Download or read book The Hypothalamic Pituitary Adrenal Axis in Health and Disease written by Eliza B. Geer and published by Springer. This book was released on 2016-12-01 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cushing ́s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Download or read book The Hypothalamus Pituitary Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
Download or read book Clinical Neuroendocrinology written by Michael Wilkinson and published by Cambridge University Press. This book was released on 2019-01-03 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
Download or read book The Hypothalamic pituitary adrenal Axis written by Alan F. Schatzberg and published by . This book was released on 1988 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anxiety Disorders written by Kerry Ressler and published by Oxford University Press. This book was released on 2015-04-15 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anxiety affects millions, manifesting as generalized anxiety disorder (GAD), obsessive compulsive disorder, panic disorder, phobias, post-traumatic-stress disorder (PTSD), and social anxiety disorder. Not only are anxiety disorders common, but they are also crippling, frequently co-occurring and predict high risk for depressive disorders. Shared mechanisms may explain the overlapping features of many anxiety disorders and account for associations with other highly-impairing conditions, such as major depression and substance use. Beyond risk for specific disorders, anxiety also predicts a number of other adverse outcomes, including suicidal behavior, medical problems, social, and economic difficulties. Conversely, disorder-specific mechanisms may also exist and explain the unique features of each syndrome. Thus, it is important to understand both shared and specific aspects of anxiety. The Primer on Anxiety Disorders provides early-stage practitioners and trainees, as well as seasoned clinicians and researchers, with need-to-know knowledge on diagnosis and treatment. Clinical cases are used throughout the book to enhance understanding of and illustrate specific disorders, comorbid conditions and clinical issues. To facilitate an integrative approach, content allows clinicians to understand patient characteristics and tailor interventions. The integrated approach of each chapter includes recent research on genetics and neuroscience to understand the mechanisms of anxiety disorders, focusing on the forthcoming new nosology in DSM-5. Chapters further integrate innovative advances in clinical research providing research on a range of discoveries regarding biomarkers of illness, biological predictors of treatments and the effect of treatment on neurocircuitry.
Download or read book Functional Somatic Symptoms in Children and Adolescents written by Kasia Kozlowska and published by Springer Nature. This book was released on 2020-09-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.
Download or read book ACTH Action in the Adrenal Cortex From Molecular Biology to Pathophysiology written by Nicole Gallo-Payet and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.
Download or read book Cellular Endocrinology in Health and Disease written by Alfredo Ulloa-Aguirre and published by Academic Press. This book was released on 2021-02-19 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Download or read book Neuroendocrinology in Physiology and Medicine written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 1999-10-06 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.
Download or read book Pituitary rhythms in health and disease written by Gerrit van den Berg and published by . This book was released on 2000 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Download or read book Adrenalogic Outsmarting Stress written by Lena Edwards and published by eBookIt.com. This book was released on 2012-07-10 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today's society most of us are move at a rapid pace and have taken on more responsibilities than ever before. In turn, this has caused a surge in stress levels. If you are among the millions who deal with the consequences of chronic stress including: exhaustion, chronic fatigue, weight gain and depression, Dr. Lena Edwards can help.Dr. Edwards is a highly respected internist who is also Board Certified and Fellowship Trained in Functional and Regenerative Medicine. In this vital book, Dr. Edwards dispels modern myths surrounding stress, offers logical, clear health advice and explains the critical role that adrenal glands play in the stress process.Giving stress the credibility and the attention it deserves, Dr. Edwards explains the link between the hormones, stress levels and the development of disease – a health connection that has not yet been fully realized. If you're looking for clear answers, you'll find this book packed with real-life case studies, graphics and the most current facts on the inter-connection between stress, abnormal cortisol production and pervasive modern maladies such as: cancer, heart disease, depression, allergies, insomnia, reproductive disorders, and premature aging.Readers of Adrenalogic have the opportunity to 'step behind the curtain' and discover the intricate relationship between mind and body while Dr. Edwards carefully explains the steps needed to regain health and balance and provides insight into the ways that you can out-smart stress and prevent it from interfering with your daily life.
Download or read book The Hypothalamus and Pituitary in Health and Disease written by William Locke and published by Charles C. Thomas Publisher. This book was released on 1972 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glucocorticoid sensitivity in health and disease written by Christopher Allan Barton and published by . This book was released on 1999 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study which examines whether alterations in the activity of the hypothalamic-pituitary-adrenal axis (HPA-axis) in subjects with chronic post-traumatic stress disorder (PTSD), are fundamental to the development of the disorder, or whether they arise once the condition is established. Results suggest that different neurosteroids may mediate different components of the psychological reponse to a traumatic event. Dysregulation of these neuroendocrine systems may be important in the consolidation of adverse psychological reactions to the trauma that take place in the first month after the event, and may lead to the development of PTSD.
Download or read book Mental Health Diabetes and Endocrinology written by Anne M. Doherty and published by RCPsych Publications. This book was released on 2021-10-28 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental Health, Diabetes and Endocrinology examines the main areas of clinical overlap between endocrinology and mental health to address key clinical conundrums. Drawing on the most recent developments from literature and clinical practice, this book gives specific attention to the main areas where clinical conundrums and treatment challenges arise across endocrinology, psychiatry, psychology and primary care. Common challenges in this area include depression which can impact on the person's ability to self-care and to adhere to treatment with consequences for their morbidity and mortality; 'diabulaemia' associated with high mortality rates; obesity and associated mental disorders; cognitive impairment and mental capacity; anti-psychotic medications and their endocrine sequelae; and specific setting-related considerations. Mental Health, Diabetes and Endocrinology is a useful resource for the overlapping conditions across these specialities, and provides clinically-focussed evidence-based resources for all health care professionals who encounter these issues.
Download or read book Psychosocial Stress Hypothalamic Pituitary Adrenal HPA Axis Function and Cardiometabolic Health written by Henry Matthew Lehrer and published by . This book was released on 2019 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation examines the contribution of various psychological and social stressors to indicators of cardiovascular and metabolic function and disease. It also investigates the role of altered hypothalamic pituitary adrenal (HPA) axis activity as a mechanism by which psychosocial stress may influence cardiometabolic health. Grounded in the framework of the allostatic load model, studies 1-3 build on each other to assess the interplay between various types of stress, HPA axis indicators, and cardiometabolic health outcomes among diverse populations. Study 1 examines the association of perceived everyday discrimination and hair cortisol concentration, a stable indicator of retrospective cortisol output indexed over several months. The analyses focus on racial group differences, finding that perceived discrimination scores were associated with elevated hair cortisol concentration for African American adults but not White adults. Given that both groups reported similar discrimination frequency scores, this finding suggests that more qualitative characteristics of discrimination may be particularly salient to HPA axis output among African Americans. Study 2 moves one step past the stress-HPA axis association by examining the role that elevated HPA axis activity plays in the association between perceived stress and metabolic syndrome severity. This study found that psychological resilience protected against the association of elevated perceived stress with increased metabolic syndrome severity via elevated hair cortisol concentration. Study 3 uses the same resilience-based framework as study 2, but does so in a national longitudinal cohort of U.S. adults. Using daily diary entries and salivary cortisol analysis, this study examines unique effects of daily stressor frequency and severity on cardiovascular and metabolic disease prevalence 5-8 years later. Study 3 also tests whether flattened diurnal salivary cortisol slopes mediator effects of stressor frequency and severity on cardiometabolic conditions, and examines a latent resilience resources variable as a potential buffer of the daily stress-cardiometabolic disease relationship. Findings indicate that greater perceived stressor severity and flattened diurnal cortisol slopes predict greater cardiometabolic disease prevalence later in life. Taken together, this collection of studies provides evidence supporting the contribution of greater psychosocial stress to impaired cardiovascular and metabolic health, and suggests that the HPA axis plays a significant role
