Download or read book Finding Dr Schatz written by Inge Auerbacher and published by iUniverse. This book was released on 2006-03-09 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: As part of his doctoral research, Albert Schatz, a twenty-three-year-old graduate student at Rutgers University in New Brunswick, New Jersey, diligently worked alone in a basement laboratory to find an antibiotic to treat tuberculosis. In October of 1943, Schatz discovered streptomycin. But his professor, Selman Waksman, took the credit, relegating Schatz to the footnotes of history. Over fifty years later, German-born Inge Auerbacher read an article that named Schatz as co-discoverer of the drug. As a young Jewish girl during World War II, Auerbacher was a prisoner at Terezin concentration camp in Czechoslovakia. She was diagnosed with tuberculosis during her imprisonment and was able to receive the life-saving streptomycin after her immigration to America. Auerbacher contacted Schatz in 1997, compelled to offer him gratitude for the scientific research that saved her life. She learned of the controversy surrounding the discovery of streptomycin and Schatz's ultimate recognition for his work. As a result of their friendship, they decided to co-author this book. Finding Dr. Schatz is their powerful true story-told in their own words-of a scientist who changed the world and a woman who lived because of it.
Download or read book Antibacterial Drugs Today written by A.P. Ball and published by Springer. This book was released on 1979-05-31 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first edition there has been a great demand for this book. It has been revised to include up-to-date and new entries covering recent additions to the availa ble drugs. As well there are now sections on clinical situations, or types of patient, presenting especial problems. The authors hope this new material will enhance the effectiveness of the book as a guide to this rapidly advancing and changing therapeutic situation. A.P.B. J.A.G. J.McC.M. July, 1978 v Contents I. Antibacterial Drugs 1.1 Mechanisms of Action I .2 Side Effects and Toxicity 2 2. The Sulphonamides .............................. . 2 2.1 Antibacterial Activity .... 2 2.2 Mode of Antibacterial Action 2.3 Pharmacology 3 2.4 Therapeutic Indications ... 4 2.5 Dosage ....................... . 4 2.5.1 Short Acting Sulphonamides ..................... . 4 2.5.2 Long Acting Sulphonamides 5 2.5.3 Non-absorbable Sulphonamides 5 2.6 Side Effects and Toxicity 5 2.6.1 Nephrotoxicity ............................... . 5 2.6.2 Haematological Abnormalities 5 2.6.3 Pulmonary Disease .. . 5 2.6.4 Hypersensitivity .................................................. . 6 2.7 Drug Interactions ... 6 3. The Natural Penicillins - Benzylpenicillin (Penicillin G) and Phenoxymetbylpe- cillin (Penicillin V) .......................... . ..................... .
Download or read book Experiment Eleven written by Peter Pringle and published by Bloomsbury Publishing USA. This book was released on 2012-05-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1943, Albert Schatz, a young Rutgers College Ph.D. student, worked on a wartime project in microbiology professor Selman Waksman's lab, searching for an antibiotic to fight infections on the front lines and at home. In his eleventh experiment on a common bacterium found in farmyard soil, Schatz discovered streptomycin, the first effective cure for tuberculosis, one of the world's deadliest diseases. As director of Schatz's research, Waksman took credit for the discovery, belittled Schatz's work, and secretly enriched himself with royalties from the streptomycin patent filed by the pharmaceutical company Merck. In an unprecedented lawsuit, young Schatz sued Waksman, and was awarded the title of "co-discoverer" and a share of the royalties. But two years later, Professor Waksman alone was awarded the Nobel Prize. Schatz disappeared into academic obscurity. For the first time, acclaimed author and journalist Peter Pringle unravels the intrigues behind one of the most important discoveries in the history of medicine. The story unfolds on a tiny college campus in New Jersey, but its repercussions spread worldwide. The streptomycin patent was a breakthrough for the drug companies, overturning patent limits on products of nature and paving the way for today's biotech world. As dozens more antibiotics were found, many from the same family as streptomycin, the drug companies created oligopolies and reaped big profits. Pringle uses firsthand accounts and archives in the United States and Europe to reveal the intensely human story behind the discovery that started a revolution in the treatment of infectious diseases and shaped the future of Big Pharma.
Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references
Download or read book Spitting Blood written by Helen Bynum and published by Oxford University Press. This book was released on 2015 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Few diseases have been more inextricably linked with our past than tuberculosis. The ancient Greeks called it phthisis or consumption, names still familiar in the early twentieth century. They knew that coughing up or spitting of blood were bad signs. Through the Medieval Period to the modern day, Helen Bynum explores the history and development of TB throughout the world, touching on the various discoveries that have emerged about the disease, and focusing on the clinical and experimental approaches of Rene Laennec (1781-1826) and Robert Koch (1842-1910). Therapies included miraculous touching, bleeding, travel, vaccines, sanatoria, open-air therapy, and surgery, although none proved successful. A real cure finally arrived after World War II, with anti-tuberculosis drugs, characterizing a new optimism about science, health, and society. Although concerns about TB faded away in the mid-twentieth century, the disease has now returned with a vengeance. Bynum describes the emerging picture from the World Health Organization of the difficulties in managing new drug-resistant forms of the disease that have established themselves in the developing world, and in poorer parts of large cities worldwide. The story of tuberculosis, it seems, is far from over."--
Download or read book Miracle Cure written by William Rosen and published by Penguin. This book was released on 2017-05-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.
Download or read book Tuberculosis written by Frank Ryan and published by FPR-Books Ltd. This book was released on 1992 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis is the greatest killer of all time. In this century and the previous one, it was responsible for the deaths of a thousand million human beings. Half way through the 20th century, people did not believe that a cure would ever be possible, but a few scientists throughout the world each played a part in finding that cure. The discovery changed history, yet that story has never been told.
Download or read book Women in Microbiology written by Rachel J. Whitaker and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many girls want to become scientists when they grow up, just like many boys do. But for these girls, the struggle to do what they love and to be treated with respect has been much harder because of the discrimination and bias in our society. In Women in Microbiology, we meet women who, despite these obstacles and against tough odds, have become scientific leaders and revered mentors. The women profiled in this collection range from historic figures like Alice Catherine Evans and Ruth Ella Moore to modern heroes like Michele Swanson and Katrina Forest. What binds all of these remarkable women are a passion for their work, a zest for life, a warm devotion to mentoring others—especially younger women—and a sense of justice and fairness that they are willing to fight tirelessly to obtain. Each story is unique, but each woman featured in Women in Microbiology has done so much to expand our knowledge of the natural world while also making it easier for the next generation of scientists to work collaboratively and in an atmosphere where people are judged by their intellect, imagination, skill, and commitment to service regardless of gender or race. Women in Microbiology is a wonderful collection of stories that will inspire everyone, but especially young women and men who are wondering how to find their way in the working world. Some of the names are familiar and some are lesser known, but all of the stories arouse a sense of excitement, driven by tales of new, important scientific insights, stories of overcoming adversity and breaking boundaries, and the inclusion of personal tips and advice from successful careers. These stories are proof that a person can live a balanced and passionate life in science that is rich and rewarding.
Download or read book Penicillin written by Robert Bud and published by OUP Oxford. This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author sets the discovery and use of penicillin in the broader context of social and cultural changes across the world. He examines the drug's contributions to medicine and agriculture, and investigates the global spread of resistant bacteria as antibiotic use continues to rise.
Download or read book The Demon Under the Microscope written by Thomas Hager and published by Crown. This book was released on 2006-09-19 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.
Download or read book Prize Fight written by Morton Meyers, M.D. and published by St. Martin's Press. This book was released on 2012-06-05 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: We often think of scientists as dispassionate and detached, nobly laboring without any expectation of reward. But scientific research is much more complicated and messy than this ideal, and scientists can be torn by jealousy, impelled by a need for recognition, and subject to human vulnerability and fallibility. In Prize Fight , Emeritus Chair at SUNY School of Medicine Morton Meyers pulls back the curtain to reveal the dark side of scientific discovery. From allegations of stolen authorship to fabricated results and elaborate hoaxes, he shows us how too often brilliant minds are reduced to petty jealousies and promising careers cut short by disputes over authorship or fudged data. Prize Fight is a dramatic look at some of the most notable discoveries in science in recent years, from the discovery of insulin, which led to decades of infighting and even violence, to why the 2003 Nobel Prize in Medicine exposed how often scientific objectivity is imperiled.
Download or read book The Forgotten Plague written by Frank Ryan and published by Back Bay Books. This book was released on 1994-09-14 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ryan, a physician, offers a history of the cure for tuberculosis, including accounts of the people and scientists involved. The final chapter spells out a renewed threat in the congruence of AIDS and tuberculosis.
Download or read book Nobel Lectures Physiology Or Medicine 1942 1962 written by and published by World Scientific. This book was released on 1999 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retrospectroscope written by Julius H. Comroe and published by . This book was released on 1978 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Download or read book Nanotechnology Based Approaches for Tuberculosis Treatment written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-06-10 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. - Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics - Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities - Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers
