Download or read book The Illustrated Dictionary of Toxicologic Pathology and Safety Science written by Pritam S. Sahota and published by CRC Press. This book was released on 2019-04-26 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Download or read book Toxicologic Pathology written by Pritam S. Sahota and published by CRC Press. This book was released on 2024-03-25 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in detecting test article-related adverse effects by characterizing morphologic changes in animal tissues and/or body fluids under prescribed study conditions or less clearly defined conditions in the environment and in the interpretation of these findings relative to human risk. In fact, pathology evaluation is often the single most important decision-making factor in nonclinical safety assessments as 80% of drug candidate attrition has been attributed to pathology findings in toxicity studies. There are currently no primers or basic overviews covering the field of toxicologic pathology, whereas there are at least several basic books that cover the sister field of toxicology. Toxicologic Pathology: A Primer is a practical, easy-to-use reference designed to contain core information provided by board-certified veterinary pathologists, all experts in the field. The Primer contains the basic, underlying principles of toxicologic pathology at the introductory level; thus it will be valuable to the veterinary pathology student who may be considering a career in the field as well as a companion to the seasoned toxicologic pathologist who wants a succinct refresher. The Primer is arranged as chapters presenting each major organ system preceded by an overview chapter covering the field of toxicologic pathology followed by a “concept” chapter describing the role of toxicologic pathology in drug development. Photomicrographs and illustrations provide visual context. The organ system chapters provide histopathologic descriptions of lesions observed in toxicity studies of test articles in drug development and testing of chemicals that may negatively impact the environment. Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk. Each organ system chapter contains: A brief introduction A succinct description of the anatomy and physiology of the system Descriptions of the most important pathological lesions Differential diagnoses Biological consequences, pathogenesis, and/or mechanism of lesion formation Associated clinical pathology correlates Nonclinical safety scientists such as study directors, non-pathology-oriented contributing scientists such as senior toxicology report reviewers, scientific management of Contract Research Organizations (CROs), and students should find the Primer useful in helping them understand the fundamentals of toxicologic pathology.

Download or read book Current Topics in Nonclinical Drug Development written by Philip Bentley and published by CRC Press. This book was released on 2023-11-03 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, study directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Download or read book Current Topics in Nonclinical Drug Development written by Pritam S. Sahota and published by CRC Press. This book was released on 2020-12-23 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Download or read book Road to Greatness written by Pritam S. Sahota Donald A. Assmann Mary Arnella-Venezia Michael Rubell Gulzar S. Sandhu Zbigniew W. Wojcinski and published by Page Publishing Inc. This book was released on 2022-04-08 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Greatness” has been defined as a quality of being great, distinguished, or eminent. “Road to Greatness” employs examples of selected individuals who achieved greatness. The road begins with a desire to become successful by creating a personal path to attain exceptional goals. “Genius= 1% Inspiration and 99% Perspiration.” - Thomas Edison (Inventor: He made 1000 unsuccessful attempts before inventing the light bulb.) “Never, never, never, never give up.” – Sir Winston Churchill (Historian, Nobel Prize Winner in Literature (1953) and Prime Minister of the UK during World War-2.) “A person who never made a mistake never tried anything new.” – Albert Einstein (Theoretical physicist; Winner of the 1921 Nobel Prize in Physics.) “If you can dream it, you can do it.” – Walt Disney (Entrepreneur, animator, writer, film producer; record holder for individual Academy Awards.) “People do not decide to become extraordinary. They decide to accomplish extraordinary things.” Sir Edmund Hillary (Mountaineer, explorer, philanthropist; first climber with Tenzing Norgay to summit Mount Everest in 1953). “Road to Greatness” explores four groupings of over forty success factors that are instrumental in extraordinary achievement: Physical and Mental Fitness Connection of Inner and Outer Circles Constant Learning Skill Development Achieving competence in the success factors enhances an individual’s ability to achieve greatness and can be developed through discipline and deliberate practice by incorporation in small increments into routine activities. True greats consistently grow through self-awareness to overcome their limitations, take on challenges, and endeavor to face the obstacles they encounter. The characteristics and traits that drive greatness are inherent within all of us and can be applied to any field, subject, or discipline. “Road to Greatness” provides a roadmap to create a personalized path to extraordinary achievement for students, parents, teachers and graduates entering the workforce. Although it is uncertain what challenges you will face, the roadmap and exploration of greatness arms you with the tools you will need. As such, only one question remains: Are you willing to embark on your own road to greatness?

Download or read book Nanotechnology Applications for Cancer Chemotherapy written by Sanyog Jain and published by Elsevier. This book was released on 2020-09-30 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics. - Discusses how organic and inorganic nanoplatforms are being used in cancer treatment - Shows how nanotechnology is being used to create new and more accurate diagnostic tools - Surveys the current generation of cancer nanomedicines, assessing their advantages and challenges

Download or read book Hayes Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Download or read book Dictionary of Toxicology written by Ernest Hodgson and published by Nature Publishing Group. This book was released on 1998-01-01 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 4,000 insightful definitions, Dictionary of Toxicology is the only book to bring together in one place the language of toxicology. This edition contains 40% new material in areas such as molecular, environmental and regulatory toxicology. In addition, one third of the first edition entries have been revised. A new comprehensive subject area index guides users to all entries pertinent to particular topical areas. Ideal for those studying and/or working in toxicology, pharmacology, medicine, biotechnology, R&D in industry, government and science policy.

Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2017-08-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. - Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work - Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence - Teaches biomedical researchers to examine the histologic changes in their model rodents - Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Download or read book Black s Veterinary Dictionary written by Edward Boden and published by Bloomsbury Publishing. This book was released on 2015-03-26 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Black's Veterinary Dictionary has been a bestseller for over 80 years. It is an essential reference tool for all with a professional or leisure interest in the care of animals. Much more than a list of veterinary terms, its practical approach ensures that readers gain an insight into the signs and symptoms of common, and less common, diseases, their diagnosis and treatment. For the 22nd edition much new and updated information has been included, reflecting the numerous developments that have taken place in animal care and husbandry, and welfare. There is greatly expanded coverage of topics relating to popular breeds of dog and cat, and the inheritable conditions that might affect their health. Advances in medicine, surgery and diagnostic techniques; descriptions of newly identified diseases such as Schmallenberg virus; the resurgence of old scourges such as TB in cattle, and ongoing enzootic infections such as bird flu are included in this new edition. The growing risk of exotic diseases such as heartworm being imported following the relaxation of travel arrangements for dogs and cats is reflected in new entries. Notes on many new species being farmed or kept as companion animals are among the thousands of topics covered. Whether your interest is in cats or cattle, horses or hamsters, puppies or pigeons, the A-Z of veterinary matters is covered in Black's Veterinary Dictionary.

Download or read book Current Topics in Nonclinical Drug Development written by Pritam S. Sahota and published by CRC Press. This book was released on 2023-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development"--

Download or read book Wheater s Basic Pathology A Text Atlas and Review of Histopathology E Book written by Barbara Young and published by Elsevier Health Sciences. This book was released on 2009-12-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wheater's Basic Pathology: A Text, Atlas and Review of Histopathology, 5th Edition, by Barbara Young, BSc, Med Sci(Hons), PhD, MB, BChir, MRCP, FRCPA, Geraldine O'Dowd, BSc(Hons), MBChB(Hons), FRCPath and William Stewart, BSc (Hons), MBChB, PhD, DipFMS, FRCPath is a pathology resource that offers a comprehensive introduction to the subject first by covering fundamental pathological processes and then addressing the common diseases encountered in systems pathology. Hundreds of high-quality images illustrate the essential features of pathology and make it easy to make definitive comparisons to your own lab samples, while concise captions enable you to quickly and easily understand key points. Wheater's Basic Pathology is an excellent companion resource for users of Wheater's Functional Histology, Wheater's Review of Histology, and Basic Pathology, or Robbins and Cotran Pathology Flash Cards. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Offers discussions of basic pathological processes as well as coverage of common diseases encountered in systems pathology for a complete review. Includes comprehensive updates, with relevant molecular pathology issues explained in the context of the clinical presentation, the treatment implications, and the underlying pathological processes Presents nearly 650 images of the highest quality that vividly and clearly illustrate the essential features of pathology and enable you to make definitive comparisons to your own lab views. Features concise text that distills basic and complex information into a coherent explanation to help you understand key points quickly and easily. Provides keys to the lettering in images at the bottom of each page, saving you time in reviewing figures. Serves as a companion text to Wheater’s Functional Histology, 5th Edition, offering a comparison of normal histology with the pathological changes in disease. Features a short review section at the end of each chapter covering the key point of the chapter in brief form for the perfect pairing of reference and review. Includes online access to Student Consult where you'll find the complete text and illustrations from the book, fully searchable • and additional USMLE-style questions for self assessment Provides additional colored text boxes with clinical-pathological correlations that explain the relevance of the pathological processes underlying common diseases and their complications. FOR FACULTY Features online access to Evolve Resources including a high-resolution image bank with all the illustrations, figures and tables from the book, and a test bank.

Download or read book Toxicologic Pathology written by Pritam S. Sahota and published by CRC Press. This book was released on 2013-04-09 with total page 987 pages. Available in PDF, EPUB and Kindle. Book excerpt: As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Saf

Download or read book Saunders Comprehensive Veterinary Dictionary E Book written by Virginia P. Studdert and published by Elsevier Health Sciences. This book was released on 2011-12-09 with total page 1340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Blood’s classic Comprehensive Veterinary Dictionary has been completely redesigned, revised and updated for today’s veterinary team. Now with a wide range of superb full-colour illustrations, well over 60,000 main and subentries including large animals, small animals and exotics, and an all-new, user-friendly format, the fourth edition offers the most comprehensive dictionary reference in the field. Comprehensive text covering the whole range of veterinary medicine Classic authoritative reference work Valuable and accessible appendices for instant access to key information at a glance Well over 60,000 main entries and subentries Extensive contributions from internationally acknowledged expert consultants New for this edition Over 1,000 colour illustrations to aid further understanding of disease processes and important terminology Pronunciation of key terms Brand new design and format to help find key information at a glance Extensive revision, clarification and focussing of entries to reflect current practice

Download or read book Veterinary Forensic Pathology Volume 1 written by Jason W. Brooks and published by Springer. This book was released on 2018-02-07 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated two-volume book offers a comprehensive and essential reference guide for veterinary pathologists and clinical veterinarians interested in performing animal necropsies for forensic casework. It presents a broad range of animal crime cases, with particular focus on the post mortem examination and the observed pathology. This first volume introduces readers to veterinary forensics and the role of the veterinary pathologist in animal crime investigations. It guides them through the process of evidence collection and documentation, and covers the fundamentals of forensic necropsy and the estimation of time since death. In-depth descriptions of how to conduct the forensic evaluation of various traumatic injuries, firearm injuries, and asphyxia are also provided.

Download or read book The Role of the Study Director in Nonclinical Studies written by William J. Brock and published by John Wiley & Sons. This book was released on 2014-06-03 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

Download or read book Pathologic Basis of Veterinary Disease E Book written by James F. Zachary and published by Elsevier Health Sciences. This book was released on 2011-06-01 with total page 1339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathologic Basis of Veterinary Disease - E-Book