Download or read book The Molecular Vision of Life written by Lily E. Kay and published by Oxford University Press, USA. This book was released on 1993 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating study examines the rise of American molecular biology to disciplinary dominance, focusing on the period between 1930 and the elucidation of DNA structure in the mid 1950s. Research undertaken during this period, with its focus on genetic structure and function, endowed scientists with then unprecedented power over life. By viewing the new biology as both a scientific and cultural enterprise, Lily E. Kay shows that the growth of molecular biology was a result of systematic efforts by key scientists and their sponsors to direct the development of biological research toward a shared vision of science and society. She analyzes the motivations and mechanisms empowering this vision by focusing on two key institutions: Caltech and its sponsor, the Rockefeller Foundation. Her study explores a number of vital, sometimes controversial topics, among them the role of private power centers in shaping scientific agenda, and the political dimensions of "pure" research. It also advances a sobering argument: the cognitive and social groundwork for genetic engineering and human genome projects was laid by the American architects of molecular biology during these early decades of the project. This book will be of interest to molecular biologists, historians, sociologists, and the general reader alike.
Download or read book Membranes to Molecular Machines written by Mathias Grote and published by University of Chicago Press. This book was released on 2019-07-09 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher. The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Award for his contribution to the development of optogenetics.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A History of Molecular Biology written by Michel Morange and published by Harvard University Press. This book was released on 2000 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.
Download or read book The Black Box of Biology written by Michel Morange and published by Harvard University Press. This book was released on 2020-06-09 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.
Download or read book The Molecularisation of Security written by Christopher Long and published by Routledge. This book was released on 2021-09-23 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the way that the molecular sciences are shaping contemporary security practices in relation to the governance of biological threats. In response to biological threats, such as pandemics and bioterrorism, governments around the world have developed a range of new security technologies, called medical countermeasures, to protect their populations. This book argues that the molecular sciences’ influence has been so great that security practices have been molecularised. Focusing on the actions of international organisations and governments in the past two decades, this book identifies two contrasting conceptions of the nature or inherent workings of molecular life as driving this turn. On the one hand, political notions of insecurity have been shaped by the contingent or random nature of molecular life. On the other, the identification of molecular life’s constant biological dynamics supports and makes possible the development and stockpiling of effective medical countermeasures. This study is one of the few to take seriously the conceptual implications that the detailed empirical workings of biotechnology have on security practices today. This book will be of much interest to students of security studies, bio-politics, life sciences, global governance, and International Relations in general.
Download or read book Who Wrote the Book of Life written by Lily E. Kay and published by Stanford University Press. This book was released on 2000 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technologyand consequently as a book of life. This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the book of life metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s). Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic book of life.
Download or read book The Molecular Switch written by Rob Phillips and published by Princeton University Press. This book was released on 2020-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.
Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Download or read book Molecular Feminisms written by Deboleena Roy and published by University of Washington Press. This book was released on 2018-11-10 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: �Should feminists clone?� �What do neurons think about?� �How can we learn from bacterial writing?� These provocative questions have haunted neuroscientist and molecular biologist Deboleena Roy since her early days of research when she was conducting experiments on an in vitro cell line using molecular biology techniques. An expert natural scientist as well as an intrepid feminist theorist, Roy takes seriously the expressive capabilities of biological �objects��such as bacteria and other human, nonhuman, organic, and inorganic actants�in order to better understand processes of becoming. She also suggests that renewed interest in matter and materiality in feminist theory must be accompanied by new feminist approaches that work with the everyday, nitty-gritty research methods and techniques in the natural sciences. By practicing science as feminism at the lab bench, Roy creates an interdisciplinary conversation between molecular biology, Deleuzian philosophies, science and technology studies, feminist theory, posthumanism, and postcolonial and decolonial studies. In Molecular Feminisms she brings insights from feminist and cultural theory together with lessons learned from the capabilities and techniques of bacteria, subcloning, and synthetic biology to o er tools for how we might approach nature anew. In the process she demonstrates that learning how to see the world around us is also always about learning how to encounter that world.
Download or read book Oxygen written by Nick Lane and published by Oxford University Press, USA. This book was released on 2002 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.
Download or read book Introduction to Molecular Biology Genomics and Proteomics for Biomedical Engineers written by Robert B. Northrop and published by CRC Press. This book was released on 2008-10-28 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrates the Complex Biochemical Relations that Permit Life to ExistIt can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to
Download or read book Pandemics Pills and Politics written by Stefan Elbe and published by JHU Press. This book was released on 2018-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encapsulating security : pharmaceutical defenses against biological danger -- Discovering a virus's achilles heel : flu fighting at molecular scale -- The pill always wins: Gilead Sciences, Roche and the birth of Tamiflu -- What a difference a day makes : the margin call for regulatory agencies -- Virtual blockbuster : bird flu and the pandemic of preparedness planning -- In the eye of the storm : global access, generics and intellectual property -- 'Ode to Tamiflu' : side effects, teenage 'suicides' and corporate liabilities -- Data backlash : Roche and Cochrane square up over clinical trial data -- 'To boldly go ... ' : pharmaceutical enterprises and global health security -- Epilogue : pharmaceuticals, security and molecular life
Download or read book The Optics of Life written by Sönke Johnsen and published by Princeton University Press. This book was released on 2012-01-19 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optics—a field of physics focusing on the study of light—is also central to many areas of biology, including vision, ecology, botany, animal behavior, neurobiology, and molecular biology. The Optics of Life introduces the fundamentals of optics to biologists and nonphysicists, giving them the tools they need to successfully incorporate optical measurements and principles into their research. Sönke Johnsen starts with the basics, describing the properties of light and the units and geometry of measurement. He then explores how light is created and propagates and how it interacts with matter, covering topics such as absorption, scattering, fluorescence, and polarization. Johnsen also provides a tutorial on how to measure light as well as an informative discussion of quantum mechanics. The Optics of Life features a host of examples drawn from nature and everyday life, and several appendixes that offer further practical guidance for researchers. This concise book uses a minimum of equations and jargon, explaining the basic physics of light in a succinct and lively manner. It is the essential primer for working biologists and for anyone seeking an accessible introduction to optics.
Download or read book Private Science written by Arnold Thackray and published by University of Pennsylvania Press. This book was released on 1998-01-29 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Private Science is a contribution to that debate, focusing particularly on the relationships among corporations, universities, and national governments involved in biotechnological research.
Download or read book The Story of the Rockefeller Foundation written by Raymond B. Fosdick and published by Routledge. This book was released on 2017-09-29 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its original publication in 1952, Fosdick's book has been the single most reliable treatment of one of the most important philanthropies in the United States and indeed the world. Fosdick served as president of the foundation for twelve years, from 1936 to 1948, when it was the largest grant-making endow-ment in the world. As Steven Wheatley notes in his valuable new introduction, in part The Story of the Rockefeller Foundation was intended as an instrument of institutional self-defense. When it was written, the foundation community was under mounting political attack from the right, and the book was meant to help balance the Scales by cataloging the foundation's good works. As a deliberate self-portrait, the book conceals as much as it reveals, while in the process it reveals a good deal about the author. Fosdick sees politics, like bureaucracy, as perhaps an avoidable problem and not an inevitable consequence of foundation activity. He sees foundations as engaging in the application of scientific, tech-nical, and organizational solutions to public problems through a ""venture cap-ital"" approach to discovering how to resolve them. Fosdick's ""higher ground"" approach became established philanthropic practice far beyond the Rockefeller Foundation. Consequently, this volume is significant as an institutional history as well as a charter for American foundations.
Download or read book Molecular Biology of Cancer written by Lauren Pecorino and published by Oxford University Press, USA. This book was released on 2012-04-26 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
