Download or read book Ras and Cancer in the 21st Century written by Linda VanAelst and published by Perspectives Cshl. This book was released on 2018 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.
Download or read book The ras Superfamily of GTPases 1993 written by Juan Carlos Lacal and published by CRC Press. This book was released on 2017-11-22 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.
Download or read book Shringar the Ras Raj written by Ved Bhatnagar and published by Abhinav Publications. This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Shringar poetry is not simply a fresh school of poetry but is, in many respects, comparable to the great English romantic poetry excelling in the delineation of nature and flight of imagination. It is a unique effort of bringing under the umbrella of ras poetry, music, sculpture and painting, and a rare mix of scholarship and popular writing.
Download or read book Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto Oncogene written by Amita Kashyap and published by Springer. This book was released on 2014-09-08 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
Download or read book Waking and the Reticular Activating System in Health and Disease written by Edgar Garcia-Rill and published by Academic Press. This book was released on 2015-04-28 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders. First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson’s, Alzheimer’s, and other neurologic and mental diseases Offers a new way of thinking about brain function and the role of the RAS in our waking lives Written by a leading translational neuroscience researcher with contributions by specialists in the field
Download or read book The Protective Arm of the Renin Angiotensin System RAS written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Download or read book Inhibitors of the Ras Superfamily G proteins Part A written by and published by Elsevier. This book was released on 2013-08-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book Breaking the HEC RAS Code written by Christopher Goodell and published by H2ls. This book was released on 2014-10-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most powerful, yet relatively unknown features available in HEC-RAS is the HECRASController. TheHECRASController API has a wealth of procedures which allow a programmer to manipulate HEC-RAS externally by setting input data, retrieving input or output data, and performing common functions such as opening and closing HEC-RAS, changing plans, running HEC-RAS, and plotting output. HECRASController applications are seemingly endless. Not only can the retrieval and post-processing of output be automated, but with the HECRASController, real-time modeling and probabilistic experiments like Monte Carlo are possible. If you have HEC-RAS on your computer, you already have the HECRASController! "Breaking the HEC-RAS Code" explains how the HECRASController works, provides example applications of the HECRASController, and catalogs the vast array of programming procedures (with explanations and examples on how to use them) embedded in the HECRASController. This is a "must-have" book for all HEC-RAS users. Professionals: Give yourself an edge for the next proposal and do something groundbreaking with HEC-RAS. Students: Make yourself marketable by adding the skills offered in this book.
Download or read book Conquering RAS written by Asfar Azmi and published by Academic Press. This book was released on 2016-08-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities Showcases recent advancements in RAS research under one comprehensive volume Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
Download or read book Ras Superfamily Small G Proteins Biology and Mechanisms 1 written by Alfred Wittinghofer and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Download or read book Inhibitors of the Ras Superfamily G proteins Part B written by and published by Academic Press. This book was released on 2013-11-07 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins. Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts
Download or read book RAS Past Present and Future written by and published by Academic Press. This book was released on 2022-01-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. Overview of the history and development of efforts to pharmacologically inhibit RAS. Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Download or read book Troubleshooting Microsoft Technologies written by Chris Wolf and published by Addison-Wesley Professional. This book was released on 2003 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: bull; Addresses the topic on which network administrators most need help - troubleshooting. bull; Comprehensive - covers Windows Server 2003, Windows XP, Office, Active Directory, and more. bull; The first book to cover troubleshooting Microsoft networks.
Download or read book The Last Skin written by Barbara Ras and published by Penguin. This book was released on 2010-03-30 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A third collection from a poet whose "beautiful sentences weave the miraculous and mundane into a single, luminous tapestry" (The Atlanta Journal-Constitution) Barbara has won acclaim for fluid and graceful poems that touch on the small occurrences and mysteries of daily life in the hopes of finding the secret meaning beneath them. Both intimate and wide ranging, her work is unafraid of big subjects and big feelings, and sometimes comedic. Her third collection, The Last Skin, extends and develops these qualities, offering landscapes and characters both domestic and exotic, in poignant personal lyrics of precise description that investigate beauty, grief, death, fragility, time, and loss. Here is a poet engaged with the spirit as well as the political, blending the give and take of the world into her own ecstatic rhythms.
Download or read book Ras and other GTPases in Cancer From Basic to Applied Research written by Veronica Aran and published by Frontiers Media SA. This book was released on 2022-01-13 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Your Brain at Work written by David Rock and published by Harper Collins. This book was released on 2009-10-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Your Brain at Work, David Rock takes readers inside the heads—literally—of a modern two-career couple as they mentally process their workday to reveal how we can better organize, prioritize, remember, and process our daily lives. Rock, the author of Quiet Leadership and Personal Best, shows how it’s possible for this couple, and thus the reader, not only to survive in today’s overwhelming work environment but succeed in it—and still feel energized and accomplished at the end of the day.
Download or read book Oncogenic RAS dependent Reprogramming of Cellular Plasticity written by Alessandro Rimessi and published by Frontiers Media SA. This book was released on 2020-06-15 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
