 2023-10-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book thoroughly presents Transarterial Chemoembolization (TACE), a procedure representing the standard of care for several clinical oncological indications. Thanks to the considerable technological advances in the available instrumentation (guidewire, microcatheter, guiding imaging modalities) as well as the different platforms utilized to perform treatment (conventional TACE, drug eluted TACE, degradable starch microsphere TACE) indication for treatment has been broadened and results significantly improved. By clearly depicting the procedure, with technical details, advantages and limitations, the book provides a unique and most updated source on TACE procedures. Clinical cases regarding crucial parts of the procedure are also provided. Expert users as well as novel clinicians interested in the most recent aspects of this interventional radiology procedure will find in this book a valuable tool and guide for their clinical routine.
Download or read book Transarterial chemoembolization for hepatocellular carcinoma patients written by and published by Frontiers Media SA. This book was released on 2024-04-09 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transarterial Chemoembolization TACE Prior to Liver Transplantation Does it Add to Surgical Risk when Considering Marginal Grafts written by Amanda Boteon and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction:TACE is established tumour control measure in patients with hepatocellular carcinoma (HCC) prior to liver transplantation (LT). Loco-regional effects of TACE may adversely affect the technical aspects of LT, and hence implications for graft selection.Methods:Retrospective cohort study involving patients with HCC that underwent TACE before LT (TACE group) between January 2011 and December 2015. The outcome of this group was compared with patients that underwent LT for HCC but without preoperative TACE (NoTACE group). Post-transplant surgical morbidity was compared according to Clavien classification.Results:59 cases included in the TACE group were compared with 123 cases in the NoTACE group. TACE group had higher prevalence of ischaemia related native collateral damage (11.86% vs 0%; p=0.002), native hepatic artery occlusion identified at surgery (5.1% vs 0%;p=0.033) and adhesions between the necrotic tumour to adjacent structures (14.75% vs. 3.15%; p=0.005). Surgical morbidity rate was significantly higher in the TACE group considering Dindo-Clavien grade 2 complications (64.4% vs 47.2%; p=0.029), however this was not found for grade u2265 3 (45,8% vs 58,5%; p=0,105). Patients in the TACE group transplanted with grafts from donors after cardiac death had 8.7% 90-day mortality and 56.5% major complication rate compared to 6.7% and 65% for the NoTACE group (p=0.719 and p=0.475; respectively).Discussion:HCC patients undergoing TACE while in the LT waiting list may lead to complications related to the procedure experienced in the laparotomy, nevertheless it has not shown repercussions on the mortality and only partial impact at morbidity, even considering the use of marginal grafts.
Download or read book Monitoring Liver Function of Patients Undergoing Transarterial Chemoembolization TACE by a 13C Breath Test LiMAx written by Emona Barzakova and published by . This book was released on 2021* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Liver Cancer in the Middle East written by Brian I. Carr and published by Springer Nature. This book was released on 2021-09-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.
Download or read book IR Playbook written by Nicole A. Keefe and published by Springer Nature. This book was released on 2024 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated new edition is a comprehensive guide to interventional radiology (IR) for medical students, residents, early career attendings, nurse practitioners and physician assistants. The IR Playbook includes procedures, new and updated data, and new images, to stay on the cutting edge of IR. As a specialty, IR is constantly changing and evolving to apply newer technologies and techniques to a breadth of disease pathologies. This book addresses the growing need for a reference for trainees and early career professionals to gain a solid foundation. Let this book serve as your only resource from the first day you find out about IR to the day you take your certifying exam. One and done. The textbook is divided into two main sections, with many images and key point boxes throughout that offer high-yield pearls along with the specific How To's necessary for practice. The first section is designed to give readers an introduction to IR, including radiation safety, commonly used devices, patient care, and anatomy. The second portion is divided by procedure. These chapters cover pathophysiology, indications for treatment, as well as alternative treatments before delving into interventional therapy. This new edition has been fully updated throughout including several brand-new procedures and divided chapters to allow a more in depth look at several disease pathologies. IR Playbook gives medical students, residents, and trainees a full perspective of interventional radiology.
Download or read book Parametric Contrast Enhanced Ultrasound Evaluation of Transarterial Chemoembolization written by Minakshi Mohanty and published by . This book was released on 2015 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work investigates quantitative contrast enhanced ultrasound (CEUS) derived blood flow parameters for evaluating chemoembolization of hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and is becoming increasingly common. Liver transplant is the only cure with 70 percent 5 year survival rate. However, transplant requires the tumor to fall under the Milan criteria (less than 5cm or up to 3 nodules each less than 1cm) and the technique is limited by the availability of donors. Transarterial chemoembolization (TACE), currently, is a treatment option for non-resectable tumors. It involves the administration of drug eluting beads via catheter into the branch of the hepatic artery that feeds the tumor. These beads occlude the blood supply to the tumor and at the same time release chemotherapy, leading to necrosis of the tumor and reduction in its size. Presently, the effectiveness of TACE procedure is determined one month post embolization through the use of contrast enhanced magnetic resonance imaging (MRI) or computed tomography (CT) scans, by evaluating blood flow within the tumor. Early screening for effective chemoembolization with contrast-enhanced MRI has been proven ineffective due to an inability to adequately visualize the vasculature. An earlier estimation of treatment efficacy would provide clinicians more time and options for re-treatment. Additionally, a number of patients may have morbidities including renal insufficiency. These patients may develop nephrogenic systemic fibrosis, which is the necrosis of skin and the internal organs, on exposure to gadolinium (present in MRI contrast agents). This project proposes the use of contrast enhanced ultrasound (CEUS) for monitoring the effectiveness of transarterial chemoembolization. Ultrasound contrast agents are gas filled microbubbles, which are encapsulated within a thin elastic shell made of lipids. They have a diameter of 1-[mu]m. Due to their restriction to the vasculature, an absence of contrast within the tumor is expected in cases where complete embolization has been achieved. Earlier studies have shown that lack of detected agents as little as 2 days post procedure correlated with effective procedure. However, currently there is no established standard as to how many days post treatment should the follow up be conducted, or which contrast agent to use. Fourteen patients with 16 lesions scheduled for transarterial chemoembolization (TACE) of HCC using drug eluting beads provided informed consent to undergo CEUS exam prior to treatment, 2 weeks post treatment, and the morning of follow up (contrast enhanced MRI 1 month post TACE). Ultrasound was performed using a Sequoia 512 scanner with 4C1 probe (Siemens Medical Solutions, Mountain View, CA). CEUS data was acquired using Cadence Pulse Sequencing (Siemens) during bolus injection of 0.6-0.7 ml of Definity (Lantheus Medical Imaging, N. Billerica, MA). Motion compensation was performed and time intensity curves were generated on a pixel-by-pixel basis to create parametric images showing maximum signal intensity (MAX), time to peak intensity (TTP), perfusion (PER), and area under curve (AUC). These values were averaged over the tumor and expressed normalized relative to baseline. Results were then grouped by clinical diagnosis (fully treated (n=5), partially treated (n=5) or no change (n=6)) and compared at each time point. Parametric imaging was successfully performed on 10 lesions, while six were excluded due to inability to identify tumor. Significant difference was observed in the time to peak dataset 2 weeks post TACE between complete response and no response group (p=0.018). No significance was observed in maximum intensity, perfusion and area under curve dataset. In the time intensity parameters obtained 4 weeks post TACE, no significant difference was observed. In conclusion, time to peak currently appears to be a good quantitative CEUS parameter for evaluating the effectiveness of TACE treatment 2 weeks post treatment.
Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Download or read book Radiotherapy of Liver Cancer written by Jinsil Seong and published by Springer. This book was released on 2022-07-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on all aspects of radiotherapy for liver cancer, from the basic science to clinical practice. While demand for radiotherapy of liver cancer has been increasing, the guidance available to clinicians has remained limited. Radiotherapy of Liver Cancer aims to address this deficit on the basis of the best available evidence. The first two sections explain the relevant basic science and present detailed information on the available technologies and techniques, including the most recent advances. The radiotherapy strategies appropriate in different patient groups are then fully described, covering the use of ablative, adjuvant, neoadjuvant, and definitive radiotherapy, radiotherapy as a bridge to liver transplantation, and palliative radiotherapy. The final section addresses a range of specific issues of concern to the clinician. Radiotherapy of Liver Cancer will be an ideal reference for clinical radiation oncologists, radiation oncology residents, oncologists, and hepatologists.
Download or read book Survival Benefit of Transarterial Chemoembolization in Patients with Metastatic Hepatocellular Carcinoma a Single Center Experience written by Dominik Bettinger and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hepatobiliary Cancer written by Paul H. Sugarbaker and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: When one deals with cancer, the hepatobiliary malignancies present a chal lenge to the oncologists that can be characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocar cinoma, and gall bladder cancer present an array of problems but have two features in common. These are high morbidity and mortality with an overall poor result from treatment. Why is it that hepatobiliary cancer carries with it such a dismal prognosis? First of all, these diseases present, for the most part, in an advanced state. To this point in time the oncologist has had no help from early diagnosis or screening. Only the occasional patient followed by ultrasound or a tumor marker has the disease diagnosed in an asymptomatic state. By the time these diseases become symptomatic, curative treatment options have usually disappeared. Evolution has placed the liver in a protected position in order to avoid injury to the soft parenchyma. As with many other internal organs, the nerve supply is extremely limited. These two anatomic features result in a great lack of early warning signs of cancer.
Download or read book Radiology Secrets Plus E Book written by E. Scott Pretorius and published by Elsevier Health Sciences. This book was released on 2010-07-01 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiology Secrets Plus—a Secrets Series title in the new PLUS format—offers an easy-to-read, information-at-your-fingertips approach to radiology. Drs. E. Scott Pretorius and Jeffrey A. Solomon provide the expert perspective you need to grasp the nuances of this specialty. This new edition offers more information and expanded full color visual elements to provide an overall enhanced learning experience. All this, along with the popular question-and answer approach, makes it a perfect concise board review tool and a handy clinical reference. Maintains the popular and trusted Secrets Series® format, using questions and short answers for effective and enjoyable learning. Provides the most current overview and authoritative coverage of all topics thanks to contributions from an impressive list of experts in the field of radiology. Introduces the new PLUS format, with an expanded size and layout and full color for easier review, more information, and more visual elements for an overall enhanced experience. Provides the current standards of radiology practice through thorough updates to every chapter that reflect the most up-to-date information. Contains more, larger images (including new full color PET and CT images), to offer a clearer picture of what is seen is practice.
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Download or read book Laser induced Interstitial Thermotherapy written by Gerhard J. Müller and published by SPIE Press. This book was released on 1995 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malignant Liver Tumours Basic Concepts and Clinical Management written by F. Berr and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.
Download or read book Hepatocellular Carcinoma written by Kelly M. McMasters and published by Springer Science & Business Media. This book was released on 2010-11-30 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular Carcinoma: Targeted Therapy provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options. This volume also provides an up-to-date guide for treatment that explores not only traditional treatments, but newer investigational treatment options including, surgical resection, liver transplantation, ablation (radiofrequency, microwave), percutaneous ethanol or acetic acid injection, transarterial chemoembolization (TACE), intra-arterial radiation therapy, and systemic chemotherapy. Heptocellular Carcinoma: Targeted Therapy will be of great value to all health care professionals and trainees worldwide who have an interest in the diagnosis and treatment of HCC, including surgeons, medical oncologists, radiologists, radiation oncologists, and pathologists.
Download or read book Diagnostic Imaging Interventional Procedures E Book written by Brandt C. Wible and published by Elsevier Health Sciences. This book was released on 2017-07-25 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 100 interventional procedures, lavishly illustrated with 800+ outstanding medical images, highlight the second edition of this practical reference. Dr. Brandt C. Wible and his expert author team provide carefully updated information in a concise, bulleted format, keeping you current with recent advances in interventional radiology. Succinct text, outstanding illustrations, and up-to-date content make this title a must-have reference for trainees as well as seasoned interventionalists and vascular surgeons who need a single, go-to guide in this fast-changing area. Organized by procedure type and formatted for quick reference at the point of care Meticulously updated throughout, with new information on interventional oncology, including radioembolizaiton, transarterial chemoembolization, and percutaneous ablation; IVC filter placement and removal; stroke intervention; and venous recanalization and thrombolysis Hundreds of high-quality case images and graphics (many new to this edition) clearly demonstrate procedural steps, complications, treatment alternatives, variant anatomy, and more—all fully annotated to highlight the most important diagnostic information New chapters including lumbar puncture and myelogram and celiac plexus block Newly streamlined discussions of procedural steps create a simpler, more focused text designed for quick reference Updated expected outcomes from recent prominent literature Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
