Download or read book The role of regulatory T cells in controlling inflammatory responses written by Marco Romano and published by Frontiers Media SA. This book was released on 2023-04-17 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory T Cells in Inflammation written by Arne N. Akbar and published by Springer Science & Business Media. This book was released on 2005-03-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific interest in regulatory T cells has revived during the last decade. Initially described in the early seventies as suppressor T cells, the concept of suppressor/regulatory T cells went through turbulent times during the eighties when molecular analysis failed to identify putative suppressor genes. The constructive and elegant cellular experiments on regulatory T cells during the nineties, initiated by Shimon Sakaguchi and co-workers, however have brought these cells back into the limelight. Nowadays, regulatory T cells are regarded as essential components of the immune system, and several different subsets of regulatory T cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T cell subset. These cells act by suppressing adaptive and possibly also innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T cells are cell-contact dependent but a role for soluble factors, particularly in vivo, has been suggested as well. The aim of this book is to bring together recent developments and viewpoints in the field of CD4+CD25+ regulatory T cells and to discuss the potential use of regulatory T cells in immunotherapy of inflammatory diseases. By linking data on regulatory T cells from experimental models with recent findings from the clinic, this topical book will be of interest to immunologists and other biomedical researchers as well as clinicians that are interested in regulation and manipulation of the immune response during (chronic) inflammatory disease.
Download or read book Control of Regulatory T cell Stability Plasticity and Function in Health and Disease written by Margarita Dominguez-Villar and published by Frontiers Media SA. This book was released on 2021-03-08 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book T Cell Differentiation and Function in Tissue Inflammation written by Amit Awasthi and published by Frontiers Media SA. This book was released on 2020-03-11 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory T Cells in Inflammation written by Leonie S. Taams and published by Birkhäuser. This book was released on 2009-09-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Download or read book Regulatory T cells and Autoimmune Diseases written by Mitesh Kumar Dwivedi and published by Elsevier. This book was released on 2024-05-24 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells’ role in autoimmune disease pathogenesis and therapeutic aspects. Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine
Download or read book Regulatory T Cells written by Shimon Sakaguchi and published by . This book was released on 2006 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Control of Inflammation Helper T Cell Responses and Regulatory T Cell Function by BCL6 written by Deepali Vijay Sawant and published by . This book was released on 2012 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the molecular underpinnings underlying the development, suppressor function and stability of Tregs is particularly warranted. The transcriptional repressor BCL6 is a critical arbiter of helper T cell fate, promoting the follicular helper (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. BCL6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including myocarditis and pulmonary vasculitis, suggesting a potential role for BCL6 in Treg cell function. BCL6-deficient Treg cells are competent in controlling Th1 responses, but fail to control Th2 inflammation in an airway allergen model. Importantly, mice with BCL6 deleted specifically in the Treg lineage develop severe myocarditis, thus highlighting a critical role for BCL6 in Treg-mediated control of Th2 inflammation. BCL6-deficient Tregs display an intrinsic increase in Th2 genes and microRNA-21 (miR-21) expression. MiR-21 is a novel BCL6 gene target in T cells and ectopic expression of miR-21 directs Th2 differentiation in non-polarized T cells. MiR-21 is up-regulated in mouse models of airway inflammation and also in human patients with eosinophilic esophagitis and asthma. Thus, miR-21 is a clinically relevant biomarker for Th2-type pathologies. Our results define a key function for BCL6 in repressing Gata3 function and miR-21 expression in Tregs, and provide greater understanding of the control of Th2 inflammatory responses by Treg cells.
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Download or read book Cytokine Frontiers written by Takayuki Yoshimoto and published by Springer Science & Business Media. This book was released on 2013-10-28 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
Download or read book Regulatory T Cells in Health and Disease written by and published by Academic Press. This book was released on 2015-11-26 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. Contains contributions from leading authorities in the field of regulatory T cell biology Informs and updates on all the latest developments in the field Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer
Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Download or read book Dendritic Cell Control of Immune Responses written by Penelope Anne Morel and published by Frontiers Media SA. This book was released on 2016-07-27 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer.
Download or read book The Role of Human Regulatory T Cells in Controlling Immune Responses written by Tuisku-Tuulia Koivula and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Functional and Translational Immunology of Regulatory T Cells Tregs the Anti Tumor T Cell Response and Cancer written by Michael A. Alexander and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T cells (Tregs) are a vital component of the T cell immune system by their ability to control T cell responses that would lead to autoimmune disease. Tregs also protect damaged normal cells that are healing from T cells programmed to kill any abnormal cells in the body. Cancer (tumor) develops from normal cells and can express normal self-antigens. Tregs protect precancerous cells as if they were healing damaged cells and inhibit the anti-tumor T cell response by the use of advanced effector mechanisms, which stop the T cell immune system from effectively removing the tumor. The function of cells involved in this process is controlled by the cell membrane activation of intracellular translational pathways interacting with the nucleus that produces transcriptional proteins, which control cellular behavior such as secretion of lymphokines or cell proliferation. This book examines the function and related translational pathways of Tregs, anti-tumor T cells, and cancer cells. It relates that information to the treatment of cancer by examining human clinical trials of new immune cell-based treatments (immunotherapy). The book also proposes ways to improve those treatments by manipulating the translational pathways of immunotherapeutic cells. The hope is that these new treatment proposals stimulate positive thought about the future of cancer immunotherapy.
Download or read book CD4 CD25 Regulatory T Cells Origin Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
Download or read book From Molecules to Mothers written by Robert M. Samstein and published by . This book was released on 2013 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T (Treg) cells are critical for control of immune responses and thus maintenance of immune homeostasis in a variety of inflammatory conditions. The transcription factor Foxp3 is necessary and sufficient for Treg cell lineage development both in the thymus and the periphery and their ability to suppress immune responses. Deficiency of Foxp3 or Treg regulation results in widespread inflammation in mice and humans highlighting its essential role. However, how Treg cells function to limit inflammation in a variety of settings is poorly understood. The work described herein attempts in three studies to elucidate some of the details of how and where regulatory T cells function. In the gut, IL-10 activation of STAT3 signalling is shown to be essential for Treg cell control of Th17 inflammation and a resulting colitis suggesting that Tregs respond to and amplify existing negative regulatory circuits. Using DNase-seq and ChIP-seq Foxp3 is shown to predominantly utilize preexisting or TCR-signalling driven enhancers supporting a model of Foxp3 exploitation of a preformed enhancer landscape in order to direct Treg cell differentiation and function. Lastly, extra-thymically generated Treg cells are shown to be important for maternal fetal tolerance and the mechanisms necessary for their differentiation appear to have evolved in placental mammals. Taken together, these studies provide further insight into regulatory T cell function and offer the potential for therapeutic development in a variety of disease settings.
