Download or read book Total Knockout written by Taylor Morris and published by Simon and Schuster. This book was released on 2012-03-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: There's nothing ordinary about Lucia Latham - she gets straight A's, she's been middle school Class President for two years running and she's a great boxer - nothing is more fun than a good old sparring match with best friend Cooper, especially since she usually wins. In short, there are few things Lucia tackles that don't turn out exactly how she wants them. So at the beginning of her 8th grade year, Lucia has no reason to believe that things won't continue being easy - until she sticks her foot in her mouth in a HUGE way. Then it seems her carefully constructed world is crashing down around her. Can she regain her super star status or will she be forced to lower her expectations?

Download or read book Total Knockout Fitness written by Martin McKenzie and published by Human Kinetics. This book was released on 2014-01-28 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Knockout Fitness incorporates a blend of boxing, cardio, and cross-training to produce the ultimate total-body workout. Featuring full-color photos, step-by-step descriptions of exercises and fundamental boxing skills, and a DVD depicting workouts, variations, and training tips, this special package contains everything you need in order to burn calories, increase power and strength, sculpt muscles, and transform your body.

Download or read book The Handbook of Medicinal Chemistry written by Andrew Davis and published by Royal Society of Chemistry. This book was released on 2015-07-07 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Download or read book The Laboratory Mouse written by Hans Hedrich and published by Academic Press. This book was released on 2012-06-14 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. - Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research - Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology - Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Download or read book The Guide to Investigation of Mouse Pregnancy written by B. Anne Croy and published by Academic Press. This book was released on 2013-12-09 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Download or read book Infertility in the Male written by Larry I. Lipshultz and published by Cambridge University Press. This book was released on 2009-09-24 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively revised edition of the highly-respected reference book provides in-depth discussions on the latest developments in male reproductive medicine.

Download or read book Cell cell Interactions written by Tom P. Fleming and published by Oxford University Press, USA. This book was released on 2002 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions between cells are fundamental to biological processes. This title comprises ten chapters on cell-cell interactions and their role in biology and medicine.

Download or read book Fatty Acid and Lipotoxicity in Obesity and Diabetes written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-03-11 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Download or read book Vitamin D written by Martin Hewison and published by Academic Press. This book was released on 2017-12-14 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. - Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D - Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles - Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency - Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications

Download or read book Knockout CV written by John Lees and published by McGraw-Hill Education (UK). This book was released on 2013-09-16 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: "John Lees is a purveyor of sound, no nonsense career advice which delivers results, whatever your age or status." Carol Lewis, Business Features Editor, The Times It doesn't take months to learn how to write a CV that works, but it does take a few hours. This book is designed to take you through that process quickly, taking some short cuts, encouraging your readers to say one simple word: "yes". Features: Step by step approach to building a CV from scratch Detailed advice on getting bullet points and the profile right Example CVs, including entry level and executive CVs Demystifying of CV formats and styles, including 'hybrid', competency-based and functional CVs Drawing on over 25 years' experience of training recruiters, John Lees, author of the bestselling How To Get A Job You'll Love, is one of the UK's best known career strategists. In Knockout CV he shows you how to write CVs and cover letters that convey your strengths quickly and get you into the interview room. "A comprehensive and practical guide to building arelevant, evidence-based CV which will win the recruiter'sattention. Looks afresh at the role of your CV, the pitfalls to avoid and shares invaluable recruiter insights." Liz Mason, Associate Director, Alumni Career Services,London Business School, UK "You write a CV for a purpose: to get a job. Knockout CV works backwards from the desired result, analysing each feature of the CV from the perspective of impact on the decision-maker. No frills, no diversions, simply full of practical help." Shirley Anderson, HR Director, Talent and Reward, Pilkington Group Limited "This book is essential reading for anyone considering a career move or applying for another position. First impressions are so important and your CV really does have to stand out from all the rest. This is an excellent, practical guide which I believe will really make the difference to securing that interview." Christine Gaskell, Chair, Cheshire and Warrington Local Enterprise Partnership and former HR Director, Bentley Motors Ltd "John Lees leads you back to the basic document of so manyjob-hunting campaigns, and yet again opens your eyes to seethe real underlying principles. His clear and authoritative voice brings life back into what is often seen as a routine activity - CV writing - yet is so important in today's hyper-competitive job market. With his clear chapter objectives, insightful exercises (especially the 'CV data bank'), professional insights,and a healthy dose of humour, John Lees sets the standardfor modern CV writing." Matthias Feist, Head of Careers & Business Relations atRegent's University London, UK and Chair of PlaceNet: Placements in Industry Network "John has produced an honest and authentic approach to creating a winning CV which speaks to your strengths, and will make the difference to getting noticed and in front of the selection panel. Yes, you can expect to work some, however John's advice plus your investment in time will produce a great result with the critical bonus of mental and emotional clarity over your next (right) career move." Angella Clarke-Jervoise, Big 4 Partner Recruiter andInternational Career Coach Praise for John Lees' careers books: "When I read John's writing, two things happen. First, I feel as if he's standing right there, personally advising me. And second, I always come away thinking over the issue in a new way. It's a rare, but very useful, gift." Sarah Green, Associate Editor, Harvard Business Review "I know first-hand the joy that being in the right career can bring and I commend John Lees for his books and seminars which help other people do just that." Rosemary Conley CBE "John Lees is the Career Professional's professional; thedoyen of careers experts. His books and advice have helpedcountless numbers of people to enjoy better, more fulfilling careers." Dr Harry Freedman, Career and Business Strategist,Hanover Executive

Download or read book Recoding Expansion of Decoding Rules Enriches Gene Expression written by John F. Atkins and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.

Download or read book Single Membrane Channels Formed by Connexins or Pannexins Focus on the Nervous System written by Juan Andrés Orellana and published by Frontiers Media SA. This book was released on 2016-09-26 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. At this regard, paracrine signaling between neighboring cells is currently recognized as one of the most widely distributed mechanisms of synchronization in the brain parenchyma. In mammals, paracrine signaling is in part mediated by single membrane channels formed by connexins (connexons/hemichannels) or pannexins (pannexons), which are two different membrane protein families composed of about 20 and 3 members, respectively. Single membrane channels formed by these proteins serve as aqueous pores permeable to ions and small molecules, allowing the diffusional exchange between the intra- and extracellular milieu. Thus, connexin hemichannels and pannexons permit the release of significant quantities of autocrine/paracrine signaling molecules (e.g., ATP, glutamate, NAD+, adenosine and PGE2) into the extracellular milieu, as well as the uptake of small molecules. An increasing body of evidence has revealed that connexin hemichannels and pannexons play a crucial role in a plethora of brain processes including blood flow regulation, Ca2+ wave propagation, memory consolidation, glucose sensing and cell migration and adhesion. Considering the multiple cell signaling functions of these channels, their dysregulation is proposed not only as potential pathological biomarker, but it has been implicated in the pathogenesis and progression of diverse brain diseases (e.g., meningitis, Alzheimer’s disease and stroke). The aim of this Research Topic is to gather a collection of original research articles, method, protocols, short communications, opinions, perspectives, as well as review articles, providing the latest progress and insights in the field of connexin hemichannels and pannexons in the nervous system. Within this volume we plan to cover from basic research including channel structure, regulation, pharmacology and trafficking; to different biological functions in the physiology (behavior, plasticity, neurogenesis, blood flow control, neuron-glia crosstalk, cell migration and differentiation) as well as in the pathophysiology (neuroinflammation, mutation-related diseases, glial dysfunction and neurodegeneration) of the nervous system. We hope that this collection of articles will serve to understand how the signaling of connexin hemichannels and pannexons influences both normal and pathological brain function.

Download or read book Nutrition and Growth written by B. Koletzko and published by Karger Medical and Scientific Publishers. This book was released on 2016-02-25 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a well-known fact that children's growth depends on the quality of their nutrition. However, the mechanisms of fetal and child growth and their interactions with nutrition have not yet been fully elucidated and still pose a challenge to those engaged in the field. Exchanging concepts and knowledge among professionals of various disciplines thus remains very important. This second 'Yearbook' provides an update on the research published between 2013 and 2015. An international team of experts presents papers that shed light on the mechanisms of interaction between nutrition and growth, and provide insight to the readers. Each paper is briefly summarized and supplemented with editorial comments which evaluate the clinical importance of each article and discuss its application.This 'Yearbook' is an important tool for practicing physicians, including pediatricians, subspecialists in pediatric gastroenterology, metabolism and nutrition, and endocrinology. Nutritionists and dieticians, as well as other health professionals involved in the care of children, will also find this to be a useful resource.

Download or read book The Ultimate Joke Challenge written by Jimmy Niro and published by Sourcebooks, Inc.. This book was released on 2020-09-01 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Battle it out in this laugh-out-loud joke book for kids with 300+ jokes! A fun activity for the whole family and a hilarious Christmas gift for ages 5-7, 8-10, and 10-12. GOAL: Make your opponent laugh out loud and don't laugh yourself—we dare you! In this ultimate showdown, players compete in multi-level rounds with hilarious charades for kids, fill-in-the-blanks, knock-knock jokes, tongue-twisters, shout challenges, mumble challenges, and more. Each laugh you get earns you a point, and the person who gets the most laughs is crowned the Jokestar Champion! This clean, screen-free time game book is epic fun for the whole family. Just try not to laugh! A perfect gift idea for: Funny gifts for kids—boys and girls—for birthdays, family game nights, road trips, sleepovers, Christmas gift, and more! Reluctant young readers with funny content that engages the imaginations of reluctant and beginner readers, helping them gain confidence and build vocabulary and reading comprehension Silly white elephant gag gifts or stocking stuffers for kids and families

Download or read book This Is Me From Now On written by Barbara Dee and published by Simon and Schuster. This book was released on 2010-04-27 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: In This Is Me From Now On, Evie’s new friend Francesca thinks life is dull unless you go after and say whatever you want. Evie can’t always tell if she’s horrified or fascinated by everything Francesca convinces her to do, but she ultimately comes to understand friendship on a whole new level.

Download or read book Feldman and Pike s Vitamin D written by Martin Hewison and published by Elsevier. This book was released on 2023-10-28 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike's Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. • A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field

Download or read book Brenner and Rector s The Kidney E Book written by Alan S. L. Yu and published by Elsevier Health Sciences. This book was released on 2019-09-25 with total page 3753 pages. Available in PDF, EPUB and Kindle. Book excerpt: Put the world's most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector's The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. - Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. - Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. - Discussions of today's hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. - New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. - New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. - Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. - A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zürich. - Board review-style questions to help you prepare for certification or recertification. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices