Download or read book Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B written by Xiao-Yu Sun and published by Springer Science & Business Media. This book was released on 2012-01-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Download or read book Total Synthesis of Variecolortides A C written by Christian Andreas Kuttruff and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Directed Study Toward the Total Synthesis of tecomanine Synthesis of Cyclic Ethers Utilizing a Cyclization Fragmentation Strategy written by Denise Ann Ockey and published by . This book was released on 1999 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of BU 479F and Alkene Metathesis in the Synthesis of Novel lactam Antibiotics written by Simon Baker and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
