Download or read book The New England Journal of Medicine written by and published by . This book was released on 1846 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Download or read book Exploratory Study of Women in the Health Professions Schools written by Urban and Rural Systems Associates and published by . This book was released on 1976 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Towards New Therapies for Parkinson s Disease written by David Finkelstein and published by BoD – Books on Demand. This book was released on 2011-11-02 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Download or read book Annotated bibliography written by Urban and Rural Systems Associates and published by . This book was released on 1976 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Accidental written by Tim James and published by Robinson. This book was released on 2024-04-04 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Who said science was dry? Certainly not Tim James' New York Post 'James writes with infectious enthusiasm and optimism' Kirkus Reviews 'A science teacher by profession, Mr. James knows how to get his audience's attention' Wall Street Journal 'Humorous, yet deep' Professor Charles Antoine A rip-roaring adventure through science gone wrong, and accidentally changing humanity (mostly) for the better. We may imagine that science is a process of breakthroughs and light bulb moments. But in reality, science goes wrong 99% of the time. Almost every idea a scientist comes up with is quickly disproved by a failed experiment or rival research. Science moves at a rate of inches per decade and we often like it that way. But occasionally, just occasionally, a complete fluke happens and changes everything as we know it. From an untimely sneeze in a petri dish leading to the groundbreaking creation of antibiotics, to the incredible discovery of microwaves via melted chocolate, Accidental is a rip-roaring adventure through science gone wrong, and accidentally changing humanity for the better.

Download or read book Seeking Sickness written by Alan Cassels and published by Greystone Books Ltd. This book was released on 2012-04-30 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Alan Cassels strips layers of expectation, hype, jargon, false-starts, and conflicts of interest off the medical screening mantra.” —Nortin M. Hadler, author of Worried Sick Why wouldn’t you want to be screened to see if you’re at risk for cancer, heart disease, or another potentially lethal condition? After all, better safe than sorry. Right? Not so fast, says Alan Cassels. His Seeking Sickness takes us inside the world of medical screening, where well-meaning practitioners and a profit-motivated industry offer to save our lives by exploiting our fears. He writes that promoters of screening overpromise on its benefits and downplay its harms, which can range from the merely annoying to the life threatening. If you’re facing a screening test for breast or prostate cancer, high cholesterol, or low testosterone, someone is about to turn you into a patient. You need to ask yourself one simple question: Am I ready for all the things that could go wrong? “With engaging clarity backed by academic rigor, Cassels discusses a variety of popular investigational procedures . . . an excellent way to start the important process of self-education.” —Quill & Quire “Smartly written and very readable.” —Brian Goldman, MD, author of The Secret Language of Doctors “Cassels tackles this touchy topic, looking at it test by test. His overarching message is that modern medicine has ‘overpromised’ with claims that screening will save our lives. He contends that with the lack of hard evidence on benefits, the evidence of harm from by such screening, as well as the multi-billion dollar interests at stake, we should approach this kind of screening with great precaution.” —Canadian Women’s Health Network

Download or read book Demography Analysis and Synthesis Four Volume Set written by Graziella Caselli and published by Academic Press. This book was released on 2006-01-03 with total page 2857 pages. Available in PDF, EPUB and Kindle. Book excerpt: This four-volume collection of over 140 original chapters covers virtually everything of interest to demographers, sociologists, and others. Over 100 authors present population subjects in ways that provoke thinking and lead to the creation of new perspectives, not just facts and equations to be memorized. The articles follow a theory-methods-applications approach and so offer a kind of "one-stop shop" that is well suited for students and professors who need non-technical summaries, such as political scientists, public affairs specialists, and others. Unlike shorter handbooks, Demography: Analysis and Synthesis offers a long overdue, thorough treatment of the field. Choosing the analytical method that fits the data and the situation requires insights that the authors and editors of Demography: Analysis and Synthesis have explored and developed. This extended examination of demographic tools not only seeks to explain the analytical tools themselves, but also the relationships between general population dynamics and their natural, economic, social, political, and cultural environments. Limiting themselves to human populations only, the authors and editors cover subjects that range from the core building blocks of population change--fertility, mortality, and migration--to the consequences of demographic changes in the biological and health fields, population theories and doctrines, observation systems, and the teaching of demography. The international perspectives brought to these subjects is vital for those who want an unbiased, rounded overview of these complex, multifaceted subjects. Topics to be covered: * Population Dynamics and the Relationship Between Population Growth and Structure * The Determinants of Fertility * The Determinants of Mortality * The Determinants of Migration * Historical and Geographical Determinants of Population * The Effects of Population on Health, Economics, Culture, and the Environment * Population Policies * Data Collection Methods and Teaching about Population Studies * All chapters share a common format * Each chapter features several cross-references to other chapters * Tables, charts, and other non-text features are widespread * Each chapter contains at least 30 bibliographic citations

Download or read book Organelle and Molecular Targeting written by Lara Scheherazade Milane and published by CRC Press. This book was released on 2021-12-27 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Download or read book Census Reports Tenth Census The newspaper and periodical press written by United States. Census Office and published by . This book was released on 1884 with total page 1290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Health Care Management and the Law written by Hammaker and published by Jones & Bartlett Learning. This book was released on 2017-03-02 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health Care Management and the Law-2nd Edition is a comprehensive practical health law text relevant to students seeking the basic management skills required to work in health care organizations, as well as students currently working in health care organizations. This text is also relevant to those general health care consumers who are simply attempting to navigate the complex American health care system. Every attempt is made within the text to support health law and management theory with practical applications to current issues.

Download or read book Science and Technology Policy in the United States written by Sylvia Kraemer and published by Rutgers University Press. This book was released on 2006-06-20 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the latter half of the twentieth century, federal funding in the United States for scientific research and development increased dramatically. Yet despite the infusion of public funds into research centers, the relationship between public policy and research and development remains poorly understood. How does the federal government attempt to harness scientific knowledge and resources for the nation's economic welfare and competitiveness in the global marketplace? Who makes decisions about controversial scientific experiments, such as genetic engineering and space exploration? Who is held accountable when things go wrong? In this lucidly-written introduction to the topic, Sylvia Kraemer draws upon her extensive experience in government to develop a useful and powerful framework for thinking about the American approach to shaping and managing scientific innovation. Kraemer suggests that the history of science, technology, and politics is best understood as a negotiation of ongoing tensions between open and closed systems. Open systems depend on universal access to information that is complete, verifiable, and appropriately used. Closed systems, in contrast, are composed of unique and often proprietary features, which are designed to control usage. From the Constitution's patent clause to current debates over intellectual property, stem cells, and internet regulation, Kraemer shows the promise-as well as the limits-of open systems in advancing scientific progress as well as the nation's economic vitality.

Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Download or read book Guyana from Slavery to the Present written by Ramesh Gampat and published by Xlibris Corporation. This book was released on 2015-04-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is common knowledge that slavery and indenture were characterized by long hours of physical labor, restriction of movement and other basic human freedoms, and severe punishment for violations of draconian labor laws. Less well known is the fact that nutrition was very deficient and a range of infectious diseases maimed, debilitated and killed on a large scale. In trying to narrow the knowledge gap with respect to Guyana, Ramesh Gampat shows that extremely poor sanitary conditions, awful hygiene and malnutrition hastened widespread infections and created a vicious cycle. The British protected its own soldiers, officials and colonists by establishing a medical enclave that lasted until Emancipation in 1838. Former slaves were then quarantined to neglected and decaying villages and Indians to plantations. Concern with health conditions appeared only during periods of epidemics and even then it was essentially for the protection of Europeans. Colonial medicine opened the way for stereotyping, labeling, racialization of disease, neutralization of potential leaders in the struggle for justice, and crystallization of the view that Europeans were superior to Blacks and Indians. Shorter stature and shorter life expectancy are good indications that slaves and indentured immigrants fared considerably less well than Europeans. Several infectious diseases sickened and fell Blacks and Indians, including malaria and undefined fevers, pneumonia and bronchitis, diarrhea and enteritis, tuberculosis, pneumonia and hookworm. The conquest of malaria in the early 1950s accelerated the epidemiological transition from communicable to chronic noncommunicable diseases, and today NCDs account for some three-quarters of all deaths in Guyana. Malaria has reemerged, fueled by a gold boom that consumes huge amounts of mercury. The potentially adverse public health consequences of this relatively new dynamic, the combined trio, have been neglected.

Download or read book Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks written by Yong Sang Song and published by Elsevier. This book was released on 2024-06-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment.The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. Additionally, it discusses tumor evolution during chemotherapy and metastasis, and future perspectives on identification and validation of biomarkers using liquid biopsy.This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors. - Discusses how to apply tumor microenvironment knowledge to diagnosis, prediction of prognosis, and individualized treatment of cancer - Provides readers with up-to-date knowledge on translational medicine, focusing on bench-to-bedside approach for cancer treatment and diagnosis - Presents collaborative research works from the perspectives of medical doctors, cancer researchers, basic biological scientists, and bioinformaticians to provide integrative insights on tumor microenvironment

Download or read book Exploratory Study of Women in the Health Professions Schools Bibliography and annotated bibliography written by Urban and Rural Systems Associates and published by . This book was released on 1976 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Germs at Bay written by Charles Vidich and published by Bloomsbury Publishing USA. This book was released on 2021-01-19 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines America's experience with a wide range of quarantine practices over the past 400 years and the political, economic, immigration, and public health considerations that have prompted success or failure within the evolving role of public health. The novel strain of coronavirus that emerged in late 2019 and became a worldwide pandemic in 2020 is only one of more than 87 new or emerging pathogens discovered since 1980 that have posed a risk to public health. While many may consider quarantine an antiquated practice, it is often one of the only defenses against new and dangerous communicable diseases. Tracing the United States' quarantine practices through the colonial, postcolonial, and modern eras, Germs at Bay provides an eye-opening look at how quarantine has worked despite routine dismissal of its value. This book is for anyone seeking to understand the challenges of controlling the spread of COVID-19 and helps readers internalize the lessons learned from the pandemic. Few titles provide this level of primary source data on the United States' long reliance on quarantine practices and the political, social, and economic factors that have influenced them.