Download or read book The Practice of Enantiomer Separation by Capillary Gas Chromatography written by Wilfried A. König and published by . This book was released on 1987 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gas Chromatographic Enantiomer Separation with Modified Cyclodextrins written by Wilfried A. König and published by . This book was released on 1992 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Separation Methods for Pharmaceutical and Biotechnological Products written by Satinder Ahuja and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity of small and large molecules Provides detailed information on useful chiral stationary phases (CSPs) for HPLC Includes handy information on selection of an appropriate CSP, including mechanistic studies Offers strategies for fast method development with HPLC, SFC, and CE Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
Download or read book Chiral Separations written by Gerald Gübitz and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.
Download or read book Enantiomeric Separation by Capillary Gas Chromatography Using Derivatized Cyclodextrin Stationary Phases written by Weiyong Li and published by . This book was released on 1991 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Separations written by D. Stevenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.
Download or read book The Separation of Enantiomers by Capillary Electrophoresis written by Stephen Wren and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on the principles of physical and mathematical modelling of enantiomer separation by CE. Method development strategies are shown and cyclodextrins as a popular group of chiral selectors as well as some other selectors used as buffer additives for enantiomer separation in free solution are described.
Download or read book Chromatographic Enantioseparation written by Stig G. Allenmark and published by Ellis Horwood. This book was released on 1988 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allenmark (microbiological chemistry, U. of Gothenburg) gives a thorough treatment of chiral chromatography, covering basic theory, methods (particularly stationary phase design), and applications. Treatment is self-contatined; early chapters explain principles, incorporating background material on organic stereochemistry; later ones cover instrumentation, preparation, synthesis, and analysis. Includes in-depth coverage of liquid chromatographic methods and discussion of industrial uses for large-scale preparative resolutions, including column sample capacity, chromatographic reproducability, and automatic operation. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Chiral Recognition in Separation Methods written by Alain Berthod and published by Springer Science & Business Media. This book was released on 2010-06-16 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.
Download or read book Differentiation of Enantiomers I written by Volker Schurig and published by Springer. This book was released on 2013-12-16 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Download or read book Enantiomer Separations by Preparative Gas Chromatography written by Daniel U. Staerk and published by . This book was released on 1995 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Download or read book Chiral Separations and Stereochemical Elucidation written by Quezia Bezerra Cass and published by John Wiley & Sons. This book was released on 2023-05-09 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: An expert resource for chemists using stereochemical analysis methods In Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications, a team of distinguished researchers delivers a robust and authoritative discussion of the theoretical fundamentals of chiral separation, the most commonly used chiral selectors, and stereochemical elucidation methods. The book offers expert discussions of a variety of chiral separation methods by gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), and liquid chromatography (LC). The authors also describe several methods for stereochemical elucidation, including X-ray crystallography, nuclear magnetic resonance spectroscopy, and chiroptical methods. The explored material is ideal for practicing chemists seeking a resource to help them guide method development and optimization or to explain quality control-complements during target compound production. Readers will also find: A thorough introduction to the most important advances and applications in LC, GC, CE, SFC, and preparative chromatography Comprehensive explorations of the role of 2D-LC for chiral separation methods development and applications Practical discussions of the design, mechanisms, and applications of the most commonly used chiral selectors Fulsome treatments of the theoretical backgrounds, advantages, limitations, and applications of stereochemical elucidation methods Perfect for academic and industrial chemists specially in organic, analytical chemistry and pharmaceutical analysis. Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications will also benefit biochemists, environmental analysts, forensic and medicinal chemists as well as natural product chemists and those involved with stereochemistry or structural elucidation.
Download or read book Recent Advances in Chiral Separations written by Derrick Stevenson and published by Springer. This book was released on 1990 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a Chromatographic Society International Symposium, held at the University of Surrey, Guildford, UK, September 12-15, 1989
Download or read book The Preparation of Novel Modified Cyclodextrins and Their Application in Enantioseparations by Gas Chromatography written by Sheree N. Allen and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since biological processes depend on the stereospecific creation and conversion of chiral molecules, each enantiomer of a molecule can have a different biological effect. While numerous synthetic drugs are sold in racemic form for reasons of cost and convenience, in many cases one of the two enantiomers of a drug will cause undesirable and perhaps even devastating effects. Therefore, effective methods for the separation and quantification of enantiomers are of great importance. Enantiomers can be separated only with the use of systems containing an optically active chiral selector. Modified cyclodextrins (CDs) are widely used as chiral selectors by virtue of their ability to form inclusion complexes. Because of the remarkably high efficiency, and sensitivity of chiral gas chromatography (GC), chiral separations by this method represent a preferred method for enantiomer analysis. The basic property of CDs that allows them to be successful for enantiomer separations is their ability to form selective inclusion complexes with a wide variety of organic molecules. The preparation and application of modified cyclodextrins for the GC separation of enantiomers is a focal point of this research. In effort to identify useful new derivatives, modifications involving unique and separate reaction of the secondary hydroxyl groups and/or annulations bridging the secondary oxygens have been examined. Several new cyclodextrin derivatives, e.g. per(6-OTBS-2,3-O-diformyl)-[beta]-CD, per(6-OTBS-2,3-O-cyclodimethylsilyl)-[beta]-CD, per(6-deoxy-2,3-O-cyclodimethylsilyl)-[beta]-CD and a mixed formyl/acetyl phase have been synthesized and evaluated as components of stationary phases for capillary GC. The efficiency of each new phase to separate enantiomers was evaluated against a 30 analyte panel to evaluate the influence of the different substituents on the selectivity. These enantioseparations were also compared to those observed on four commercially available chiral phases using the same 30 analyte panel. Overall, this work resulted in nine new CD derivatives and the discovery of a new chiral selector that is comparable in efficiency to what is currently commercially available.
Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2005-01-27 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Inclusion complexation of a racemic compound with a chiral host compound, which gives chiral host-chiral guest inclusion compounds, from which the chiral guest can be obtained. When this separation is combined with distillation technique, for example, enantiomer separation can be accomplished by fractional distillation in the presence of a chiral host compound. This is a modern and "green" procedure of enantiomer separation. These separation methods are described in several chapters of the book. Biological separation methods and "green" methods are covered in two chapters. Enantiomer separation by chromatography on a column containing chiral solid phase is one of the most up-to-date and well known "green" methods of enantiomer separation. Two experts in chromatography have contributed to provide two very important chapters on this method of separation. Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.
Download or read book Chiral Separations by Chromatography written by Satinder Ahuja and published by . This book was released on 2000 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large number of examples are given that will assist in the selection of a method, including thin-layer chromatography, capillary electrophoresis and membrane separations." "This book will be a reliable guide for those just starting out in pharmaceutical and related industries, as well as those with experience in the field."--Jacket.
