Download or read book The Physics Behind and Biosensing Applications of Resonant Micro and Nanomechanical Sensors written by Philip Sutton Waggoner and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research presented herein focuses on the use of micro- and nanoelectromechanical systems (MEMS/NEMS) as mechanical resonators employed as sensors. The thesis describes the physical mechanisms underlying their use as sensors and demonstrates their utility in biosensing applications. This field is developing in the wake of the inception and widespread propagation of MEMS devices and scanned probe microscopies like atomic force or scanning tunneling microscopy. Recently there has been growing interest in their application to biological systems and the detection of low concentrations of biomolecules, where they could enable novel or deeper understandings of these systems or the onset and progression of disease. In order to push the limits of sensitivity to such levels, a full understanding of the sensing mechanisms is needed which, once attained, will shed light on appropriate sensor design parameters, materials, functional pattering, and the use of higher resonant modes. Two key themes that emerge from this work are the effect of device geometry and device optimization for use as biosensors. Especially important are the demonstrated applications of non-cantilever geometries and the results suggesting that these devices are also more sensitive and quantitative than cantilevers when the number of bound analytes on a device becomes very small. For biosensing applications, a "secondary mass labeling" technique has been developed that greatly improves device sensitivity to lightweight biomolecules specifically bound to the resonant sensors by effectively amplifying the mass of the analyte. After motivating the use of these sensors and providing a detailed discussion of the technology in general in Chapters 1 and 2, the experimental details of device fabrication and use are described in Chapter 3. Chapter 4 features in-depth discussion of the mathematical derivations and physics underlying the operation of these devices as sensors. Then in Chapter 5, the preparation of these devices for biosensing is described, and two realistic examples are demonstrated for the detection of prion proteins and prostate specific antigen. Together with the high device yield and rapid readout of devices, the results presented herein show great promise for real applications of this technology in medicine or other applications.
Download or read book Micro and Nanoelectromechanical Biosensors written by Liviu Nicu and published by John Wiley & Sons. This book was released on 2014-01-17 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most books dedicated to the issues of bio-sensing are organized by the well-known scheme of a biosensor. In this book, the authors have deliberately decided to break away from the conventional way of treating biosensing research by uniquely addressing biomolecule immobilization methods on a solid surface, fluidics issues and biosensing-related transduction techniques, rather than focusing simply on the biosensor. The aim is to provide a contemporary snapshot of the biosensing landscape without neglecting the seminal references or products where needed, following the downscaling (from the micro- to the nanoscale) of biosensors and their respective best known applications. To conclude, a brief overview of the most popularized nanodevices applied to biology is given, before comparing biosensor criteria in terms of targeted applications.
Download or read book Biosensors written by Toonika Rinken and published by BoD – Books on Demand. This book was released on 2015-09-24 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays, the implementation of novel technological platforms in biosensor-based developments is primarily directed to the miniaturization of analytical systems and lowering the limits of detection. Rapid scientific and technological progress enables the application of biosensors for the online detection of minute concentrations of different chemical compounds in a wide selection of matrixes and monitoring extremely low levels of biomarkers even in living organisms and individual cells. This book, including 16 chapters, characterizes the present state of the art and prospective options for micro and nanoscale activities in biosensors construction and applications.
Download or read book Microfluidic Biosensors written by Wing Cheung Mak and published by Elsevier. This book was released on 2022-11-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices. - Presents an in-depth overview of microfluidic biosensors and associated emerging technologies such as printed microfluidics and novel transducers - Addresses a range of microfluidic biosensors with device configurations ranging from 2D to 4D levels - Includes the commercialization aspects of microfluidic biosensors that provide insights for scientists and engineers in research and development
Download or read book Label Free Biosensing written by Michael J. Schöning and published by Springer. This book was released on 2018-07-20 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices
Download or read book Molecular Sensors and Nanodevices written by John X. J. Zhang and published by Academic Press. This book was released on 2018-11-19 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering, Second Edition is designed to be used as a foundational text, aimed at graduates, advanced undergraduates, early-career engineers and clinicians. The book presents the essential principles of molecular sensors, including theories, fabrication techniques and reviews. In addition, important devices and recently, highly-cited research outcomes are also cited. This differentiates the book from other titles on the market whose primary focus is more research-oriented and aimed at more of a niche market. - Covers the fundamental principles of device engineering and molecular sensing, sensor theories and applications in biomedical science and engineering - Introduces nano/micro fabrication techniques, including MEMS, bioMEMS, microTAS and nanomaterials science that are essential in the miniaturization of versatile molecular sensors - Explores applications of nanomaterials and biomaterials, including proteins, DNAs, nanoparticles, quantum dots, nanotubes/wires and graphene in biomedicine
Download or read book Macro Micro and Nano Biosensors written by Mahendra Rai and published by Springer Nature. This book was released on 2021-01-04 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes an international group of researchers who present the latest achievements in the field of enzyme, immune system, and microbial and nano-biosensors. It highlights the experimental evidence for formation of biological fuel cells (BFCs)-which has a dual purpose – as a device that produces electricity and the systems which produce it simultaneously cleaning up the environment from polluting organic compounds. Considering the work in the field of macro, micro and nano-biosensors, considerable attention is paid to the use of nanomaterials for the modification of working electrodes. Nanomaterials in some cases can significantly improve the parameters of analytical systems. Readers will be interested in the projection of the presented theoretical and experimental materials in the field of practical application of modern analytical developments. The presented results in many cases imply the possibility of using the created models of macro, micro and nano-biosensors, and biofuel elements in the field of health, and protection/restoration of the environment. It includes information about all existing types of transducers of signals in biosensors – electrochemical, optical and quantum-optics, thermoelectric, data of atomic force microscopy, piezoelectric, and more. On the basis of these principles, descriptions are given about the functioning of macro, micro and nano- biosensors for the detection of compounds used in medicine, detection of compounds that clog the environment, and thus affect human health, for compounds that are potentially the basis for the production of drugs, for the selection of compounds that have medicinal activity, for immunodetection, and to assess the quality of food. These questions form the basis of research carried out in the field of biosensors in the world. Since the described models of biosensors have high sensitivity, high measurement speed and selectivity, the described results attract the attention of both the ordinary reader and business class specialists who create and implement analytical technologies. This book is very useful for researchers in life sciences, chemical sciences, physics, and engineering. In addition, it will be useful for the persons working in industry. Advanced technologies specialists will be attracted by the novelty of the proposed solutions and their relevance and ease of implementation. Since the studies contain sections describing the parameters of different biosensors, BFCs, they are easily navigated into assessing the effectiveness of the practical use of the proposed device. The relevant sections indicate such characteristics as detection ranges, life span, type of biological material used, the method of formation of the bio-receptor part. These parameters are of interest to both developers of new models of biosensors and BFC, and their manufacturers.
Download or read book Biosensors Nanotechnology written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-06-26 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed reviews of a range of nanostructures used in the construction of biosensors as well as the applications of these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields Biological sensing is a fundamental tool for understanding living systems, but also finds practical application in medicine, drug discovery, process control, food safety, environmental monitoring, defense, and personal security. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation, and computing. Advances in telecommunications, expert systems, and distributed diagnostics prompt us to question the current ways we deliver healthcare, while robust industrial sensors enable new paradigms in R&D and production. Despite these advances, there is a glaring absence of suitably robust and convenient sensors for body chemistries. This book examines some of the emerging technologies that are fueling scientific discovery and underpinning new products to enhance the length and quality of our lives. The 14 chapters written by leading experts cover such topics as: ZnO and graphene microelectrode applications in biosensing Assembly of polymers/metal nanoparticles Gold nanoparticle-based electrochemical biosensors Impedimetric DNA sensing employing nanomaterials Graphene and carbon nanotube-based biosensors Computational nanochemistry study of the BFPF green fluorescent protein chromophore Biosynthesis of metal nanoparticles Bioconjugated-nanoporous gold films in electrochemical biosensors The combination of molecular imprinting and nanotechnology Principles and properties of multiferroics and ceramics
Download or read book Cell based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
Download or read book Biosensors and Their Applications written by Victor C. Yang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biosensor is a device in which a bioactive layer lies in direct contact with a transducer whose responses to change in the bioactive layer generate eloctronic signals for interpretation. The bioactive layer may consist of membrane-bound enzymes, anti-bodies, or receptors. The potential of this blend of electronics and biotechnology includes the direct assay of clinically important substrates (e.g. blood glucose) and of substances too unstable for storage or whose concentrations fluctuate rapidly. Written by the leading researchers in the field, this book reflects the most current developments in successfully constructing a biosensor. Major applications are in the fields of pharmacology, molecular biology, virology and electronics.
Download or read book Biosensing and Micro Nano Devices written by Pranjal Chandra and published by Springer Nature. This book was released on 2022-07-03 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews applications of nanomaterial and nanodevices in the food industry. It also discusses the advanced bioanalytical techniques, including Enzyme-Linked Immunosorbent Assay (ELISA), immunoanalytical techniques, and monoclonal antibody-based immunological techniques for detecting food adulterations and allergens. It comprehensively covers electrode modification and nano-engineered fabrication of biosensors to enhance their functionalities for utilization in food industries. The book highlights the utilization of nanobiosensors for food safety and quality analysis, such as detection of toxin, food-borne pathogen, allergen, evaluation of toxicity etc. Further, it also summarizes the recent advances in nanodevices such as nano-systems, nano-emulsions, nanopesticides, and nanocapsules and their applications in the food industry. Lastly, it covers nanomaterial-based sensors for drug analysis in diverse matrices. It serves as an invaluable source of information for professionals, researchers, academicians, and students related to food science and technology.
Download or read book Biosensors Essentials written by Gennady Evtugyn and published by Springer Science & Business Media. This book was released on 2013-10-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, biosensors are broadly applied in research, clinical diagnosis and monitoring, as well as in pharmaceutical, environmental or food analysis. In this work, the author presents the essentials that advanced students and researchers need to know in order to make full use of this technology. This includes a description of biochemical recognition elements, such as enzymes, antibodies, aptamers or even whole cells. Various signal transducers such as electrochemical and optical transducers, luminescence devices and advanced techniques such as quartz crystal microbalances and MEMS systems are covered as well. Current applications are introduced through various case studies, rounded out by a forward-looking chapter on the prospects for biosensor development offered by nanotechnology, lab-on-a-chip, and biomimetic systems.
Download or read book Biosensors written by Tran Minh Cahn and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of all the recent discoveries in biotechnology, that of biosensor is one of those which has seen an exponential expansion over the last few years. This evolution corresponds with the increasing need for measuring devices that can follow continuously changing biological processes. Biosensors can meet this need provided that their signals include all the information necessary for an understanding of the process, especially concerning the nature and concentration of the species present in the sample medium. It is well known that sensors form the basis of all instrumental analysis systems, but they also represent the limiting factors of such systems. In this book, we restrict ourselves to the description and study of sensors, leaving aside the different aspects of signal and data treatment. We believe, however, that it is important to stress the multifaceted character of biosensors, and the applications and economic factors which follow. Biosensor construction is essentially based on the immobilization of a bioreceptor on the corresponding transducer. The reader will find that there are a large variety of techniques for immobilizing enzymes, cofactors and mediators, and even microorganisms, immunoagents, e now commercially available. Other types of tissues, and organelles. A large part of this book is devoted to enzyme biosensors are discussed, with regard to both the principles of their sensors, which is hardly surprising considering that they have been operation, and their construction.
Download or read book Effect of Support Compliance on the Resonant Behavior of Microcantilever based Sensors in Viscous Fluids written by Rabin Maharjan and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Resonant microcantilevers are often considered for use in chemical sensing and biosensing applications. However, when excited in the conventional transverse flexural mode, their performance in liquids is severely compromised. Theoretical and experimental studies have shown that the detrimental effects of the liquid may be mitigated by operating the microcantilever in lateral flexure, especially for microbeams having smaller length-to-width (L/b) ratios. However, for these most promising geometries the predictions of existing models tend to diverge from experimental data for resonant frequency (fres) and quality factor (Q). A likely reason for these discrepancies is support compliance, which has been neglected in existing models. Thus, the derivation of an analytical model for the lateral-mode dynamic response of a microcantilever in a viscous fluid, including the effects of support compliance, is warranted and is the focus of this dissertation. Analytical solutions for natural frequency and Q are first obtained for the free-vibration case, followed by solutions for the forced-vibration response when the cantilever is excited by an imposed harmonic relative rotation near the support (simulating electrothermal actuation). Values of fres and Q are extracted from the response spectra for the tip deflection and the bending strain near the support. The support compliance (required as model input) is analytically related to device dimensions by employing dimensional analysis and 3-D FEA. The analytical results for the resonant characteristics are also related to sensor performance metrics (sensitivity and limit of detection), thus permitting one to exploit the potential of lateral-mode microcantilever-based liquid-phase sensors. The impact of support compliance, fluid resistance, and beam dimensions on the free- and forced-vibration response are explored, as are the differences associated with the two output signals. Comparisons of results with experimental data show a marked improvement over the previous rigid-support models for smaller L/b values. For the practical ranges of parameters considered the model indicates that, at smaller L/b values, support compliance may reduce Q by up to 1̃4% and fres and mass sensitivity (Sm) by up to 2̃1%. Conversely, for L/b>15 the support compliance effects are no more than 2% on Q and 4% on fres and Sm.
Download or read book Biosensors written by Tran Minh Cahn and published by Springer. This book was released on 2013-08-01 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of all the recent discoveries in biotechnology, that of biosensor is one of those which has seen an exponential expansion over the last few years. This evolution corresponds with the increasing need for measuring devices that can follow continuously changing biological processes. Biosensors can meet this need provided that their signals include all the information necessary for an understanding of the process, especially concerning the nature and concentration of the species present in the sample medium. It is well known that sensors form the basis of all instrumental analysis systems, but they also represent the limiting factors of such systems. In this book, we restrict ourselves to the description and study of sensors, leaving aside the different aspects of signal and data treatment. We believe, however, that it is important to stress the multifaceted character of biosensors, and the applications and economic factors which follow. Biosensor construction is essentially based on the immobilization of a bioreceptor on the corresponding transducer. The reader will find that there are a large variety of techniques for immobilizing enzymes, cofactors and mediators, and even microorganisms, immunoagents, e now commercially available. Other types of tissues, and organelles. A large part of this book is devoted to enzyme biosensors are discussed, with regard to both the principles of their sensors, which is hardly surprising considering that they have been operation, and their construction.
Download or read book Localized Surface Plasmon Resonance Based Nanobiosensors written by Yi-Tao Long and published by Springer. This book was released on 2014-04-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the fundamentals and applications of the localized surface plasmon resonance (LSPR) property of noble metallic nanoparticles, with an emphasis on the biosensing applications of plasmonic nanoparticles, especially in living cell imaging and photothermal therapy. It provides an overview of the different operating principles of plasmonic sensors, particularly the single-nanoparticle-based detections, and a series of creative biosensors based on the modulation of different parameters of nanoparticles (particle size, shape, composition and surrounding medium) for label-free detection. The interparticle coupling effect, plasmon resonance energy transfer, electron transfer on plasmonics surface are also covered in this book. This book is intended for graduate students and researchers working in the interdisciplinary field combining chemistry, biology, material science and nanophotonics. Yi-Tao Long is a Professor at the School of Chemistry and Molecular Engineering, East China University of Science and Technology, China.
Download or read book Biosensors written by M Lambrechts and published by CRC Press. This book was released on 2019-08-30 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to selectively and quantitatively detect the presence of specific compounds. Balancing basics, principles, and case studies, Biosensors: Microelectrochemical Devices covers the theory and applications of one class of biosensor-microelectrochemical devices. The book clearly explains microelectronic techniques used to produce these cheap, fast reacting, and disposable sensors with the aid of helpful diagrams and tables. Researchers and postgraduates active in the field of chemical sensors, analytical chemistry, or microelectronics will find this an invaluable reference.
