Download or read book The Fischer Indole Synthesis written by Brian Robinson and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Fischer Indole Synthesis written by Brian Robinson and published by . This book was released on 1982 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of the Fischer indole synthesis. Emphasizes three main features of the reaction, its development, the clarification of its mechanism, and the utilization of it and its extensions in the synthetic process. Covers the investigations of the reaction from its discovery in 1883 through the last published report in 1981.
Download or read book Indole Ring Synthesis written by Gordon W. Gribble and published by John Wiley & Sons. This book was released on 2016-08-08 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Download or read book Organic Chemistry 100 Must Know Mechanisms written by Roman Valiulin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-04-20 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes 100 essential mechanisms in organic chemistry ranging from classical such as the Reformatsky Reaction from 1887 to recently elucidated mechanism such as the copper(I)-catalyzed alkyne-azide cycloaddition. The reactions are easy to grasp, well-illustrated and underpinned with explanations and additional information.
Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2007-02-16 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Download or read book Indoles written by Richard J. Sundberg and published by Elsevier. This book was released on 1996-05-28 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. - Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors - Discusses methods for preparing indoles by annelation of pyrroles - Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles - Considers use of cycloaddition reactions for synthetic elaboration of indoles
Download or read book Studies on the Fischer Indole Synthesis written by Earl Eugene Fisher and published by . This book was released on 1948 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Chemistry of Indoles written by Richard Sundberg and published by Elsevier. This book was released on 2012-12-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry, Volume 18: The Chemistry of Indoles discusses the chemistry of indole derivatives. This book explores the potent biological activity of several indole derivatives and explains the structure of indole alkaloids. Organized into 10 chapters, this monograph starts with an overview of the most important types of reactions of the indole ring on a mechanical basis. This text then proceeds to review the methods of synthesizing indoles and describes the oxidations and rearrangements of indole derivatives. Other chapters explore the special features of the synthesis and reactivity of hydroxyindoles, acylindoles, and aminoindoles. This book discusses as well the properties of carboxyl groups, which is substituted on the benzenoid ring of the indole nucleus that is typical of aromatic carboxylic acids. The final chapter deals with the certain classes of indoles that are found in nature. Chemists, researchers, and readers interested in the chemistry of indoles will find this book extremely useful.
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Download or read book II Studies on the Fischer Indole Synthesis written by John George Wallace and published by . This book was released on 1950 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kinetic Investigations of the Fischer Indole Synthesis written by Paulus Isaac Theodoor Scheltus and published by . This book was released on 1959 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Name Reactions in Heterocyclic Chemistry written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2004-12-27 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike.
Download or read book Kinetic Investigations of the Fischer Indole Synthesis written by Paulus Isaac Th.. Scheltus and published by . This book was released on 1959 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Study of the Fischer Indole Synthesis written by Frank P. Robinson (Jr.) and published by . This book was released on 1964 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aim of gaining evidence in support of the proposed dienone-imine intermediate in the Fischer indole synthesis, several attempts were made to form a Diels-Alder adduct of this intermediate by the thermal cyclization of simple phenylhydrazones in the presence of the dienophiles, maleic anhydride and tetracyanoethylene. Even though cyclization of the phenylhydrazones to the corresponding indoles occurred under the conditions used, no adduct could be isolated. With maleic anhydride as the dienophile, hydrazide formation occurred instead. Attempts to form such an adduct by cyclizing the diacetyl derivative of methyl ethyl ketone phenylhydrazone in the presence of maleic anhydride were also unsuccessful. The attempted preparation of the diacetyl derivatives of 2,6-dimethylphenylhydrazones led to mono- and di-acylated 2,6-dimethylphenylhydrazines instead. An improved technique for the identification of these latter compounds was devised. This method consists of hydrogenolysis of the N-N bond of the acylated hydrazines with Raney nickel and hydrazine, followed by isolation and identification of the resulting fragments. Finally, when N'-methyl-2,6-dicholorophenylhydrazine was prepared and condensed with cyclohexanone under mild room temperature conditions, two indoles were isolated and their structures proven by unambiguous syntheses. The formation of these products is explained in terms of the proposed dienone-imine intermediate. This also represents the first known case of such a facile non-catalytic Fischer indole synthesis.
Download or read book Towards an Efficient Fischer Indole Synthesis of 3 2 biindoles written by Joseph K. Kubert and published by . This book was released on 2010 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reactive Intermediates in the Fischer Indole Synthesis written by Dorothy M. Walker and published by . This book was released on 1967 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Heterocyclic Chemistry II written by Alan R. Katritzky and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
