Download or read book The Na H Exchanger written by Larry Fliegel and published by New York : Springer. This book was released on 1996 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Sodium Hydrogen Exchanger written by Morris Karmazyn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.
Download or read book Na H Exchange written by S. Grinstein and published by CRC Press. This book was released on 2018-05-04 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prepared by leading scientists in the field, these volumes compile for the first time, concise, up-to-date reviews of several aspects of the basic properties, distribution, function and regulation of the Na+/H+ antiport. In addition, current methods and the use of inhibitors and ligands for the study of the exchanger are described. These volumes are indispendable to researchers and students in the areas of ion transport, membrane biology and cellular physiology.
Download or read book The Alkali Metal Ions Their Role for Life written by Astrid Sigel and published by Springer. This book was released on 2016-02-09 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NA H EXCHANGE written by Sergio Grinstein and published by CRC-Press. This book was released on 1988-10-31 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prepared by leading scientists in the field, these volumes compile for the first time, concise, up-to-date reviews of several aspects of the basic properties, distribution, function and regulation of the Na+/H+ antiport. In addition, current methods and the use of inhibitors and ligands for the study of the exchanger are described. These volumes are indispendable to researchers and students in the areas of ion transport, membrane biology and cellular physiology.
Download or read book Spotlight on the Na H Exchanger written by and published by . This book was released on 1995 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Na H and K H Exchangers in Amphiuma Erythrocyte written by Hector M. Maldonado and published by . This book was released on 1992 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Na H Exchanger in Blood brain Barrier Endothelial Cells written by Tina Iun San Lam and published by . This book was released on 2009 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phosphorylation of Na H Exchanger NHE 3 is Necessary But Not Sufficient for the Acute Regulation of NHE 3 Activity by Protein Kinase C written by Michael Robert Wiederkehr and published by . This book was released on 1998 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An NMR based Approach to the Structural and Functional Investigation of the Na H Exchanger NHE1 written by Brian L. Lee and published by . This book was released on 2013 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Na[superscript +]/H[superscript +] exchanger isoform 1 (NHE1) is the predominant isoform in mammalian cells, and regulates intracellular pH and ion concentrations. NHE1 also interacts with numerous proteins and signalling pathways. Consequently, it has been found to influence cell volume, growth, differentiation, and motility, and has roles in heart disease and cancer. While a wealth of biochemical and physiological data is available on NHE1, little is known about its structure or mechanism of function. In this thesis, a "divide and conquer" approach was used to study the structure and function of NHE1. The structures of individual transmembrane (TM) segments were determined using nuclear magnetic resonance (NMR) spectroscopy, and the function of the TM segments in the full protein were investigated using site-directed mutagenesis in cultured cells. We first examined the structures and functions of the second (EL 2) and fourth (EL 4) extracellular loops of NHE1. Both loops contained functionally important residues, however, EL 2 was found to be structured by NMR while EL 4 was unstructured. Next, we investigated two critical TM segments in NHE1, TM VI and TM XI, as well as TM IV of sod2, a yeast Na[superscript +]/H[superscript +] exchanger. These TM segments were found to have unusual structures consisting of a N- and C-terminal alpha-helix, with an extended segment in between, and the structures correlated well with the functional data. We also looked at larger regions of NHE1 using NMR to examine the TM--TM interactions in the protein, starting with a structure of a two-TM segment of NHE1, TM VI--VII. We also present preliminary NMR experiments on two three-TM segments, TM V--VII and TM X--XII, as well as full-length Escherichia coli NhaA. Overall, the "divide and conquer" approach has allowed us to successfully examine the structures and functions of single-TM segments of NHE1. Furthermore, studies on multi-TM segments and NhaA suggest that we may be able to assemble the structure of NHE1 from its segments or even study the complete protein by NMR spectroscopy.
Download or read book Na H Antiporter written by Marc Alan Post and published by . This book was released on 1992 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Function and Regulation of NA H Exchanger Isoform 1 in Neuronal Ischemic Damage written by Jing Luo and published by . This book was released on 2007 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Control and Coordination of the Na H and K H Exchangers in Amphiuma Tridactylum Red Blood Cells written by Alejandro Ortiz-Acevedo and published by . This book was released on 2000 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
