Download or read book The Primate Malarias written by George Robert Coatney and published by . This book was released on 1971 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parasitism written by Claude Combes and published by University of Chicago Press. This book was released on 2001 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Parasitism, Claude Combes explores the fascinating adaptations parasites have developed through their intimate interactions with their hosts. He begins with the biology of parasites—their life cycles, habitats, and different types of associations with their hosts. Next he discusses genetic interactions between hosts and parasites, and he ends with a section on the community ecology of parasites and their role in the evolution of their hosts. Throughout the book Combes enlivens his discussion with a wealth of concrete examples of host-parasite interactions.
Download or read book Malaria Parasites and Other Haemosporidia written by Percy Cyril Claude Garnham and published by . This book was released on 1966 with total page 1234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Squirrel Monkey written by Leonard A. Rosenblum and published by Elsevier. This book was released on 2013-11-06 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Squirrel Monkey is devoted to the common South American squirrel monkey, Saimiri sciureus. In light of the growing number of squirrel monkeys being established each year in many laboratories, there appeared the need to pool existing knowledge in concise form. The present volume, the first of its kind on any single primate, attempts to meet this need. The topics that have been selected cover thoroughly areas of research in which Saimiri has been utilized. This material ranges widely from taxonomy and behavioral studies through husbandry and clinical management of the species, to investigations in aerospace medicine and in a number of basic biological sciences. Since the problems encountered in the squirrel monkey, though sometimes taking a particular form, are not unique in principle, the authors have attempted to provide an appropriate phylogenetic context for their material. It is hoped as a result that this compendium may serve as a valuable source of information during various phases of work on other subjects of primatological and comparative biological investigation as well.
Download or read book The Malaria Project written by Karen M. Masterson and published by Penguin. This book was released on 2014-10-07 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book The Making of a Tropical Disease written by Randall M. Packard and published by JHU Press. This book was released on 2021-07-13 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: A global history of malaria that traces the natural and social forces that have shaped its spread and made it deadly, while limiting efforts to eliminate it. Malaria sickens hundreds of millions of people—and kills nearly a half a million—each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did malaria disappear from other regions, and why does it persist in the tropics? From Russia to Bengal to Palm Beach, Randall M. Packard's far-ranging narrative shows how the history of malaria has been driven by the interplay of social, biological, economic, and environmental forces. The shifting alignment of these forces has largely determined the social and geographical distribution of the disease, including its initial global expansion, its subsequent retreat to the tropics, and its current persistence. Packard argues that efforts to control and eliminate malaria have often ignored this reality, relying on the use of biotechnologies to fight the disease. Failure to address the forces driving malaria transmission have undermined past control efforts. Describing major changes in both the epidemiology of malaria and efforts to control the disease, the revised edition of this acclaimed history, which was chosen as the 2008 End Malaria Awards Book of the Year in its original printing, • examines recent efforts to eradicate malaria following massive increases in funding and political commitment; • discusses the development of new malaria-fighting biotechnologies, including long-lasting insecticide-treated nets, rapid diagnostic tests, combination artemisinin therapies, and genetically modified mosquitoes; • explores the efficacy of newly developed vaccines; and • explains why eliminating malaria will also require addressing the social forces that drive the disease and building health infrastructures that can identify and treat the last cases of malaria. Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.
Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Download or read book Nonhuman Primates in Biomedical Research written by Christian R. Abee and published by Academic Press. This book was released on 2012-06-07 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout
Download or read book Occupational Health and Safety in the Care and Use of Nonhuman Primates written by National Research Council and published by National Academies Press. This book was released on 2003-06-13 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.
Download or read book Malaria Methods and Protocols written by Denise L. Doolan and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.
Download or read book The Malaria Genome Projects written by Irwin W. Sherman and published by World Scientific. This book was released on 2012 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Project came into being, the people who created it, and the cadre of scientists who are attempting to see the promise of the Project realized. The promise was: a more complete understanding of the genes of the parasite (and its vector) would provide a rational basis for the development of antimalarial drugs and vaccines, allow a better understanding of the regulation of the complex life cycle in the red blood and liver cells of the human, identify the genes the parasite uses to thwart the host immune response and the ways in which the parasite evades cure by drug treatments, as well as leading to more effective measures of control transmission. The hope was that cracking the genetic code of Plasmodium and Anopheles would reveal the biochemical Achilles heel of the parasite and its vector, leading to the development of novel drugs and better methods of control, and by finding the targets of protective immunity could result in the manufacture of effective vaccines. Through a historic approach, this book will allow for those new to the field, or those with insufficient background in the sciences, to have an easier entry point. Even scientists already working in the field may better appreciate how discoveries made in the past can impact the direction of future research.
Download or read book Aotus The Owl Monkey written by Janet F. Baer and published by Academic Press. This book was released on 2012-12-02 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first comprehensive treatment of Aotus, the nocturnal New World owl monkeys often used in behavioral and biomedical studies. Found in tropical forests from Nicaragua to Argentina, owl monkeys have been used in laboratories as model organisms for studies of diseases like malaria, and various forms of cancer, as well as studies of reproductive physiology and neuroanatomical structure and function. These and other recent studies of this fascinating primate are included in this new volume. As the only book devoted exclusively to owl monkeys, this volume is an invaluable addition to the library of anyone interested in primate biology, evolution, ecology, and behavior. - Only book devoted entirely to owl monkeys - Surveys issues that pertain to wild and captive populations - Represents the breadth of studies that model organisms can engender
Download or read book Avian Malaria Parasites and other Haemosporidia written by Gediminas Valkiunas and published by CRC Press. This book was released on 2004-10-28 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt: When studying the effects of parasites on natural populations, the avian haematozoa fulfills many of the specifications of an ideal model. Featuring a multitude of tables and illustrations, Avian Malaria Parasites and Other Haemosporidia summarizes more than a century of research on bird haemosporidians. For a long time, bird blood parasites served as important models in studying human diseases. Although now largely replaced, the wealth of data and research remain. With chapters addressing life cycles and morphology, pathogenicity, ultrastructure, geographical distribution, and illustrated keys to all known species of the parasites, this book is a masterful assessment of the biology of bird haemosporidian parasites.
Download or read book Chimpanzees in Research written by Committee on Long-Term Care of Chimpanzees and published by National Academies Press. This book was released on 1997-09-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimpanzees in biomedical and behavioral research constitute a national resource that has been valuable in addressing national health needs. Facilities that house chimpanzees owned and supported by the National Institutes of Health (NIH) have successfully met the research requirements of the scientific community. The captive chimpanzee population in the United States has grown substantially, particularly over the last decade. That growth is due primarily to the success of the NIH-sponsored Chimpanzee Breeding and Research Program, which achieved the birth numbers thought necessary to meet the projected needs of biomedical research. However, the expected level of use of the chimpanzee model in biomedical research did not materialize, and that has created a complex problem that threatens both the availability of chimpanzees for research in the future and the infrastructure required to ensure the well-being of captive chimpanzees used in biomedical research. Because the present system is fragmented, it is impossible to formulate an accurate overview of the size and nature of the chimpanzee population. But, if the chimpanzee is to continue to be used in biomedical research responsibly, effectively, and cost-effectively, we must be able to oversee, track, and coordinate the maintenance and use of chimpanzees and to control the size of the population. To assess the long-range situation and to develop, implement, and monitor the application of policies for the proper use and care of chimpanzees, an authoritative, centralized oversight structure is imperative. Once it is in place, it will be possible to refine and implement this report's recommendations.
Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders
Download or read book Human Emerging and Re emerging Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 2365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.
