Download or read book Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans written by Dayong Wang and published by Springer Nature. This book was released on 2022-01-20 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This book uses Caenorhabditis elegans as model animal to introduce the toxicity induction of toxicants at environmentally relevant concentrations under different conditions. It also discusses the systematic introduction of different molecular signaling pathways, as well as G protein coupled receptors and ion channels, in regulating the toxicity of toxicants at environmentally relevant concentrations. The intestinal, neuronal, and germline molecular networks required for the regulation of toxicity of toxicants at environmentally relevant concentrations is further introduced and discussed. This book aims at providing a systematic understanding of the knowledge system on toxicology at environmentally relevant concentrations in Caenorhabditis elegans. ”
Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria
Download or read book Reviews of Environmental Contamination and Toxicology Volume 237 written by W.P. de Voogt and published by Springer. This book was released on 2015-11-27 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book Exposure Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer Nature. This book was released on 2020-08-27 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans.
Download or read book Environmental Metabolomics written by Diana Alvarez-Munoz and published by Elsevier. This book was released on 2020-06-03 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed. Presents relevant and reliable information on the use of different analytical techniques for establishing the environmental metabolomics of polluted systems Includes a critical review of each central topic in every chapter, together with a bibliography and future trends Provides, for the first time, a global opinion and guide for achieving standardized results
Download or read book Target Organ Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer. This book was released on 2019-02-12 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.
Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Download or read book Nanotoxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer. This book was released on 2018-05-22 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs’ translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.
Download or read book Toxicology at Environmentally Relevant Concentrations in Caenorhabditis Elegans written by Dayong Wang and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book uses Caenorhabditis elegans as model animal to introduce the toxicity induction of toxicants at environmentally relevant concentrations under different conditions. It also discusses the systematic introduction of different molecular signaling pathways, as well as G protein coupled receptors and ion channels, in regulating the toxicity of toxicants at environmentally relevant concentrations. The intestinal, neuronal, and germline molecular networks required for the regulation of toxicity of toxicants at environmentally relevant concentrations is further introduced and discussed. This book aims at providing a systematic understanding of the knowledge system on toxicology at environmentally relevant concentrations in Caenorhabditis elegans. ".
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.
Download or read book Fluorinated Surfactants and Repellents Second Edition written by Erik Kissa and published by CRC Press. This book was released on 2001-02-09 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of the synthesis, problems, theories and applications of fluorinated surfactants, this second edition is updated with four new chapters on repellency and protection against soiling and staining and over 2900 references, equations, and drawings (800 more than the previous edition). It lists alphabetically and explores numerous applications of fluorinated surfactants. Called "...a most useful introduction to these fascinating materials" by the Journal of Dispersion Science and Technology and "...a coherent and stimulating handbook...the most useful book in the fluorinated surfactants field to date. Recommended." by the Journal of the Chemical Society, Faraday Transactions - this book is a source of factual data, methods of manufacture, and chemical structures for the surfactant scientist and user.
Download or read book Toxicology of Nanomaterials written by Yuliang Zhao and published by John Wiley & Sons. This book was released on 2016-08-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.
Download or read book Molecular Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer. This book was released on 2019-01-24 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.
Download or read book Environmental Toxicology and Toxicogenomics written by Xiaoping Pan and published by . This book was released on 2021 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.
Download or read book Soil Ecotoxicology written by Joseph Tarradellas and published by CRC Press. This book was released on 1996-12-23 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soils are receptacles for a wide range of hazardous chemicals generated by human activities. Whether or not this contamination is deliberate, accurate toxicity assessments are important for health and economic reasons. Soil Ecotoxicology discusses the sources, fate, and transport of hazardous chemicals in soils. The fate (biodegradation and modeling) and the potential impacts of pesticides on soil ecosystems are emphasized, and methodologies for performing toxicity assessments are provided.
