Download or read book The Multiple Inert Gas Elimination Technique MIGET written by Susan R. Hopkins and published by Springer. This book was released on 2017-12-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized gas chromatography and sophisticated mathematics developed in the early 1970’s. Essentially, nobody possesses knowledge of all its elements except for its original developers, and while some practical and theoretical aspects have been published over the years, none have included the level of detail that would be necessary for a potential user to adopt and understand the technique easily. This book is unique in providing a highly detailed, comprehensive technical description of the theory and practice underlying the MIGET to help potential users set up the method and solve problems they may encounter. But it is much more than a reference manual – it is a substantial physiological and mathematical treatise in its own right. It also has a wide applicability – there is extensive discussion of the common biological problem of quantitative inference. The authors took measured whole-lung gas exchange variables, and used mathematical procedures to infer the distribution of ventilation and blood flow from this data. In so doing, they developed novel approaches to answer the question: What are the limits to what can be concluded when inferring the inner workings from the “black box” behavior of a system? The book details the approaches developed, which can be generalized to other similar distributed functions within tissues and organs. They involve engineering approaches such as linear and quadratic programming, and uniquely use mathematical tools with biological constraints to obtain as much information as possible about a “black box” system. Lastly, the book summarizes the hundreds of research papers published by a number of groups over the decades in a way never before attempted in order to marshal the world’s literature on the topic and to provide in one place the wealth of important discoveries, both physiological a nd clinical, enabled by the technique.
Download or read book The Multiple Inert Gas Elimination Technique Current Methodology at the U S Army Institute of Surgical Research written by and published by . This book was released on 2002 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intrapulmonary causes of hypoxemia include alveolar hypoventilation, ventilation- perfusion (VA/Q) inequality, shunt, and diffusion limitation to oxygen. In the late 1970s, P.D. Wagner developed the Multiple Inert Gas Elimination Technique (MIGET), a method of assessing VA/Q inequality (VA/Q mismatch) and shunt. It can also be used to measure diffusion limitation. In MIGET, the lung is considered as a set of 50 respiratory units, each with a different VA/Q ratio. Six inert gases of varying solubility are infused, and the arterial, mixed venous, and expired air concentrations of the gases are measured under steady-state conditions. Then, distribution of blood flow and ventilation to each of the 50 compartments is calculated. Although technically challenging, this method can be applied in a wide range of basic and clinical settings, and enables the evaluation Of VA/Q mismatch in a relatively low-risk, non-invasive fashion. This report describes the MIGET methodology from a technical standpoint, as currently performed at this Institute. General set-up; assessment of the gas chromatograph instrument's linearity; preparation and infusion of the 6-gas solution; specimen collection; specimen processing, and data analysis are covered in detail. Creation of a new, complex, multi-ramped GC program is described. Instructional videos form part of the multimedia CD-R0M version of this report.
Download or read book Applied Physiology in Intensive Care Medicine written by Michael R. Pinsky and published by Springer Science & Business Media. This book was released on 2007-05-19 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Te practice of intensive care medicine is at the very forefront of titration of treatment andmonitoringresponse. Te substrateofthiscareisthe criticallyill patientwho,by defnition, is at the limits of his or her physiologic reserve. Such patients need immediate, aggressive but balanced life-altering interventions to minimize the detrimental aspects of acute illness and hasten recovery. Treatmentdecisionsandresponsetotherapyareusually assessed by measures of physiologic function, such as assessed by cardio-respiratory monitoring. However, how one uses such information is ofen unclear and rarely supported by prospective clinical trials. In reality, the bedside clinician is forced to rely primarily on physiologic principles in determining the best treatments and response to therapy. However, the physiologic foundation present in practicing physicians is uneven and occasionally supported more by habit or prior training than science. A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o cia t ed r e vie w a r tic les o v er t h e s a m e in t er val t ha t a ls o addr ess e d t hes e cen tral issues.
Download or read book Pulmonary Gas Exchange written by G. Kim Prisk and published by Biota Publishing. This book was released on 2013-08-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lung receives the entire cardiac output from the right heart and must load oxygen onto and unload carbon dioxide from perfusing blood in the correct amounts to meet the metabolic needs of the body. It does so through the process of passive diffusion. Effective diffusion is accomplished by intricate parallel structures of airways and blood vessels designed to bring ventilation and perfusion together in an appropriate ratio in the same place and at the same time. Gas exchange is determined by the ventilation-perfusion ratio in each of the gas exchange units of the lung. In the normal lung ventilation and perfusion are well matched, and the ventilation-perfusion ratio is remarkably uniform among lung units, such that the partial pressure of oxygen in the blood leaving the pulmonary capillaries is less than 10 Torr lower than that in the alveolar space. In disease, the disruption to ventilation-perfusion matching and to diffusional transport may result in inefficient gas exchange and arterial hypoxemia. This volume covers the basics of pulmonary gas exchange, providing a central understanding of the processes involved, the interactions between the components upon which gas exchange depends, and basic equations of the process.
Download or read book Near real Time Pulmonary Shunt and Dead Space Measurement with Multiple Inert Gas Elimination Technique MIGET by Micropore Membrane Inlet Mass Spectrometry MMIMS written by Daniel Gerber and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods of Measuring and Monitoring Atmospheric Sulfur Dioxide written by Seymour Hochheiser and published by . This book was released on 1964 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pulmonary Function Testing written by David A. Kaminsky and published by Springer. This book was released on 2018-10-04 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a unique, comprehensive resource for physicians and scientists training in pulmonary medicine and learning about pulmonary function testing. Pulmonary function testing and the physiological principles that underlie it are often poorly understood by medical students, residents, fellows and graduate students training in the medical sciences. One reason is that students tend to get overwhelmed by the basic mathematical descriptions that explain the working of the respiratory system and the principles of pulmonary function testing. Another reason is that too many approaches focus on the math without explaining the clinical relevance of these principles and the laboratory testing that enables us to measure the very lung function that these principles are describing. This book answers that need by providing a series of chapters that guide the reader in a natural order of learning about the respiratory system. In particular, after a general overview of the structure-function design of the lung and the history of pulmonary function testing, authors begin with the drive to breathe, and then follow the pathway of air as it is drawn into the lung, undergoes gas exchange, and is then exhaled back out again. Each chapter focuses on the key principles and corresponding pulmonary function tests that explain each step in this pathway. Each chapter is written by at least two experts, one with expertise in the underlying physiology, and the other with expertise in the clinical testing and application of pulmonary function testing in practice. Many figures and tables highlight key points, and multiple case studies in each section provide specific examples of the clinical application of each pulmonary function test. This is an ideal guide to pulmonary function tests for practicing pulmonologists, residents, fellows, and medical students.
Download or read book Lung Function Testing written by R. Gosselink and published by European Respiratory Society. This book was released on 2005-04-01 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although diagnosis always begins with a careful history and physical examination and a physician is obligated to consider more than the diseased organ, testing of lung function has become standard practice to confirm the diagnosis, evaluate the severity of respiratory impairment, assess the therapy response and follow-up patients with various cardio-respiratory disorders. Ventilation, diffusion, blood flow and control of breathing are the major components of respiration and one or more of these functional components can be affected by any disorder. Frequently, no single pulmonary function test.
Download or read book Applied Physiology in Intensive Care Medicine 1 written by Michael R. Pinsky and published by Springer Science & Business Media. This book was released on 2013-05-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two previous editions of Applied Physiology in Intensive Care Medicine proved extremely successful, and the book has now been revised and split into two volumes to enhance ease of use. This first volume comprises three elements -- "physiological notes," “technical notes,” and seminal studies. The physiological notes concisely and clearly capture the essence of the physiological perspectives underpinning our understanding of disease and response to therapy. The technical notes then succinctly explain some of the basics of “how to” in this technology-centered field of critical care medicine. Finally, a number of seminal studies are provided on diverse topics in intensive care. Applied Physiology in Intensive Care, written by some of the most renowned experts in the field, is an up-to-date compendium of practical bedside knowledge that will serve the clinician as an invaluable reference source on key issues regularly confronted in everyday practice.
Download or read book Oxford Textbook of Cardiothoracic Anaesthesia written by R. Peter Alston and published by Oxford Textbook in Anaesthesia. This book was released on 2015 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Oxford Textbooks in Anaesthesia series, this title covers the anatomy and physiology, pharmacology, post-operative complications, critical care, and all clinical aspects of cardiac and thoracic anaesthesia. Practical aspects, such as team working, and designing and equipping cardiothoracic theatre and critical care, are also included. The expert and international author team use their experience to ensure this title reflects current world-wide practice across the globe.
Download or read book Cardiopulmonary Monitoring written by Sheldon Magder and published by Springer Nature. This book was released on 2021-09-01 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of the basic physiology of the cardiac and pulmonary systems, tools for cardiopulmonary monitoring, and related issues in the management of specific conditions. The volume is divided into three main parts. The first part examines the functional basis of normal and abnormal physiology, organized into cardiac and pulmonary units and followed by a “combined” interactive component. The next section discusses cardiopulmonary monitoring tools and variables and is also divided into cardiac (e.g, echocardiography, heart rate, cardiac output), pulmonary (e.g, lung volume, pleural pressure, electrical impedance tomography), and combined tools such as radiology/MRI and tissue perfusion tests. The third section concerns the management and application of specific clinical problems such as pulmonary hypertension, cardiac shunts, cardiogenic shock, and ECMO with an emphasis on the physiological basics. /div Cardiopulmonary Monitoring: Basic Physiology, Tools, and Bedside Management for the Critically Ill is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, critical care, emergency medicine, anesthesiology, and radiology.
Download or read book Biotechniques Theory Practice written by S. V. S. Rana and published by Rastogi Publications. This book was released on 2008 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxygen Transfer from Atmosphere to Tissues written by Noberto C. Gonzalez and published by Springer. This book was released on 2012-03-22 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mud Muscle and Miracles written by C. A. Bartholomew and published by Naval Historical Center. This book was released on 1990 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Practical Handbook of Thoracic Anesthesia written by Philip M. Hartigan and published by Springer Science & Business Media. This book was released on 2012-01-07 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook delivers “bottom line,” evidence-based guidance in the practice of thoracic anesthesia. Chapters are short and practical and include actionable technical pearls not available elsewhere. The editor and contributors are academic faculty who work at one of the busiest thoracic surgical programs in North America, and their aim has been to integrate essential concepts with practical decision-making. •Detailed guidance for performing more than 30 thoracic surgical procedures •Relevant surgical insights from a senior thoracic surgeon included for each procedure •Full range of modern thoracic anesthetic challenges covered •Essential foundation concepts digested and simplified •Technical aspects sufficiently detailed to be useful •An efficient resource for skilled generalists and trainees
Download or read book The Radio Amateur s Hand Book written by A. Frederick Collins and published by anboco. This book was released on 2016-08-13 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Before delving into the mysteries of receiving and sending messages without wires, a word as to the history of the art and its present day applications may be of service. While popular interest in the subject has gone forward by leaps and bounds within the last two or three years, it has been a matter of scientific experiment for more than a quarter of a century. The wireless telegraph was invented by William Marconi, at Bologna, Italy, in 1896, and in his first experiments he sent dot and dash signals to a distance of 200 or 300 feet. The wireless telephone was invented by the author of this book at Narberth, Penn., in 1899, and in his first experiments the human voice was transmitted to a distance of three blocks. The first vital experiments that led up to the invention of the wireless telegraph were made by Heinrich Hertz, of Germany, in 1888 when he showed that the spark of an induction coil set up electric oscillations in an open circuit, and that the energy of these waves was, in turn, sent out in the form of electric waves. He also showed how they could be received at a distance by means of a ring detector, which he called a resonator.
Download or read book Coffee and Caffeine Consumption for Human Health written by Juan Del Coso and published by MDPI. This book was released on 2020-04-15 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2019 has been prolific in terms of new evidence regarding the effects of coffee and caffeine consumption on diverse aspects of human functioning. This book collects 20 high-quality manuscripts published in Nutrients that include original investigation or systematic review studies of the effects of caffeine intake on human performance and health. The diversity of the articles published in this Special Issue highlights the extent of the effects of coffee and caffeine on human functioning, while underpinning the positive nature of most of these effects. This book will help with understanding why the natural sources of caffeine are so widely present in the nutrition behaviors of modern society.