Download or read book Time Resolved Spectral Optical Breast Tomography written by and published by . This book was released on 2003 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research carried out during the current reporting period involved: (a) developing and enhancing the 3D tomographic image reconstruction algorithm to use a L-curve method guided by the signal-to-noise ratio of the data set to determine the regularization parameter; (b) developing and enhancing the 3D tomographic image reconstruction algorithm to make use of spectral information in multiple wavelength measurements; (c) developing a novel information theory approach to analyze the data set for image reconstruction; and (d) extending the range of applicability of the linear inversion scheme for optical imaging using a nonlinear correction factor for inhomogeneities strong in absorption. The L-curve method guided by the signal-to-noise ratio of the data set and the information theory approach using independent component analysis to analyze the data set were found to improve the quality of image reconstruction. The correction for the nonlinear effect of the multiple passages of an absorption site by light was shown to be essential in optical imaging to characterize properly inhomogeneities strong in absorption. The theoretical formalism and computer algorithm for 3D tomographic image reconstruction shows with simulated data and preliminary experimental data the potential to provide fast 3D images of the scattering and absorption objects at various depths in turbid media.
Download or read book Time Resolved and Spectroscopic Three Dimensional Optical Breast Tomography written by and published by . This book was released on 2009 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the research project, "Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography," was to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared (NIR) light for imaging and diagnosing tumors in human breast with high resolution and specificity. In order to realize that goal three different approaches were developed. These are Optical Tomography using Independent Component Analysis (OPTICA), Round Trip Matrix (RTM) approach, and Center of Intensity Time Gated Imaging (CITGI). OPTICA is the most developed of these approaches. It has been demonstrated that OPTICA can detect, obtain the threedimensional location information and cross-section images of small absorbing, scattering, and fluorescent targets in model media, and tumor(s) in realistic model breast with considerable accuracy. Further accomplishments include development of a forward model for determining the backscattered polarized light intensity distribution, and initial development of a technique to determine scattering coefficient, absorption coefficient, and anisotropy factor (g) of breast tissue specimens. Besides detection and localization of tumors in breast, these results may have potential applications in optical biopsy, and lumpectomy. The graduate student supported by the project received his Ph. D., adding another scientist to the ongoing fight against breast cancer.
Download or read book Optical Tomography and Spectroscopy of Tissue VII written by Britton Chance and published by SPIE-International Society for Optical Engineering. This book was released on 2007 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory/Algorithm/Modeling; Instrumentation and Technology I; Fluorescence Imaging/Spectroscopy (algorithm/model/tomography); Fluorescence Imaging/Image Reconstruction (Experimental); Instrumentation and Technology II; Fluorescence Imaging Technology I; Fluorescence Imaging Technology II; Fluorescence Imaging Technology III; Network for Translational Research in Optical Imaging: Breast Cancer Diffuse Optical Imaging; Breast II - Instrumentation & New Analysis Method; Breast III - Clinical Study; Pre-Clinical/Animal; Instrumentation and Technology III; Clinical/Human Subject Studies.
Download or read book New Horizons in Time Domain Diffuse Optical Spectroscopy and Imaging written by Yoko Hoshi and published by MDPI. This book was released on 2020-06-23 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.
Download or read book Medical Optical Tomography written by Gerhard J. Müller and published by SPIE-International Society for Optical Engineering. This book was released on 1993 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Optical Biopsy and Optical Mammography written by Robert R. Alfano and published by . This book was released on 1998 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a conference by the New York Academy of Sciences held in 1997. The papers explore optical biopsy and optical mammography - new techniques that allow investigators to determine whether a tissue is cancerous without using invasive techniques. The text offers an analysis of the spectrum light emitted from optically excited tissue which allows investigators to detect physical and chemical changes in tissue and determine whether the tissue is normal, benign or cancerous.
Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-07-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
Download or read book Time Resolved Optical Tomography for the Detection and Specification of Breast Disease written by Tara Dawn Yates and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Optical Imaging for Clinical Medicine written by Nicusor Iftimia and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
Download or read book Proceedings of Optical Tomography and Spectroscopy of Tissue III written by Britton Chance and published by SPIE-International Society for Optical Engineering. This book was released on 1999 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Emerging Imaging Technologies in Medicine written by Mark A. Anastasio and published by CRC Press. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the discovery of x-rays in 1895 through the emergence of computed tomography (CT) in the 1970s and magnetic resonance imaging (MRI) in the 1980s, non-invasive imaging has revolutionized the practice of medicine. While these technologies have thoroughly penetrated clinical practice, scientists continue to develop novel approaches that promise to push imaging into entirely new clinical realms, while addressing the issues of dose, sensitivity, or specificity that limit existing imaging approaches. Emerging Imaging Technologies in Medicine surveys a number of emerging technologies that have the promise to find routine clinical use in the near- (less than five years), mid- (five to ten years) and long-term (more than ten years) time frames. Each chapter provides a detailed discussion of the associated physics and technology, and addresses improvements in terms of dose, sensitivity, and specificity, which are limitations of current imaging approaches. In particular, the book focuses on modalities with clinical potential rather than those likely to have an impact mainly in preclinical animal imaging. The last ten years have been a period of fervent creativity and progress in imaging technology, with improvements in computational power, nanofabrication, and laser and detector technology leading to major new developments in phase-contrast imaging, photoacoustic imaging, and optical imaging.
Download or read book Time Resolved Optical Tomography for the Detection and Specification of Breast Disease written by and published by . This book was released on 2005 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Optical Instrumentation and Laser Assisted Biotechnology written by A.M. Verga Scheggi and published by Springer Science & Business Media. This book was released on 1996-08-31 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Study Institute "Biomedical Optical Instrumentation and Laser Assisted Biotechnology" was held November 10-22, 1995 in Erice, Sicily. This was the 19 th conference organized by the International School of Quantum Electronics, under the auspices of the "Ettore Majorana" Center for Scientific Culture. The contributions presented at the Institute are written as extended, review-like papers to provide a broad and representative coverage of the fields of laser techniques, optoelectronics systems for medical diagnosis, and light and laser applications to Biology and Medicine. The aim of the Institute was to bring together some of the world's acknowledged scientists and clinicians that belong to different disciplines and consequently do not usually meet, but who have as a common link the use of optoelectronics instrumentation, techniques and procedures. Most of the lecturers attended all the lectures and devoted their spare hours to stimulating discussions. We would like to thank them all for their admirable contributions. The Institute also took advantage of a very active audience; most of the participants were active researchers in the field and contributed with discussions and seminars. Some of these seminars are also included in these Proceedings. The Institute was an important opportunity to discuss latest developments and emerging perspectives on the use of laser sources and optoelectronic techniques for diagnostic and therapeutic purposes.
Download or read book Breast Tomosynthesis E Book written by Liane E Philpotts and published by Elsevier Health Sciences. This book was released on 2016-11-02 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of tomosynthesis in breast imaging is growing rapidly due to its superior ability to identify and characterize normal findings, benign lesions, and breast cancer, as well as its optimal performance with dense breast tissue. Providing unparalleled coverage of this breakthrough breast imaging modality, Breast Tomosynthesis explains how this new modality can lead to enhanced interpretation and better patient outcomes. This new reference is an indispensable guide for today's practitioner looking to keep abreast of the latest developments with correlative findings, practical interpretation tips, physics, and information on how tomosynthesis differs from conventional 2D FFDM mammography. Over 900 high-quality images offer visual guidance to effectively reading and interpreting this key imaging modality. - Includes over 900 high-quality tomosynthesis and mammography images representing the spectrum of breast imaging. - Features the latest Breast Imaging Reporting and Data System (or BI-RADS) standards updated in February 2014. - Highlights practical tips to interpreting this new modality and how it differs from 2D mammography. - Details how integration of tomosynthesis drastically changes lesion work-up and overall workflow in the department. - "Tomo Tips" boxes offer tips and pitfalls for expert clinical guidance.
Download or read book Photoacoustic Imaging and Spectroscopy written by Lihong V. Wang and published by CRC Press. This book was released on 2017-12-19 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.
Download or read book Oxygen Transport to Tissue XVI written by Michael C. Hogan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception in 1973, The International Society on Oxygen Transport to Tissue (ISOTT) has provided a unique forum to facilitate and encourage scientific interaction and debate. Welcoming scientists and clinicians from a broad spectrum of disciplines, each with their own particular skills and expertise, ISOTT unites them under the common theme of oxygen transport. The successful blend of scientific presentations and informal discussion which characterizes ISOTT is epitomized best by the many fundamental discoveries and technical advancements which it has spawned. The breadth and strengths of The Society's scientific base promotes the rapid progression of ideas from theoretical concepts to rigorous scientific testing and often, ultimately to the clinical arena. Each publication of the ISOTT proceedings has been recognized by Science Citation Index listing and the papers frequently establish scientific precedents and become considered as standard works in their respective fields. The 21st ISOTT Meeting was held in San Diego from August 14th through August 18th, 1993. The San Diego Meeting attracted about 150 registrants and 40 accompanying persons. Ten state-of-the-art lectures were presented by international experts in ~ transport and there were in addition two symposia -one dealing with assessment of tissue hypoxia and the other with functional heterogeneity in different organ systems. There were 100 free communications, consisting of posters accompanied by an abbreviated oral summary. All manuscripts were reviewed by the Editors for form and content, but as is customary for the ISOTT proceedings, rigorous scientific peer review was not undertaken.
