Download or read book Traditional Medicine for Neuronal Health written by Surya Pratap Singh and published by Bentham Science Publishers. This book was released on 2023-03-09 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Download or read book PHARMACOLOGICAL EFFECTS OF MED written by Cho-Tsun Or and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Pharmacological Effects of Medicinal Herbs on Oxidative Stress Related Neurodegenerative Diseases" by Cho-tsun, Or, 柯楚浚, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Neurodegenerative diseases are characterized by progressive loss and altered functions of neurons. They include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD). Although there are approved drugs to treat neurodegenerative diseases, most of them only provide symptomatic improvement and have little or no impact on disease progression. Recent findings show that oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases. It could cause apoptosis of neurons. Therefore, rescuing neuronal cell death from oxidative stress challenges could be one of the important therapeutic strategies. Moreover, neural regeneration by neural stem cells is believed to be a potential method for functional recovery after neural damage. The first essential step of neural stem cell therapy is to allow the neural stem cells to survive and grow. Therefore, another aspect of treating neurodegenerative diseases is to search for agents which enhance proliferation of neural stem cells. Herbal medicine is increasingly being used in recent decades to enhance general health and well-being. In this project, three medicinal herbs including Ligusticum chuanxiong (LCX), Ganoderma lucidum (LCZ) and Cimicifuga racemosa (BC) were studied. In the first part of the study, the neuroprotective effects of the three medicinal herbs were tested. Among them, BC and LCX extracts were found to rescue PC12 cells from neuronal cell death induced by hydrogen peroxide (H2O2), as measured by MTT assays. Cim A and Z-lig, bioactive compounds of BC and LCX, respectively, also exerted the neuroprotective effects on PC12 and neuro-2a cells. Both compounds rescued the neuronal cell death via inhibition of apoptosis as measured by caspase-3 activity assays. As for the mechanisms involved, Cim A and Z-lig were found to increase H2O2-suppressed bcl-2 protein expression. Furthermore, Cim A and Z-lig suppressed the phosphorylation of p-38 but had no effect on phosphorylations of JNK, ERK and Akt in H2O2-stimulated neuronal cells. In the second part of the study, the effects of three medicinal herbs on proliferation of human H9-derived neural stem cells were tested. Only LCZ extracts could promote the proliferation of neural stem cells, as measured by MTT assays. It was further shown that LCZ extract enhanced the recovery after oxidative stress damage by H2O2 and nitric oxide. By a series of chemical separations, including solvent partition, column chromatography, and high performance liquid chromatography, a bioactive compound was isolated. It enhanced the proliferation of neural stem cells as measured by MTT and BrdU assays. The underlying mechanisms were investigated. It was found that Compound LCZ could induce the mRNA levels of CYP1B1 and HDAC9. However, these proteins did not play a role in enhanced proliferation of neural stem cells induced by Compound LCZ. Additionally, compound LCZ increased the phosphorylation of ERK but had no effect on phosphorylations of JNK, Akt and PI3K kinases. This activation of ERK correlated with the promotion of proliferation, as confirmed by an MEK inhibitor. Taken together, the study reveals that medicinal herbs LCX, BC and LCZ are potential drug candidates for treating oxidative stress related neurodegenerative diseases. Subjects: Materia medica Nervous system - Degeneration - T
Download or read book Nutraceuticals in Brain Health and Beyond written by Dilip Ghosh and published by Academic Press. This book was released on 2020-11-12 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer's, Parkinson's, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health.Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. - Addresses nutritional psychiatry and cognitive health at all stages of the lifespan - Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients - Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders - Explores the role of genomics and epigenetics, including discussion of the gut–brain axis
Download or read book Herbs and Nutrients for Neurologic Disorders written by Sidney J. Kurn and published by Simon and Schuster. This book was released on 2016-06-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to herbal and holistic medicine for brain health and neurologic disorders • Provides detailed herbal, antioxidant, and nutritional strategies for Alzheimer’s, Parkinson’s, multiple sclerosis, stroke, migraine, and seizures • Supported by scientific studies and years of successful clinical practice • Discusses potential side effects, counter-indications, and the proper dosages to reduce symptoms, slow disease progression, and lessen the chances of recurrence Numerous medical journals have published studies supporting the use of herbs and nutrients in the treatment of neurodegenerative disorders. Yet in practice most neurologists rarely include them as part of their protocols. In this practical guide, Sidney Kurn, M.D., and Sheryl Shook, Ph.D., explain how to safely and easily incorporate herbs, antioxidants, and nutritional supplements into the standard conventional treatments for 6 common neurologic disorders: Alzheimer’s, Parkinson’s, multiple sclerosis, stroke, migraine, and seizures. For each condition, the authors provide detailed strategies supported by scientific evidence and years of successful clinical practice. They examine the biochemical role of each recommended herb, nutrient, or antioxidant and discuss potential side effects, counter-indications, and proper dosages to reduce symptoms, slow disease progression, and--in the case of stroke, migraine, and seizures--lessen the chances of recurrence. The authors explore the nutrient deficiencies and physiological mechanisms, including inflammation, heavy metal toxicity, and mitochondrial dysfunction, that can cause oxidative injuries and initiate neurologic disorders. They reveal which common substances, such as aspartame and glutamate, can trigger these mechanisms at the cellular level and recommend specific herbs and antioxidants, such as turmeric, cannabinoids, resveratrol, and N-acetyl cysteine, to counteract their effects. They discuss the importance of sleep to overall well-being, especially for those suffering from neurologic disorders, and offer tips to help ensure a good night’s sleep. Integrating neuroscience, biochemistry, herbalism, and decades of clinical experience, the authors lay the scientific foundation for a holistic, naturopathic approach to neurologic disorders and a way to enhance the quality of life for those suffering from these conditions.
Download or read book Neuroprotective Effects of Phytochemicals in Neurological Disorders written by Tahira Farooqui and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Download or read book Neuronal Networks in Brain Function CNS Disorders and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: - How the brain carries out important tasks via networks - How these networks interact in normal brain function - Major mechanisms that control network function - The interaction of the normal networks to produce more complex behaviors - How brain disorders can result from abnormal interactions - How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. - Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant - Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders - Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Download or read book The Benefits of Natural Products for Neurodegenerative Diseases written by M. Mohamed Essa and published by Springer. This book was released on 2016-09-20 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Download or read book Traditional and Complementary Medicine written by Cengiz Mordeniz and published by BoD – Books on Demand. This book was released on 2019-12-11 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medicine has reached a point where the patient is not treated as a biopsychosocial-spiritual being but rather is seen as a virtual identity consisting of laboratory findings and images. More focus is placed on relieving the symptoms instead of curing the disease. Mostly, patients are turned into lifetime medication-dependent individuals. New medicines are needed to overcome the side effects, complications, resistance, and intolerance caused by pharmacological and interventional therapies. In hopes of drug-free and painless alternative treatments with fewer complications, there has been a trend to revisit traditional methods that have been dismissed by modern medicine. Traditional medicine has to be reevaluated with modern scientific methods to complement and integrate with evidence-based modern medicine.
Download or read book Pharmacological Properties of Plant Derived Natural Products and Implications for Human Health written by George E. Barreto and published by Springer Nature. This book was released on 2021-04-16 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.
Download or read book Liquorice written by Münir Öztürk and published by Springer. This book was released on 2018-03-19 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Licorice (Glycyrrhiza) is one of the most widely used in foods, herbal medicine and one of the extensively researched medicinal plants of the world. In traditional medicine licorice roots have been used against treating many ailments including lung diseases, arthritis, kidney diseases, eczema, heart diseases, gastric ulcer, low blood pressure, allergies, liver toxicity, and certain microbial infections. Licorice extract contains sugars, starch, bitters, resins, essential oils, tannins, inorganic salts and low levels of nitrogenous constituents such as proteins, individual amino acids, and nucleic acids. A large number of biologically active compounds have been isolated from Glycyrrhiza species, where triterpene, saponins and flavonoids are the main constitutes which show broad biological activities. The present book will discuss the botany, the commercial interests as well as the recent studies on the phytochemistry and pharmacology of licorice. It will also describe the side effects and toxicity of licorice and its bioactive components, an underrepresented subjects of importance. It will be the first book to present global perspectives of licorice in detail. It will serve as a carefully researched introduction for students, healthcare practitioners, botanists and plant biochemists; full of historical background and bridges the gap between botany, ecology, pharmacology, as well as treatment of diseases.
Download or read book Rasayana written by H.S. Puri and published by CRC Press. This book was released on 2002-10-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until relatively recently, much of the information on India's research into their medicinal plants has remained within India, mainly published within Indian journals. However, today the field of Ayurveda is expanding, with the integration of herbs and minerals discovered in other countries and the strengthening of academic knowledge networks worldw
Download or read book Plant derived Bioactives written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2020-05-11 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.
Download or read book WHO Monographs on Selected Medicinal Plants written by World Health Organization and published by World Health Organization. This book was released on 1999 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume in a series of monographs which are intended to promote information exchange and international harmonised standards for the quality control and use of herbal medicines. It contains scientific information on 30 selected plants, and each entry includes a pharmacopoeial summary for quality assurance purposes, information on its clinical application and sections on contraindications, pharmacology, safety issues, and dosage forms. It provides two cumulative indexes with entries in alphabetical order by plant name and according to the plant material of interest.
Download or read book Neuroanatomical Tract Tracing written by Laszlo Zaborszky and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.
Download or read book The Altruistic Brain written by Donald W. Pfaff and published by Oxford University Press, USA. This book was released on 2015 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Unlike any other study in its field, The Altruistic Brain synthesizes into one theory the most important research into how and why - by purely physical mechanisms - humans empathize with one another and respond altruistically."--Jacket.
Download or read book Brain Repair written by Donald G. Stein and published by Oxford University Press, USA. This book was released on 1997 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over a half million people each year suffer brain-damaging injuries and diseases--but the outlook for their eventual recovery is far more hopeful than it was just a short while ago. In Brain Repair, three internationally renowned neuroscientists team up to offer an intriguing and up-to-the-minute introduction to the explosive advances being made in the research, technology, and treatment of brain damage. The key to neuroscience's most exciting discoveries to date is a theory that is rapidly gaining adherents in the scientific community--the theory of neuroplasticity. Neuroplasticity stresses that cells throughout the brain can not only regenerate, but can adapt their function to assume critical roles once performed by damaged tissue. In clear, accessible language, the authors show us that the brain manufactures a host of complex chemicals that actually foster growth in damaged brain cells. We visit the laboratories where researchers are untangling the mystery of Parkinson's disease and trying to understand what goes wrong in stroke victims, and why some, thought permanently impaired, show remarkable improvements. In addition, they discuss how even today misguided ideas can adversely affect how physicians treat patients. And, along the way, they detail the fascinating history of how brain structure and functioning has been understood and studied, from prehistoric times to the present. A best-selling volume in France and Mexico, Brain Repair provides a vividly written, wide-ranging look at the leading edge of one of science's most exciting frontiers.
