Download or read book Therapeutic Potential of Melatonin written by Georges J. M. Maestroni and published by Karger Medical and Scientific Publishers. This book was released on 1997-01-01 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, the potential of the pineal hormone melatonin as a therapeutic agent in a variety of diseases has been recognized. This book is the first to review the effect of melatonin in sleep disorders, its possible use as an immunoregulatory agent and clinical results obtained in cancer immunotherapy. Several papers are devoted to the pharmacological and molecular characterization of melatonin receptors in a variety of cell types. Other contributions further investigate the immunoenhancing effect of melatonin, such as in viral encephalitis and bacterial infections, and consider possible therapeutic indications. Melatonin is also reported to exert important hematopoietic effects by stimulating the production of novel T helper cell opioid cytokines. Other basic studies introduce new perspectives describing melatonin as a potent free radical scavenger. This book should be read by clinicians working in the fields of sleep disorders, oncology and infectious diseases as well as by scientists active in the field of neuroimmunomodulation. It will also be very useful to all those interested in melatonin as a therapeutic agent.
Download or read book Melatonin written by and published by BoD – Books on Demand. This book was released on 2020-06-24 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, on the pineal hormone melatonin, is addressed to a wide non-cognizant and cognizant readership. The hormone appears to be involved in sleep onset and other functions associated with the body’s clock, the suprachiasmic nucleus. It is ubiquitous throughout both the animal and plant kingdoms and has a long evolutionary history as a hormone. Melatonin has a major role in the regulation of circadian rhythms in non-mammalian vertebrates and forms part of their control in mammals. The present text emphasizes the positive role of exogenously administered melatonin, and its synthetic derivatives, on disrupted circadian rhythm-related dysfunctions. This is effected by resetting the clock in jet lag sufferers and those with seasonal affective disorders, insomnia, and various neurological conditions.
Download or read book Melatonin written by Venkatramanujan Srinivasan and published by CRC Press. This book was released on 2014-10-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.
Download or read book Melatonin written by Venkatramanujan Srinivasan and published by CRC Press. This book was released on 2014-10-15 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin's neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerati
Download or read book The Pineal Gland and Cancer written by C. Bartsch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 979 pages. Available in PDF, EPUB and Kindle. Book excerpt: The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.
Download or read book Melatonin for treatment of sleep disorders written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Melatonin Neuroprotective Agents and Antidepressant Therapy written by Francisco López-Muñoz and published by Springer. This book was released on 2016-11-16 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .
Download or read book Melatonin written by Cristina Manuela Drăgoi and published by BoD – Books on Demand. This book was released on 2018-11-21 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.
Download or read book The Pineal Gland written by I. Nir and published by . This book was released on 2015-01-07 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Melatonin and the Mammalian Pineal Gland written by Josephine Arendt and published by Springer Science & Business Media. This book was released on 1994-12-31 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the reader with an overview of an intriguing and interdisciplinary field of research. For the first time the mammalian pineal gland, its mode of action and its physiological effects are discussed in a comprehensive, single-authored work.
Download or read book Psychiatry and Neuroscience Update written by Pascual Ángel Gargiulo and published by Springer. This book was released on 2018-12-11 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This broad and thought-provoking volume provides an overview of recent intellectual and scientific advances that bridge the gap between psychiatry and neuroscience, offering a wide range of penetrating insights in both disciplines. The third volume on the topic in the last several years from a varying panel of international experts, this title identifies the borders, trends and implications in both fields today and goes beyond that into related disciplines to seek out connections and influences. Similar to its two Update book predecessors, Psychiatry and Neuroscience – Volume III presents the current state-of-the-art in the main disciplines – psychiatry and neuroscience – and attempts to provide deeper comprehension or explication of the normal and diseased human mind, its biological correlates and its biographical and existential implications. This engaging volume continues the previous style of exploring different disciplines and trying to integrate disciplinary evidence from varying points of view in an organic manner. Developed for clinicians and researchers in the fields of medicine, psychiatry, psychology and biology, this third volume also will be of great interest to students and university professors of diverse disciplines.
Download or read book Salivary Glands written by Işıl Adadan Güvenç and published by BoD – Books on Demand. This book was released on 2019-01-30 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Saliva is a complex fluid that maintains oral health and has many physiological functions. It is a noninvasive diagnostic fluid as well. Lately, salivary diagnostics has proven its potential to reach clinical practice in the near future for the early detection, diagnosis, and monitoring of various diseases. Salivary Glands - New Approaches in Diagnostics and Treatment is a comprehensive reference, which brings together information on salivary secretion and its disorders, the novel salivary diagnostic methods for numerous diseases, and new techniques in the treatment of salivary diseases. This book contains information for a diverse audience, including dentists, oral biologists, experimental biologists, molecular biologists, oncologists, radiologists, oral and maxillofacial surgeons, and otorhinolaryngologists.
Download or read book The Pineal Gland and Its Hormones written by Franco Fraschini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the written contributions to the proceedings of a workshop related to the pineal gland and its hormones, which was held in Erice, Italy, on June 7 -June 13, 1994. This series of workshops, which began in 1982 and which have been held at four-year intervals since that time, has provided important continuity for advancing the state of knowledge relating to this very important investigative area. The enthusiasm for these conferences has increased steadily, as reflected in the number of individuals applying to attend and in the input of individuals who participate in the meeting. The 1994 meeting was important because of its timeliness. In the two years preceding the meeting a number of revolutionary discoveries were made relative to the actions of the pineal hormone melatonin. The Xenopus melatonin receptor was cloned, melatonin was demonstrated to be a potent antioxidant, the significance of melatonin receptors at the level of pars tuberalis in the regulation of the hypothalamo-pituitary-gonadal axis was questioned, a number of melatonin receptor analogues were discovered and successfully utilized, the mechanisms by which melatonin retards initiation and promotion of cancer was further elucidated, the clinical aspects of the pineal gland was re-scrutinized. Reviews relating to each of these subjects, as well as many others, are contained in this proceedings book. This volume represents an up-to-date repository for the most recent information related to this rapidly advancing field.
Download or read book Diabetes and Its Complications written by Ahmed R. G. and published by BoD – Books on Demand. This book was released on 2018-04-18 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a complex, progressive disease, which is accompanied by several complications. It is listed among the most common endocrine disorders and a global metabolic epidemic disease. This book focuses on the recent progress in diabetes research worldwide. It has been written by extensively acknowledged experts, with each chapter providing a unique data on developing features of diabetes. It covers the interactions between diabetes and several disorders. Also, it suggests some treatments for this disease offering us hope in prevention and successful improvement.
Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Download or read book Melatonin in the Promotion of Health Second Edition written by Ronald Ross Watson and published by CRC Press. This book was released on 2011-08-25 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including: Gut motility and gastrointestinal diseases Anesthesia and surgery Bone health Breast cancer Cardiovascular diseases Diabetes Age-related macular degeneration and uveitis Melanoma, solar skin damage, and collagen synthesis The prevention of DNA damage Mental disorders, sleep, and issues related to jet lag and shift work The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities, making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.
