Download or read book The Role of HIV 1 Envelope Glycoproteins in the Pathogenesis of HIV AIDS written by Mark James Mondero Cayabyab and published by . This book was released on 2003 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV and the Pathogenesis of AIDS written by Jay A. Levy and published by . This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The HIV 1 Envelope Glycoproteins written by Rogier Willem Sanders and published by Amsterdam University Press. This book was released on 2003-12-01 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and.
Download or read book Encyclopedia of AIDS written by Thomas J. Hope and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The HIV 1 Gp41 Envelope Subunit written by Morgan Carlson and published by . This book was released on 2004 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Idiotypes in Medicine Autoimmunity Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
Download or read book Human Retroviruses written by Bryan Cullen and published by Oxford University Press. This book was released on 1993 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Download or read book Roles of HIV Virion associated Envelope Glycoprotein in Modulating Various Cellular Pathways and Facilitating Viral Replication and Its Pathogenicity written by Xiaozhuo Ran and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV envelope glycoprotein, composed of gp41 and gp120 subunits, is a key viral protein in HIV infection and replication. The role of HIV envelope glycoprotein in viral entry and membrane fusion has been well studied. However, how HIV envelope glycoprotein modulates downstream gene expression to enhance viral replication and the underlying mechanism of this action are poorly understood. In order to better understand the role of HIV envelope glycoprotein in HIV expression and pathogenesis, my study focused on the characterization and role of the virion-associated envelope glycoprotein (vEnv) in viral transcription of HIV infected cells. My results showed that the vEnv binding to CD4 receptor and coreceptor (CCR5 or CXCR4) activates HIV transcription in HIV infected CD4+ T lymphocytes, including HIV infected cell lines and peripheral blood mononuclear cells (PBMCs) isolated from HIV aviremic patients. Through transcriptome analysis, I found that numerous cellular gene products modulated by vEnv were involved in various signaling pathways, including cellular transcription, T cell receptor signaling, cell cycle, and actin skeleton organization. Among these modulated genes, I further identified a cellular microRNA, microRNA 181A2 (miR-181A2), which is associated with the transcriptional activation by vEnv. My results revealed that miR-181A2 is downregulated upon vEnv treatment, resulting in an increase of cellular p300/CBP associated factor (PCAF) expression, thereby allowing an increased HIV LTR histone H3 acetylation and HIV transcriptional activation. Further, I also identified another vEnv-modulated cellular gene, histone deacetylase 10 (HDAC10), which is related to viral replication. The results showed the downregulation of HDAC10 benefits viral replication through promoting viral integration. Furthermore, the co-immunoprecipitation assay demonstrated that HDAC10 interacts with viral integrase by binding to integrase amino acid 55-165. Interestingly, this interaction does not alter the lysine acetylation state of integrase but specifically decreases the binding of HIV integrase to host factor LEDGF/p75, which leads to the inhibition of viral integration. In addition to regulating viral integration, the results also revealed that the progeny viral infectivity is inversely correlated with cellular HDAC10 level. In conclusion, this thesis revealed the function of vEnv during HIV replication and provided new potential targets for HIV therapy.
Download or read book Immunopathogenesis of HIV Infection written by Anthony S. Fauci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Download or read book The Neurology of AIDS written by Howard E. Gendelman, MD and published by Oxford University Press. This book was released on 2011-11-29 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Download or read book AIDS Pathogenesis written by H. Schuitemaker and published by Springer Science & Business Media. This book was released on 2000-03-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.
Download or read book HIV Molecular Organization Pathogenicity and Treatment written by John Morrow and published by Elsevier Science & Technology. This book was released on 1993 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now 12 years since the first reports of AIDS, and the disease has become a pandemic of devastating proportions. Despite the enormous social, emotional and economic costs, some rays of hope are now visible. Biomedical research into the problems presented by the disease has gained considerable momentum. The discovery of the etiologic agent, the human immunodeficiency virus (HIV), in the mid-1980's has resulted in massive efforts to characterize the organism. In addition the development of new therapies is under intense study and anti-viral and immunomodulating drugs are showing some efficiency in preliminary testing. To date, attempts to produce a protective vaccine have been only partially successful, but these investigations are continuing unabated and we can remain cautiously optimistic that these tremendous efforts may yield some promise in the medium, if not short-term, period. In compiling this volume, the authors have aimed to review key topics in the fast-moving field of HIV research and provide the reader with easy access to current literature and trends in experimentation.
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. - Written by leading experts - Contains original material, both textual and illustrative, that should become a very relevant reference material - The material is presented in a very comprehensive manner - Both researchers in the field and general readers should find relevant and up-to-date information
Download or read book HIV I Molecular Biology and Pathogenesis Clinical Applications written by and published by Academic Press. This book was released on 2000-09-26 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. - Detailed insights into viral packaging, expression, and assembly - Mechanistic understanding of how HIV interacts with receptors and infects cells - Delineation of virally encoded regulatory processes unique to HIV - Clinical Applications: - An updated review of current chemotherapeutics for HIV - New concepts in the discovery and design of novel anti-HIV drugs - The latest developments in HIV-vaccine research
Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer Science & Business Media. This book was released on 2007-11-25 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.
Download or read book HIV Infection in Children and Adolescents written by Raziya Bobat and published by Springer Nature. This book was released on 2020-02-27 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection.
Download or read book World Cancer Report 2008 written by International Agency for Research on Cancer and published by International Agency for Research on Cancer. This book was released on 2008-12-31 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The World Cancer Report 2008" provides a comprehensive overview of cancer for all those working in the field of health-care and research, and the general reader as well. It presents information on cancer patterns, diagnosis, causes and prevention concisely, clearly outlining the growing public health crisis. Simultaneously, there is a clear message of hope: although cancer is a great and growing devastating disease, it is largely preventable.
