Download or read book The Role of the Dual specificity Protein Kinase Mck1 in the Budding Yeast Saccharomyces Cerevisiae written by Derrick Tremaine Brazill and published by . This book was released on 1995 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemical and genetic analysis of Y1i113p a dual specificity mitogen activated protein kinase phosphatase in Saccharomyces cerevisiae written by Michelle Collister and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Protein Kinases in DNA Replication in Saccharomyces Cerevisiae written by S. Sweet and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The initiation of DNA replication at the onset of S phase in eukaryotic cells is a critically important and tightly regulated process. Multiple origins of replication in the genome must be co-ordinately regulated such that duplication of the chromosomes is complete before cell division, whilst also ensuring that no sections of the DNA are over-replicated. In G1 phase of the cell cycle, a large 'pre-replicative complex' (pre-RC) forms at origins consisting of a hexameric Origin Recognition Complex (ORC) as well as Cdc6, Cdt1 and another hexameric complex known as the Minichromosome Maintenance (MCM) complex. At the onset of S phase, two cell cycle regulated protein kinases, the Cyclin Dependent Kinase (CDK) and Cdc7, are activated. Phosphorylation of various proteins by these two enzymes triggers formation of large 'replisome' complexes, initiation of DNA replication from each origin, and disassembly of the pre-RCs. Pre-RC re-assembly is subsequently inhibited until kinase activity falls again after cell division. In this study, we have set about identifying substrates of both CDK and Cdc7 involved in DNA replication in the budding yeast Saccharomyces cerevisiae. Two techniques are employed, the in vitro phosphorylation of arrays of peptides and phosphorylation of pre-RCs assembled in cell-free yeast extracts. Peptide arrays provide a high throughput technique for screening large numbers of potential substrates in a single experiment, whilst pre-RC phosphorylation allows consideration of both tertiary and quaternary structures of the in vivo kinase substrate. Several potential novel substrates of both CDK and Cdc7 are revealed. Pre-RC phosphorylation also reveals a previously unreported phosphorylation of Orc1 by a third kinase which has been identified as Casein Kinase II (CKII).
Download or read book The Roles of the Elm1 and Swe1 Kinases in the Cell Cycle of the Budding Yeast Saccharomyces Cerevisiae written by Aparna Sreenivasan and published by . This book was released on 2000 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 1994 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: MBC online publishes papers that describe and interpret results of original research conserning the molecular aspects of cell structure and function.
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1995 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amebiasis written by Tomoyoshi Nozaki and published by Springer. This book was released on 2014-12-05 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents and presents new developments in the study of amebiasis, one of the neglected tropical diseases. Nearly 50 million people worldwide are infected with the pathogen Entamoeba histolytica, causing large-scale morbidity and mortality particularly in developing countries. This book will help clinicians for better diagnosis and management of the disease, researchers for initiating research projects on some of the poorly understood aspects of the disease and the pathogen, and students for updating their knowledge. The subjects covered range from genomics and molecular and cell biology to drug resistance and new drug development, highlighting major advances in recent years in our understanding due to rapid progress in genomic and other biomedical technologies, such as visualization of molecular processes. Most of the chapters provide recent information based on latest publications. A few chapters describe some of the critical methodological issues that will be helpful for students and researchers interested in getting into the field. The contributing authors include almost all the active researchers and clinicians from around the world. This book will be a useful primary material and a valuable source of information for anyone interested in understanding amebiasis, its diagnosis, and treatment. It will also be useful to those who are interested in learning about the biology of early branching eukaryotes and protist pathogens.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2012-07-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.
Download or read book Post transcriptional Regulation of Schizosaccharomyces Pombe P65cdc18 by the Cyclin Cdc2 Complex written by Monica A. Florio and published by . This book was released on 1996 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Yeasts in Biotechnology and Human Health written by Isabel Sá-Correia and published by Springer. This book was released on 2019-03-25 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses genome-based strategies to provide a holistic understanding of yeasts in Human Health and as model organisms in basic research or industrial production. Using numerous Saccharomyces cerevisiae strains and various non-conventional yeast species isolated from diverse origins, it describes essential biological processes, the biotechnological exploitation of yeast and pathogenesis control. It also demonstrates how functional and comparative genomics and the development of genome engineering tools are used in modern yeast research. The use of yeasts as experimental eukaryotic models increasingly gained prominence when several Nobel Prizes in Physiology/Medicine and Chemistry were awarded for innovative research, using yeast strains to elucidate molecular mechanisms in a wide range of human physiological processes and diseases, such as autophagy, cell cycle regulation and telomerase activity. This book offers useful insights for scientists in yeast research, clinical scientists working with yeast infectious models and for industrial researchers using applied microbiology.
Download or read book Non conventional Yeasts from Basic Research to Application written by Andriy Sibirny and published by Springer. This book was released on 2019-08-12 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume scopes several aspects of non-conventional yeast research prepared by the leading specialists in the field. An introduction on taxonomy and systematics enhances the reader’s knowledge on yeasts beyond established ones such as Saccharomyces cerevisiae. Biotechnological approaches that involve fungal utilization of unusual substrates, production of biofuels and useful chemicals as citric acid, glutathione or erythritol are discussed. Further, strategies for metabolic engineering based on knowledge on regulation of gene expression as well as sensing and signaling pathways are presented. The book targets researchers and advanced students working in Microbiology, Microbial Biotechnology and Biochemistry.
Download or read book Index Medicus written by and published by . This book was released on 2001-06 with total page 1356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book The Kinetochore written by Peter De Wulf and published by Springer Science & Business Media. This book was released on 2008-12-16 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Genetics of Industrial Yeasts written by Johannes H. de Winde and published by Springer Science & Business Media. This book was released on 2008-01-26 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, new yeast species have proven their value and novel biotechnological applications have emerged. This book compiles the multi-faceted genetic repertoire of several yeasts relevant to modern biotechnology, and describes their utilization in research and application in the light of their genetic make-up and physiological characteristics. Moreover, the book presents a thorough overview of a wide array of methodologies from classical genetics to modern genomics technologies that have been and are being used in functional analysis of yeasts.
Download or read book Protein Folding in the Cell written by and published by Elsevier. This book was released on 2002-02-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.
Download or read book RNA Polymerase III Transcription written by Robert J. White and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews and summarizes the substantial body of work that has been published on the transcription by polymerase III over the past 5 years. Progress in this field has been very rapid since 1993, and this new edition incorporates all the recent developments and offers the reader a highly detailed analysis of the current state of research on this largest and most complex of the eukaryotic RNA polymerases.
