Download or read book The use of next generation sequencing for the surveillance of drug resistant tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2023-10-17 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document provides practical guidance on planning and implementing next-generation sequencing (NGS) technology for the characterization of Mycobacterium tuberculosis complex (MTBC) bacteria. The aim is to detect mutations associated with drug resistance in the context of a surveillance system for tuberculosis (TB). This guide is intended to inform staff of national TB programmes and ministries of health, implementing partners, laboratory managers and technical staff, clinicians, donors, and other stakeholders engaged in the surveillance of drug-resistant TB and TB laboratory strengthening.
Download or read book Laboratory Methods for Clinical and Public Health written by George P. Kubica and published by . This book was released on 1967 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book WHO consolidated guidelines on drug resistant tuberculosis treatment written by World Health Organization and published by World Health Organization. This book was released on 2018-11-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult to treat than drug-susceptible ones, and threaten global progress towards the targets set by the End TB Strategy of the World Health Organization (WHO). There is thus a critical need for evidence-based policy recommendations on the treatment and care of patients with DR-TB, based on the most recent and comprehensive evidence available. In this regard, the WHO consolidated guidelines on drug-resistant tuberculosis treatment fulfil the mandate of WHO to inform health professionals in Member States on how to improve treatment and care for patients with DR-TB. Between 2011 and 2018, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO treatment guidelines for multidrug- and rifampicin-resistant tuberculosis, 2018 update, issued by WHO in December 2018. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups (GDGs), using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present Consolidated guidelines include a comprehensive set of WHO recommendations for the treatment and care of DR-TB, derived from these WHO guidelines documents. The consolidated guidelines include policy recommendations on treatment regimens for isoniazid-resistant TB (Hr-TB) and MDR/RR-TB, including longer and shorter regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care.
Download or read book The Use of Bedaquiline in the Treatment of Multidrug resistant Tuberculosis written by World Health Organization and published by . This book was released on 2015-04-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO estimates that up to half a million new cases of multidrug-resistant tuberculosis (MDR-TB) occur worldwide, each year. Current treatment regimens for MDR-TB present many challenges: treatment lasts 20 months or more, requiring daily administration of drugs that are more toxic, less effective, and far more expensive than those used to treat drug-susceptible TB. Globally, less than half of all patients who start MDR-TB therapy are treated successfully. For the first time in over 40 years, a new TB drug with a novel mechanism of action - bedaquiline- is available, and was granted accelerated approval by the United States Food and Drug Administration in December 2012. There is considerable interest in the potential of this drug to treat MDR-TB. However, information about this new drug remains limited. It has only been through two Phase IIb trials for safety and efficacy. The World Health Organization (WHO) is therefore issuing "interim policy guidance". This interim guidance provides advice on the inclusion of bedaquiline in the combination therapy of MDR-TB in accordance with the existing WHO Guidelines for the Programmatic Management of Drug-resistant TB (2011 Update).
Download or read book WHO operational handbook on tuberculosis Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2024-03-15 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest edition replacing the one issued in 2021. A new class of technologies for drug susceptibility testing is endorsed by WHO and included in this edition: targeted next generation sequencing. The operational handbook aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB. It provides practical information on existing and new tests recommended by WHO, step-by-step advice on implementing and scale-up testing to achieve local and national impact and lastly, model diagnostic algorithms, which are updated to incorporate the latest recommendations. An overview of budgetary considerations and information sheets on each of the newly recommended tests is provided. The class of targeted next generation sequencing is recommended for the detection of resistance to a number of first- and second-line anti-TB drugs, rather than culture-based phenotypic drug susceptibility testing. The recommendations will open for faster detection of resistance to a range of anti-TB drugs directly from sputum samples.
Download or read book WHO consolidated guidelines on tuberculosis Module 4 written by World Health Organization and published by World Health Organization. This book was released on 2022-04-30 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 2011 and 2019, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment includes a comprehensive set of WHO recommendations for the treatment and care of DR-TB. The document includes two new recommendations, one on the composition of shorter regimens and one on the use of the BPaL regimen (i.e. bedaquiline, pretomanid and linezolid). In addition, the consolidated guidelines include existing recommendations on treatment regimens for isoniazid-resistant TB and MDR/RR-TB, including longer regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), the use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care. The guidelines are to be used primarily in national TB programmes, or their equivalents in Ministries of Health, and for other policy-makers and technical organizations working on TB and infectious diseases in public and private sectors and in the community.
Download or read book Management of MDR TB written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are increasingly encountered in resource-limited settings. In the context of a national response to MDR- and XDR-TB, health workers in TB clinics (in district hospitals and some accredited health centers) will need to diagnose MDR-TB, initiate second-line anti-TB drugs, and monitor MDR-TB treatment. This Field Guide was created to help health workers carry out these tasks. It is a job aid that medical officers and TB nurses are meant to use frequently during the day for quick reference. It is based on the Emergency Update 2008 of Guidelines for Programmatic Management of Drug-resistant Tuberculosis, and may be considered a companion document to these guidelines. It also draws on the experience of the international health NGO Partners In Health (PIH) in many countries. This module should be introduced to health workers in the context of a training course with a strong emphasis on TB-HIV co-management.
Download or read book Guidelines for the Programmatic Management of Drug Resistant Tuberculosis written by World Health Organization and published by . This book was released on 2015-04-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2011 update of Guidelines for the programmatic management of drug-resistant tuberculosis is intended as a tool for use by public health professionals working in response to the Sixty-second World Health Assembly's resolution on prevention and control of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Resolution WHA62.15, adopted in 2009, calls on Member States to develop a comprehensive framework for the management and care of patients with drug-resistant TB. The recommendations contained in these guidelines address the most topical questions concerning the programmatic management of drug-resistant TB: case-finding, multidrug resistance, treatment regimens, monitoring the response to treatment, and selecting models of care. The guidelines primarily target staff and medical practitioners working in TB treatment and control, and partners and organizations providing technical and financial support for care of drug-resistant TB in settings where resources are limited.
Download or read book Essential Tuberculosis written by Giovanni Battista Migliori and published by Springer Nature. This book was released on 2021-07-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.
Download or read book Guidance for the surveillance of drug resistance in tuberculosis sixth edition written by and published by World Health Organization. This book was released on 2021-02-12 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this document is to assist national TB programmes in developing the strongest possible mechanisms of surveillance, starting from periodic country-specific surveys of sampled patients. The ultimate goal is to establish continuous surveillance systems based on routine drug susceptibility testing (DST). This guidance promotes certain standardized criteria for surveillance to ensure that results are comparable within and between countries over time. The target audience of this document is national TB programmes and, in particular, the coordination team for surveillance ideally composed of the programme manager, a laboratory specialist, a logistician, and an epidemiologist/statistician.
Download or read book The use of next generation sequencing in fighting antimicrobial resistant pathogens written by Ibrahim Bitar and published by Frontiers Media SA. This book was released on 2023-03-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Application of Next Generation Sequencing NGS in Infection Prevention written by Michael Kemp and published by Frontiers Media SA. This book was released on 2022-07-04 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Global Tuberculosis Report 2018 written by World Health Organization and published by World Health Organization. This book was released on 2018-11-20 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic and of progress in prevention diagnosis and treatment of the disease at global regional and country levels. This is done in the context of recommended global TB strategies and targets endorsed by WHO?s Member States and broader development goals set by the United Nations (UN). The 2018 edition of the global TB report was released on 18 September in the lead up to the first-ever UN High Level Meeting on TB on 26 September 2018.
Download or read book Integration of NGS in clinical and public health microbiology workflows applications compliance quality considerations written by Varvara K. Kozyreva and published by Frontiers Media SA. This book was released on 2024-02-05 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expansion of NGS implementation in clinical and public health practice accelerated drastically during the SARS-CoV-2 pandemic, where NGS has been playing a vital role in tracking dangerous strains of the virus. NGS applications not only influenced public health decision-making but also have been crossing into the clinical field with individual patients’ results being potentially available to the physicians. Hence, the topic of implementation of NGS methods in clinical and public health microbiology, its challenges and special considerations, is as timely as ever. The use of Next Generation Sequencing (NGS) in clinical and public health microbiology laboratories has been steadily expanding in the past decade. However, this progress has been held back by multiple logistical challenges, like the absence of regulatory compliance framework, lack of clear quality guidelines, the need for standardization and interoperability between laboratories, as well as cost and turn-around-time limitations.
Download or read book Evidence and research gaps identified during development of policy guidelines for tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2024-01-22 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Achieving the goals and targets of the WHO End TB Strategy requires innovative tools and strategies as well as rapid progress towards universal access. This document serves as an update to a previously released report with an identical title: It summarizes evidence gaps articulated in various WHO TB policy guidance to help steer innovation towards sustainable, desirable, acceptable, and feasible public health interventions required to end TB. It aims to serve as a reference for research policy-makers, funders, civil society and other relevant actors on the urgent TB research priorities for policy guidance.
Download or read book Molecular Microbiology written by David H. Persing and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Download or read book Tuberculosis An Issue of Clinics in Chest Medicine written by Charles Daley and published by Elsevier Health Sciences. This book was released on 2019-11-21 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Chest Medicine, edited by Dr. Charles L. Daley and Dr. David Lewinsohn, focuses on Tuberculosis. Topics include: Epidemiology of Tuberculosis (TB) in the United States; Immunology of Tuberculosis; Tuberculosis and Biologics; Laboratory Diagnosis of Tuberculosis; Supranational Tuberculosis Reference Laboratories (a global approach); Treatment of Drug Susceptible Tuberculosis; Treatment of Drug-Resistant Tuberculosis; New Drugs for the Treatment of Tuberculosis; Diagnosis of Latent Tuberculosis: the Role of Interferon Gamma Release; Treatment of Latent Tuberculosis; Management of Children with Tuberculosis; Tuberculosis and HIV; The Future of Vaccines for Tuberculosis; and Preventing Transmission of M. Tuberculosis.
