Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Download or read book WHO Laboratory Manual for the Examination of Human Semen and Sperm Cervical Mucus Interaction written by World Health Organisation and published by Cambridge University Press. This book was released on 1999-05-13 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive and essential source of reference for all laboratories involved in the analysis of human semen.
Download or read book Human Chromosomes written by Orlando J. Miller and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.
Download or read book Adam s Curse written by Bryan Sykes and published by W. W. Norton & Company. This book was released on 2004 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the history and future of the Y chromosome and maintains that because it is unable to exchange genetic material or repair itself, the day will come when it will cease to exist.
Download or read book Principles of Developmental Genetics written by Sally A. Moody and published by Elsevier. This book was released on 2007-07-19 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models
Download or read book The Y Chromosome written by Leona Gom and published by Cormorant Books. This book was released on 2019-05-11 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Y Chromosome challenges the reader to meet an all-woman society of the future. The few remaining men live in hiding. When one of these men is discovered, the resulting conflict threatens both worlds. The futurist society was developed by necessity and is far from perfect, but it now abhors its male-dominated past, where violence escalated to an extreme. The journals of a man who lived during The Change reveal the desperate turmoil and anger of a world facing the extinction of half its members. The journals are now part of university history courses, leading to assessments of the past that are both ironic and disturbing. Despite its striking differences to our world today, there are uncomfortable similarities. Taut and gripping, a page turner at its very best, the novel asks important and fundamental questions about who we are as women and men and what we will do to survive. Originally written and published thirty years ago to enthusiastic reviews, The Y Chromosome is even more relevant today.
Download or read book Sex Itself written by Sarah S. Richardson and published by University of Chicago Press. This book was released on 2013-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human genomes are 99.9 percent identical—with one prominent exception. Instead of a matching pair of X chromosomes, men carry a single X, coupled with a tiny chromosome called the Y. Tracking the emergence of a new and distinctive way of thinking about sex represented by the unalterable, simple, and visually compelling binary of the X and Y chromosomes, Sex Itself examines the interaction between cultural gender norms and genetic theories of sex from the beginning of the twentieth century to the present, postgenomic age. Using methods from history, philosophy, and gender studies of science, Sarah S. Richardson uncovers how gender has helped to shape the research practices, questions asked, theories and models, and descriptive language used in sex chromosome research. From the earliest theories of chromosomal sex determination, to the mid-century hypothesis of the aggressive XYY supermale, to the debate about Y chromosome degeneration, to the recent claim that male and female genomes are more different than those of humans and chimpanzees, Richardson shows how cultural gender conceptions influence the genetic science of sex. Richardson shows how sexual science of the past continues to resonate, in ways both subtle and explicit, in contemporary research on the genetics of sex and gender. With the completion of the Human Genome Project, genes and chromosomes are moving to the center of the biology of sex. Sex Itself offers a compelling argument for the importance of ongoing critical dialogue on how cultural conceptions of gender operate within the science of sex.
Download or read book Y written by Steve Jones and published by Houghton Mifflin Harcourt. This book was released on 2003 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents
Download or read book Advanced Topics in Forensic DNA Typing Interpretation written by John M. Butler and published by Academic Press. This book was released on 2014-07-28 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. - Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence - Worked mixture examples illustrate the impact of different statistical approaches for reporting results - Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011
Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
Download or read book The X in Sex written by David. BAINBRIDGE and published by Harvard University Press. This book was released on 2009-06-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: A tiny scrap of genetic information determines our sex; it also consigns many of us to a life of disease, directs or disrupts the everyday working of our bodies, and forces women to live as genetic chimeras. The culprit--so necessary and yet the source of such upheaval--is the X chromosome, and this is its story. An enlightening and entertaining tour of the cultural and natural history of this intriguing member of the genome, The X in Sex traces the journey toward our current understanding of the nature of X. From its chance discovery in the nineteenth century to the promise and implications of ongoing research, David Bainbridge shows how the X evolved and where it and its counterpart Y are going, how it helps assign developing human babies their sex--and maybe even their sexuality--and how it affects our lives in infinitely complex and subtle ways. X offers cures for disease, challenges our cultural, ethical, and scientific assumptions about maleness and femaleness, and has even reshaped our views of human evolution and human nature. Table of Contents: Prologue 1. Making a Difference Interlude: What Is It, Exactly? 2. The Duke of Kent's Testicles Interlude: How Sexy Is X? 3. The Double Life of Women Epilogue: The Chosen One Further Reading Glossary Index Reviews of this book: The author of Making Babies takes a lively, witty tour of the X chromosome, creator of "a delicious symmetry between men and women"...Entertaining and informative...A fine demonstration of science made accessible. --Kirkus Reviews Reviews of this book: A well-written, well-researched, easy-to-read study that explains what has been learned about the X and Y chromosomes using DNA sequencing and other molecular biology techniques. British biologist Bainbridge...has pulled together historical and current scientific research about how the X and Y chromosomes affect us and what the genes on these chromosomes actually do, like causing sex-linked diseases and color blindness...An excellent example of good science writing...Recommended. --Margaret Henderson, Library Journal Reviews of this book: Bainbridge is an essentialist, interested in understanding what aspects of gender are biologically driven, and why...He has a central question he wants to answer. The question is not so much why men and women are different (a worn topic that's the subject of too many Mars-and-Venus bestsellers) but, far more specific and far more interesting: Why are men and women more different than they need to be? --Liza Mundy, Washington Post Reviews of this book: Bainbridge summarizes our knowledge of the genetic information that determines one's sex by recounting the ancients' speculations about the genesis of gender, following with modern biologists' discovery of the X and Y chromosomes about a century ago, and of the sex-determining gene Sry in the 1990s. In a discussion rich with history, evolution, and philosophy, Bainbridge points out the dramatic effect that gender selection has on people's lives...A fascinating, often humorous analysis of the science of sexuality. --Gilbert Taylor, Booklist Reviews of this book: In The X in Sex, David Bainbridge explains the far-reaching effects of X. Bainbridge...moves with ease between straightforward accounts of biology and historical stories about its effect, like the chapter describing the progression of hemophilia through the royal houses of Europe. Bainbridge discusses cultural history as well as natural history, and his wit enlivens every page. --Christine Kenneally, New York Times Book Review Reviews of this book: There are many literary stars (such as Stephen Jay Gould, Richard Dawkins and Matt Ridley) in the firmament of writers on evolution, and to a man they write with dash and persuasive logic. David Bainbridge is one such and in his latest book he takes the reader through the glories of the X chromosome at a cracking pace. --Miriam Stoppard, Times Higher Education Supplement (UK) Reviews of this book: The truth is that the behaviours of [chromosomes] X and Y are inextricably linked. Bainbridge explores this link in a compelling tale that takes in how the sex chromosomes became sex chromosomes, and the very different consequences of this for women and men. Along the way we encounter the Duke of Kent's testicles, calico cats and non-identical identical twin girls. His story weaves science, history and the history of science (with a little religion for good measure) in a straightforward, anecdotal fashion that will appeal to scientists and non-scientists alike. --Mark T. Ross, New Scientist (UK) Reviews of this book: In his structure/function analysis of the X chromosome, Bainbridge provides a tongue-in-cheek, yet informative, description of one of the two human sex chromosomes. --R. Adler, Choice Reviews of this book: If you have ever been intrigued by some of the puzzles of genetics--why boys tend to get haemophilia or colour blindness while girls are more likely to have an identical twin or to develop rheumatoid arthritis later in life--then The X in Sex is for you. --Chris Tyler-Smith, Times Literary Supplement David Bainbridge takes us on a fascinating tour of X chromosomes and explains what the possession of these intricately folded, infinitessimally narrow, two-inch long strings of genetic codes weighing almost nothing, means for their bearers--that is for each one of us, male and female. History and personal anecdotes are woven together with up-to-date summaries of the science, punctuated with Bainbridge's zany--and very British--humor, so that this information-packed book is pure pleasure to read. --Sarah Blaffer Hrdy author of Mother Nature: A History of Mothers, Infants, and Natural Selection The X in Sex is absolutely fascinating, so intriguing, in fact, that I found myself unwilling to put it down. David Bainbridge surveys an astonishing amount of new information from recent genomic studies of the X chromosome, clearly explaining the findings in a way the average person can easily follow. The science is presented via amusing and highly appropriate metaphors and clever turns of phrase, all of which serve to brighten the prose and present the reader with catchy ways to think about complex ideas. This is an informative, authoritative, and thoroughly enjoyable read: one of the best books I have read in recent years. --Jane Lancaster, University of New Mexico This is wonderful stuff--beautifully written, clear, jargon-free, with anecdotes sure to hold the attention. --other hupauthorTim Birkhead, author of Promiscuity: An Evolutionary History of Sperm Competition
Download or read book Sex Chromosomes and Sex Linked Genes written by Susumu Ohno and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural selection operates among individual organisms which differ in their genetic constitution. The degree of hereditary variability within a species is greatly enhanced by cross-fertilization. Indeed, the mechanism of sexual reproduction occurred very early in evolution, for it is seen today even in bacteria. In Escherichia coli, fertilization occurs by passage of the single chromosome from the male into the female bacterium (LEDERBERG, 1959). In multicellular organisms, the separation of germ from soma, and the production of haploid gametes became mandatory. The gametes were of two types. One, extremely mobile, was designed to seek out and penetrate the other, which loaded with nutrients, received the mobile gamete and intiated the development of a new individual. The foundation for true bisexuality was thus laid. In the primitive state of bisexuality, whether an individual is to be a sperm-producing male or an egg-producing female appears to be decided rather haphazardly. In the worm, Banelia viridis, the minute males are parasites in the female. Larvae that become attached to the proboscis of an adult female become males, while unattached larvae sink to the bottom and become females (BALTZER, 1935). The more sophisticated state of bisexuality was initiated by setting aside a particular pair of chromosomes for specialization and making either the male or the female a heterogametic sex. Sex chromosomes as we know them were thus born.
Download or read book The Y Chromosome And Male Germ Cell Biology In Health And Diseases written by Chris Yun-fai Lau and published by World Scientific. This book was released on 2007-04-16 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completion of the human genome and technological advances developed by the Human Genome Project have dramatically changed our understanding of the mechanisms underlying the development and differentiation of male germ cells, and our ability to investigate such mechanisms. This book is a timely document of advances made in the field of male gonad and germ cell research in the postgenomic era.The coverage includes the role of Y chromosome genes in male reproduction, gene expression in spermatogonial stem cells and male germ cells, and the regulation of germ cell genes in reproduction and in germ cell tumors.
Download or read book The Better Half written by Dr. Sharon Moalem, MD, PhD and published by Farrar, Straus and Giroux. This book was released on 2020-04-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Guardian Book of the Week Longlisted for the PEN / E. O. Wilson Literary Science Writing Award An award-winning physician and scientist makes the game-changing case that genetic females are stronger than males at every stage of life Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colors. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behavior of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.
Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. - Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism - Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics - Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Download or read book Evolution of the Human Genome II written by Naruya Saitou and published by Springer. This book was released on 2022-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing “Non-neutral Evolution on Human Genes” (Part I) and “Evolution of Modern Human Populations” (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety of populations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.
Download or read book The Genetic Basis of Male Infertility written by Ken McElreavey and published by Springer Science & Business Media. This book was released on 2000 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.
