Download or read book The Unblinding written by Laurence Lieberman and published by New York : Macmillan. This book was released on 1968 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Unblinded written by Traci Medford-Rosow and published by Morgan James Publishing. This book was released on 2018-04-24 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: The USA Today–bestselling biography of a man who lost his sight as an adult and regained it twenty years later without any medical intervention. Unblinded is the true story of New Yorker Kevin Coughlin, who became blind at age thirty-six due to a rare genetic disorder known as Leber’s Hereditary Optic Neuropathy. Twenty years later, without medical intervention, Kevin’s sight miraculously started to return. He is the only known person in the world who has experienced a spontaneous, non-medically assisted, regeneration of the optic nerve. Unblinded follows Kevin’s descent into darkness, and his unexplained reemergence to sight. Praise for Unblinded “A remarkable story of sudden blindness, new vision, and sight regained. It offers great insight into the nature of reality—that which we perceive and that which we create for ourselves.”—Isaac Lidsky, New York Times–bestselling author of Eyes Wide Open “Its pages take us, at once, on a remarkable true adventure and into the heart and mind of a most extraordinary individual. A beautifully written and inspiring tale, and a reminder to us all about what really matters.”—Robert Kurson, New York Times–bestselling author of Rocket Men “Unblinded provides honest, profound insight into the emotional trauma that occurs when vision is lost and the path forward in life cannot be seen.”—Lissa Poincenot, National Leber’s Hereditary Optic Neuropathy Advocate “A fascinating, behind-the-scenes tour of what went on during those years of darkness and how Kevin Coughlin, after battling alcoholism, loneliness, prejudice, and perhaps most of all himself, emerges as a man of wisdom and sight.”—Ann Campanella, award-winning and bestselling author of Motherhood: Lost and Found
Download or read book Good Research Practice in Non Clinical Pharmacology and Biomedicine written by Anton Bespalov and published by Springer Nature. This book was released on 2020-01-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Download or read book Planning Clinical Research written by Robert A. Parker and published by Cambridge University Press. This book was released on 2016-10-12 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by . This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.
Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Download or read book Financial Cryptography written by Matt Blaze and published by Springer Science & Business Media. This book was released on 2007-07-21 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth International Financial Cryptography Conference was held during March 11-14, 2002, in Southampton, Bermuda. As is customary at FC, these proceedings represent "final" versions of the papers presented, revised to take into account comments and discussions from the conference. Submissions to the conference were strong, with 74 papers submitted and 19 accepted for presentation and publication. (Regrettably, three of the submit ted papers had to be summarily rejected after it was discovered that they had been improperly submitted in parallel to other conferences.) The small program committee worked very hard under a tight schedule (working through Christmas day) to select the program. No program chair could ask for a better committee; my thanks to everyone for their hard work and dedication. In addition to the refereed papers, the program included a welcome from the Minister of Telecommunications and e-Commerce, Renee Webb, a keynote address by Nigel Hickson, and a panel on privacy tradeoffs cheiired by Rebecca Wright (with panelists Ian Goldberg, Ron Rivest, and Graham Wood). The traditional Tuesday evening "rump session" was skillfully officiated by Markus Jakobsson. My job as program chair was made much, much easier by the excellent work of our general chair, Nicko van Someren, who performed the miracle of hiding from me any evidence of the innumerable logistical nightmares associated with conducting this conference. I have no idea how he did it, but it must have involved many sleepless nights.
Download or read book Information Security written by Liqun Chen and published by Springer. This book was released on 2018-09-03 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the proceedings of the 21st International Conference on Information Security, ISC 2018, held in Guildford, UK, in September 2018. The 26 full papers presented in this volume were carefully reviewed and selected from 59 submissions. The book also includes one invited talk in full-paper length. The papers were organized in topical sections named: software security; symmetric ciphers and cryptanalysis; data privacy and anonymization; outsourcing and assisted computing; advanced encryption; privacy-preserving applications; advanced signatures; and network security.
Download or read book Practical Guide to Clinical Data Management written by Susanne Prokscha and published by CRC Press. This book was released on 2024-07-03 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment. Groundbreaking on its initial publication nearly 14 years ago, and evolving with the field in each iteration since then, this latest volume includes revisions to all chapters to reflect the recent updates to ICH E6, good clinical practices, electronic data capture, and interactive response technologies. Keeping the coverage practical, the author focuses on the most critical information that impacts clinical trial conduct, providing a full end-to-end overview for clinical data managers. Features: Provides an introduction and background information for the spectrum of clinical data management tasks. Outstanding text in the industry and has been used by the Society for Clinical Data Management in creating its certification exam. Explains the high-level flow of a clinical trial from creation of the protocol through study lock. Reflects electronic data capture and interactive response technologies. Discusses using the concept of three phases in the clinical data management of a study: study startup, study conduct, and study closeout, to write procedures and train staff.
Download or read book Ghosts of molecules The case of the memory of water written by Francis BEAUVAIS and published by Lulu.com. This book was released on 2015-08-03 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of a scientific controversy: the case of "memory of water". A true scientific thriller with detailed descriptions of disputed experiments performed by the French immunologist Jacques Benveniste; with many details of the famous conflict with the scientific journal Nature and its Director John Maddox. www.mille-mondes.fr
Download or read book Eight Preposterous Propositions written by Robert Ehrlich and published by Princeton University Press. This book was released on 2021-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placebo cures. Global warming. Extraterrestrial life. Psychokinesis. In a time when scientific claims can sound as strange as science fiction--and can have a profound effect on individual life or public policy--assessing the merits of a far-out, supposedly scientific idea can be as difficult as it is urgent. Into the breach between helpless gullibility and unyielding skepticism steps physicist Robert Ehrlich, with an indispensable guide to making sense of "scientific" claims. A series of case studies of some of the most controversial (and for the judging public, deeply vexing) topics in the natural and social sciences, Ehrlich's book serves as a primer for evaluating the evidence for the sort of strange-sounding ideas that can shape our lives. A much-anticipated follow-up to his popular Nine Crazy Ideas in Science, this book takes up issues close to readers' everyday reality--issues such as global warming, the dangers of cholesterol, and the effectiveness of placebos--as well as questions that resonate through (and beyond) civic life: Is intelligent design a scientific alternative to evolution? Is homosexuality primarily innate? Are people getting smarter or dumber? In each case, Ehrlich shows readers how to use the tools of science to judge the accuracy of strange ideas and the trustworthiness of ubiquitous "experts." As entertaining as it is instructive, his book will make the work of living wisely a bit easier and more reliable for scientists and nonscientists alike.
Download or read book Cryptology and Network Security written by Mauro Conti and published by Springer Nature. This book was released on 2021-12-08 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 20th International Conference on Cryptology and Network Security, CANS 2021, which was held during December 13-15, 2021. The conference was originally planned to take place in Vienna, Austria, and changed to an online event due to the COVID-19 pandemic. The 25 full and 3 short papers presented in these proceedings were carefully reviewed and selected from 85 submissions. They were organized in topical sections as follows: Encryption; signatures; cryptographic schemes and protocols; attacks and counter-measures; and attestation and verification.
Download or read book Digital Privacy written by Jan Camenisch and published by Springer. This book was released on 2011-04-12 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents the R&D outcome of the PRIME Project, an R&D project partially funded by the European Union’s Sixth Framework Programme and the Swiss Federal Office for Education and Science. PRIME has focused on privacy-enhancing identity management techniques and systems to support users’ sovereignty over their personal privacy and enterprises’ privacy-compliant data processing. During the course of four years, the project has involved over a hundred researchers and professionals from 22 major European academic and industrial organizations conducting R&D work in areas relevant to digital privacy. The book presents 28 detailed chapters organized in five parts: Introductory summary, legal, social, and economic aspects, realization of privacy-enhancing user-centric identity management, exploitation of PRIME results for applications, conclusions drawn and an outlook on future work. As the first coherent presentation of the topic, this book will serve as a valuable source of reference and inspiration for anybody working on digital privacy.
Download or read book Cracking the Quantum Code of the Universe written by John Moffat and published by Oxford University Press. This book was released on 2014-02 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: If the new boson is indeed the Higgs particle, its discovery represents an important milestone in the history of particle physics. However, despite the pressure to award Nobel Prizes to physicists associated with the Higgs boson, John Moffat argues that there still remain important data analyses to be performed before uncorking the champagne. John Moffat is Professor Emeritus of Physics at the University of Toronto and a senior researcher at the Perimeter Institute for Theoretical Physics. Well-known for his outside-the-box research on topics such as dark matter, dark energy, and the varying speed of light cosmology (VSL), his new book takes a critical look at the hype surrounding the Higgs boson. In the process, he presents a cogent and often entertaining history of particle physics and an exploration of alternative theories of particle physics that do not feature the Higgs boson, including his own. He gives a detailed and personal description of how theoretical physicists come up with new theories, and emphasizes how carefully experimental physicists must interpret the complex data now coming out of accelerators like the Large Hadron Collider (LHC). The book does not shy away from controversial topics such as the sociology of particle physics. There is immense pressure on projects like the $9 billion LHC to come up with positive results in order to secure funding for the future. Yet to date, the Higgs boson may be the only positive result to emerge from the LHC experiments. The searches for dark matter particles, mini-black holes, extra dimensions, and supersymmetric particles have all come up empty-handed, with serious consequences for theoretical physics, including string theory and gravity theory. John Moffat is also the author of Reinventing Gravity (2008) and Einstein Wrote Back (2010).
Download or read book Pain written by Chas Bountra and published by CRC Press. This book was released on 2003-05-13 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.
Download or read book Clinical Trial Project Management written by Ashok Kumar Peepliwal and published by Elsevier. This book was released on 2023-11-15 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trial Project Management provides a detailed overview of how to conduct clinical trials, in an international context. The process of conducting clinical studies across nations is based on a set of regulatory regimes developed by respective regulatory agencies. The book focuses on clinical study protocol approval processes, Ethics Committee approval processes, clinical study feasibilities, site selection, site initiation, site monitoring, database lock, sit close-out, clinical data processing and management, SAE reporting and compensation, randomization procedure, pharmacovigilance, statistical tools, BA/BE studies, and clinical study report writing etc. covering entire clinical trial process of conductance. In addition to that the author also incorporated the clinical trial approval process of USFDA, EMA, and JAPAN to conduct the clinical trials. Covers how to conduct clinical trials in detail Present useful, basic, and advanced statistical tools Provides real-time project management methods like Program Evaluation Review Technique (PERT) and Critical Path Method (CPM) to manage complex projects are described in the book
