Download or read book The Potentialities and Limitations of the Nude Mouse written by Tatsuji Nomura and published by Fischer Gustav Verlag GmbH & Company KG. This book was released on 1977 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Nude Mouse in Oncology Research written by Epie Boven and published by CRC Press. This book was released on 2018-01-18 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2012 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Patient Derived Mouse Models of Cancer written by Robert M. Hoffman and published by Springer. This book was released on 2017-08-01 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
Download or read book Guide for the Care and Use of Laboratory Animals written by and published by National Academies. This book was released on 1985 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Potentialities and Limitations of the Nude Mouse written by and published by . This book was released on 1977 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proceedings of the Third International Workshop on Nude Mice Montana State University Bozeman Montana September 6 9 1979 Invited lectures infection and immunology written by Norman D. Reed and published by Fischer Gustav Verlag GmbH & Company KG. This book was released on 1982 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biotechnology Potentials and Limitations written by S. Silver and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: hurdle will be in the latter area. The technological hurdles will be formi dable but will not limit what happens: once the basic ideas are available, the technology will be developed. The unique part of biotechnology will be to imagine what the possibilities are. There was a discussion in several of the groups on the problems of intro ducing a novel science into a social and economic context. What biotech nologists are learning on this matter is not novel, although that does not make it any less important or difficult. People in the development of elec tronics and computers, in the pharmaceutical industry, and in many other types of industry that have grown from university research have had to face these problems in the past. It is the old situation of having to reinvent the wheel again and again. There is one aspect on which biotechnology seems to have handled this inherent difficulty better than some of our predecessor technologies: the people in the biotechnology companies by and large take a rather academic approach to free communication with one another at meetings such as this and open publication of many of their basic findings in the literature. This seems unique and certainly is different from the experience of the recent Silicone Valley Industry, which in other ways tries to emulate an academic environment, but not in open and free publication.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Using Animals in Intramural Research written by and published by . This book was released on 1987 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mononuclear Phagocytes written by R. van Furth and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 1949 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Therapeutic Potential of the Cannabinoid CB2 Receptor written by Reem Smoum and published by Frontiers Media SA. This book was released on 2022-11-14 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book JNCI Journal of the National Cancer Institute written by National Cancer Institute (U.S.) and published by . This book was released on 1987 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Male Germline Stem Cells Developmental and Regenerative Potential written by Kyle E. Orwig and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Download or read book Cancer Metastasis written by David Lyden and published by Cambridge University Press. This book was released on 2011-04-25 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
Download or read book Humanized Mice written by Tatsuji Nomura and published by Springer Science & Business Media. This book was released on 2008-03-11 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.
