Download or read book Total Synthesis of Thielocin B1 as a Protein Protein Interaction Inhibitor of PAC3 Homodimer written by Kosuke Ohsawa and published by Springer. This book was released on 2015-01-13 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.
Download or read book Designer Biopolymers written by Ayae Sugawara-Narutaki and published by MDPI. This book was released on 2020-12-14 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has evolved sequence-controlled polymers, such as DNA and proteins, over its long history. The recent progress of synthetic chemistry, DNA recombinant technology, and computational science, as well as the elucidation of molecular mechanisms in biological processes, drive us to design ingenious polymers that are inspired by naturally occurring polymers, but surpass them in specialized functions. The term “designer biopolymers” refers to polymers which consist of biological building units, such as nucleotides, amino acids, and monosaccharides, in a sequence-controlled manner. This book particularly focuses on the self-assembling aspect of designer biopolymers. Self-assembly is one common feature in biopolymers that is used to realize their dynamic biological activities and is strictly controlled by the sequence of biopolymers. In a broad sense, the self-assembly of biopolymers includes a double-helix formation of DNA, protein folding, and higher-order protein assembly (e.g., viral capsids). Designer biopolymers are now going beyond what nature evolved: researchers have generated DNA origami, protein cages, peptide nanofibers, and gels. This book illustrates the latest interdisciplinary work on self-assembling designer biopolymers. As shown by this book, the self-assembly of biopolymers has a great impact on a variety of research fields, including molecular biology, neurodegenerative diseases, drug delivery, gene therapy, regenerative medicine, and biomineralization. Designer biopolymers will help researchers to better understand biological processes, as well as to create innovative molecular systems. We believe that this book will provide readers with new ideas for their molecular design strategies for frontier research.
Download or read book Protective Groups in Organic Synthesis written by Theodora W. Greene and published by . This book was released on 1981-05-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.
Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2007-02-16 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Download or read book Atlas of Soil Ascomycetes written by J. Guarro and published by . This book was released on 2012 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This compendium includes almost all presently known species of ascomycetes that have been reported in soil and which sporulate in culture. They constitute a very broad spectrum of genera belonging to very diverse orders, but mainly to the Onygenales, Sordariales, Eurotiales, Thelebolales, Pezizales, Melanosporales, Pleosporales, Xylariales, Coniochaetales and Microascales. The goal of this book is to provide sufficient data for users to recognise and identify these species. It includes the description of 146 genera and 698 species. For each genus a dichotomous key to facilitate species identification is provided and for each genus and species the salient morphological features are described. These descriptions are accompanied by line drawings illustrating the most representative structures. Light micrographs, supplemented by scanning electron micrographs and Nomarski interference contrast micrographs of most of the species treated in the book are also included. In addition, numerous species not found in soil but related to those included in this book are referenced or described. This book will be of value not only to soil microbiologists and plant pathologists concerned with the soilborne fungi and diseases, but also to anyone interested in identifying fungi in general, because many of the genera included here are not confined to soil. Since most of the fungi of biotechnological or clinical interest (dermatophytes, dimorphic fungi and opportunists) are soil-borne ascomycetes, the content of this book is of interest for a wide range of scientists."--pub. desc.
Download or read book Challenges in Synthetic Organic Chemistry written by Teruaki Mukaiyama and published by Oxford University Press, USA. This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the life's work of Professor Teruaki Mukaiyama, one of Japan's most important and respected synthetic organic chemists. It includes information on his early research into a wide range of reactions, including dehydration reactions, the use of organosulfur compounds, and oxidation-reduction condensations in peptide and nucleotide synthesis reagents, as well as an account of Mukaiyama's important work on the applications of titanium compounds in organic synthesis. Three final chapters review Mukaiyama's work in synthetic control, stereoselective synthesis of carbohydrates, the stereoselective aldol, and Michael reactions. This unique book makes accessible much research that has only been available in Japanese, and provides a rare account of the contributions of one of the world's leading chemists.
Download or read book Silver Catalysis in Organic Synthesis written by Chao-Jun Li and published by John Wiley & Sons. This book was released on 2018-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.
Download or read book Bacterial Chromatin written by Remus T. Dame and published by Springer Nature. This book was released on with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereoselective Synthesis written by Gary A. Molander and published by Thieme Chemistry. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonyl and imino groups are two of the most integral functional groups employed in organic synthesis. Specific topics discussed: reduction, alkylation, alkenylation, and arylation of these groups, as well as asymmetric aldol, Mannich, and Morita-Bayliss-Hillman reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)
Download or read book Hydrocarbon Chemistry written by George A. Olah and published by John Wiley & Sons. This book was released on 2003-09-10 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrocarbons and their transformations play major roles in chemistry as raw materials and sources of energy. Diminishing petroleum supplies, regulatory problems, and environmental concerns constantly challenge chemists to rethink and redesign the industrial applications of hydrocarbons. Written by Nobel Prize-winner George Olah and hydrocarbon expert Árpád Molnár, the completely revised and expanded Second Edition of Hydrocarbon Chemistry provides an unparalleled contemporary assessment of the field, presenting basic concepts, current research, and future applications. Hydrocarbon Chemistry begins by discussing the general aspects of hydrocarbons, the separation of hydrocarbons from natural sources, and the synthesis from C1 precursors with recent developments for possible future applications. Each successive chapter deals with a specific type of hydrocarbon transformation. The Second Edition includes a new section on the chemical reduction of carbon dioxide–focusing on catalytic, ionic, electrocatalytic, photocatalytic, and ezymatic reductions–as well as a new chapter on new catalysts and activation methods, combinatorial chemistry, and environmental chemistry. Other topics covered include: Major processes of the petrochemical industry, such as cracking, reforming, isomerization, and alkylation Derivation reactions to form carbon-heteroatom bonds Hydrocarbon oxidations Metathesis Oligomerization and polymerization of hydrocarbons All chapters have been updated by adding sections on recent developments to review new advances and results. Essential reading for practicing scientists in industry, polymer and catalytic chemists, as well as researchers and graduate students, Hydrocarbon Chemistry, Second Edition remains the benchmark text in its field.
Download or read book Protein Protein Interactions written by Michael D. Wendt and published by Springer. This book was released on 2012-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor
Download or read book Sendai Virus Vector written by Yoshiyuki Nagai and published by Springer Science & Business Media. This book was released on 2014-01-31 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.
