Download or read book The Effects of Fish Oil EPA DHA on Chronic Ventilator Patients in a Long Term Acute Care Setting written by Jessica C. Harvey and published by . This book was released on 2011 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: The aim of this study was to determine whether patients in a long term acute care setting who received an enteral supplement containing EPA+DHA, would have a shorter weaning time from the ventilator, a decrease in length of hospital stay, decreased inflammatory markers, and number of infections from baseline to post-treatment compared to patients who received a placebo of normal saline solution. Methods: Nine participants who required mechanical ventilation and enteral nutrition support in a long term acute care hospital were randomized to either receive the treatment fish oil (n=5) or the placebo saline solution (n=4). Participants in the treatment group were given 8g fish oil per day through the enteral feeding tube for 14 days. Subjects randomized to the control group received a blinded saline solution for 14 days. All enteral supplement formulations were createdby a certified pharmacist. Results: There were no significant differences between the treatment and control groups in regards to time to weaning, percent of days on the ventilator, or length of hospital stay. Inflammatory markers did not significantly decrease in either group from baseline to posttreatment. There was a trend towards a lower rate of infection in the treatment group compared to the control group, however these results were not significant. Conclusion: The results of this randomized double blind clinical trial suggest that adding fish oil(EPA/DHA) to enteral formulas does not result in reduced weaning time for patients on a ventilator, decreased length of hospital stay, or markers of inflammation. Additional researchneeds to be conducted with a larger group of participants to determine whether a high dose of EPA +DHA from fish oil can decrease inflammation in this specific population.
Download or read book The Feasibility of a Randomized Controlled Trial Investigating the Effects of Fish Oil Eicosapentaenoic Acid EPA and Docosahexanoic Acid DHA on Chronic Ventilator Patients in a Long Term Acute Care Hospital LTACH Setting written by Keith A. Rosing and published by . This book was released on 2009 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective: Assess the feasibility and efficacy of an ongoing randomized control trial currently in progress at the Drake Center in Cincinnati, Ohio, to determine the effects of EPA + DHA on inflammation, infections, weaning, length of stay and mortality among mechanically ventilated patients in a LTACH setting. Subjects: Thus far, there have been three patients to complete the study. All three were females, two were Caucasian and one was African American. Their ages were 58, 42, and 53. All three were diagnosed with Respiratory Failure, though each one's conditions stemmed from a different initiating event. In addition, the screening results for the first 32 patients screened for study enrollment are presented. Of these patients, 17(53%) were male, 15(47%) were female, and the average age of those patients screened who met the age criteria was 56.1" 5.99. Potential participants were assessed based on five inclusion criteria and eleven exclusion criteria. Overall, a history of ventricular tachycardia or atrial fibrillation was the most commonly indicated reason for exclusion (n=13) followed by a treatment dosage of heparin or coumadin (n=11), and an aPTT>33.5s (n=10). Study Design: Double-blind, randomized, placebo-controlled trial. Methods: Study participants were randomized to either a study group or a placebo control group. Subjects randomized to the study group received 8g of fish oil per day in divided doses administered through enteral tube every 6 hours for 14 days. Saline was administered to those in the control group in the same manner. The primary and secondary measures being investigated in this study include the inflammatory markers IL-6, IL-8, and LTB4, infectious events, weaning, length of stay, and mortality. Results: The study records for the first three patients to complete the trial indicated that the study protocol was followed completely and appropriately. Each of the participants weaned successfully and were eventually discharged, but only one of the participants completed the study. Two dropped out upon experiencing a bad taste or bad odor that they attributed to the study medication even though only one of these participants was actually receiving fish oil. Analysis of the screening results indicated that among the males and females screened for study enrollment, males were excluded more often than females mostly due to a greater likelihood of having a history of ventricular tachycardia or ventricular fibrillation. Conclusion: The results of this feasibility study suggest that the trial is going well and according to the research methodology mapped out previously by the researchers. There were a couple of areas that were identified as being of potential concern. These include the variation in initiating events observed among the first three participants, an all female enrollment, the enrollment of patients with a recent or current infection, and the significance of participant complaints concerning the taste/odor of the study medication.
Download or read book Fish Oil written by Joseph C. Maroon and published by Basic Health Publications, Inc.. This book was released on 2006 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammation can cause chronic pain, a breakdown of cartilage and muscle, increased blood clotting, and may cause genetic changes leading to various cancers. This book discusses a method of mitigating the effects of chronic inflammation through the power of fish oil.
Download or read book The Effect of Omega 3 Fatty Acids on Airway Inflammation Hyperpnea induced Bronchoconstriction and Airway Smooth Muscle Contractility in Asthma written by Sally K. Head and published by . This book was released on 2011 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication of asthma. Although traditionally treated pharmacologically, nutritional strategies provide a promising alternative for managing EIB as the prevalence of asthma may be due in part to changes in diet. Our objective was to determine the effects of novel nutritional strategies on hyperpnea-induced bronchoconstriction (HIB) in asthmatic individuals. HIB uses rapid breathing to identify EIB in a research or clinical setting. Fish oil, a combination of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docsahexaenoic acid (DHA), has been shown to be effective in suppressing EIB. However, its use in combination with other nutritional supplements, the optimal fish oil formula, and its effect on smooth muscle contractility have not been fully explored. An in vivo study (study 1) was conducted in individuals with both asthma and HIB to determine whether a combination of fish oil and vitamin C was more effective than either one alone in alleviating HIB. Pulmonary function was significantly improved with both fish oil and the combination treatment but not with vitamin C alone. In study 2, individuals with both asthma and HIB were supplemented with DHA alone since the optimal formula for fish oil has yet to be ascertained; previous in vitro studies have suggested DHA may be the more potent omega-3 fatty acid in fish oil. However, no significant changes in pulmonary function or airway inflammation were seen with DHA supplementation. For study 3, canine airway smooth muscle tissue was treated with fish oil to determine the in vitro effect of fish oil on smooth muscle contractility. Acute treatment with fish oil relaxed smooth muscle strips that had been contracted with 5-hydroxytryptamine. These minor relaxations in smooth muscle tension with fish oil may represent significant changes at the level of the smaller airways. These studies have confirmed that fish oil represents a viable treatment modality for asthmatic individuals with EIB and suggest that fish oil may influence airway smooth muscle contractility.
Download or read book DHA A Good Fat written by James J. Gormley and published by Kensington Books. This book was released on 1999-10-01 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identifying Putative Novel Bioactive Molecules in Fish Oil Supplements written by Al Rijjal Dana and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Fish oil (FO) supplements contain omega-3 fatty acids (u03c9-3 FAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major components to which health benefits of FO are generally attributed. FO supplements enriched with u03c9-3 FAs are prescribed to metabolic syndrome patients with severe hypertriglyceridemia to decrease their triglyceride levels. In contrary to FOu2019s beneficial effect on lipid metabolism, increased FO consumption is associated with an increased risk of Type 2 Diabetes (T2D). We have recently discovered that 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF), a furan fatty acid (FuFA) metabolite, was found to be the major metabolite produced from FO consumption in humans. CMPF along with EPA and DHA are elevated in the serum of Gestational Diabetes Mellitus (GDM) patients. Elevated CMPF levels can cause beta cell dysfunction shown as impaired glucose stimulated insulin secretion (GSIS) in mice. Therefore, whether the effects of EPA and DHA at levels seen in GDM could impair glucose homeostasis and lead to the transition of GDM to T2D is yet to be determined.Aim: The objective of this study is to determine the effects of EPA and DHA on glucose metabolism.Method: Islets isolated from mice were treated with EPA and DHA at low and high doses for 24 hours. GSIS was then performed to determine the effects of EPA and DHA on beta cell function. Animal models will be used to test the effect of EPA and DHA on glucose homeostasis in vivo. Glucose tolerance test will be performed and ex-vivo GSIS will be used to determine the long-term effects of EPA and DHA on beta cell function.Results: In vitro, mouse islets treated with EPA and DHA at lower concentrations had no difference on GSIS. In comparison, higher concentrations of EPA and DHA showed impaired GSIS indicating a dose dependent effect of FO on pancreatic beta cell function.Discussion: The preliminary results indicate an effect of increased levels of EPA and DHA on pancreatic beta cell function that is similar to the effects seen of CMPF. Upon conclusion, this study will provide a new prospective on our current understanding of the effects of fish oil supplements on glucose metabolism.
Download or read book Fish Oil Volume 2 of 2 EasyRead Super Large 24pt Edition written by and published by ReadHowYouWant.com. This book was released on with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DHA docosahexaenoic Acid written by Beth M. Ley and published by Bl Publications. This book was released on 1999 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DHA written by James J. Gormley and published by James J. Gormley. This book was released on 1999 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this breakthrough book for preventive medicine, Gormley, the award-winning editor of "Better Nutrition" magazine and one of America's foremost experts on supplemental nutrition, draws on cutting-edge research from around the world to explain the benefits of DHA and other omega-3 fats. With rich insight and clear language, he traces the evolution of these studies and explains how to make DHA a beneficial part of one's diet.
Download or read book Beneficial Effects of Fish Oil EPA and DHA on the Cardiovascular System written by and published by . This book was released on 2001 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fish Oil Update written by Richard A. Passwater and published by McGraw Hill Professional. This book was released on 1999-02 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Omega 3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ cell Culture Studies written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Missing Wellness Factors EPA and Dha written by Jorn Dyerberg and published by Turner Publishing Company. This book was released on 2012-05-15 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wellness is more than the absence of disease. It's a vital combination of vibrancy, vitality, abundant energy, and extraordinary health. Here, the authors reveal two essential wellness factors which are often missing in people's diets - omega-3 fatty acids EPA and DHA.
Download or read book Beneficial Effects of Fish Oil on Human Brain written by Akhlaq A. Farooqui and published by Springer Science & Business Media. This book was released on 2009-07-14 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming increasingly evident that the deficiency of n-3 fatty acids in diet is not only associated with cardiovascular diseases, but also involved in stroke, epilepsy and other neurological and neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, and peroxisomal diseases. In his newest book, Beneficial Effects of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands on the status and therapeutic importance of n-3 fatty acids (major components of fish oil) and their mediators in normal brain and those with neurodegenerative and neuropsychiatric diseases. Farooqui presents the benefits of n-3 fatty acids on Western diet, which is enriched in n-6 fatty acids (major components of vegetable oil) and may promote the above neurological disorders. The book will present readers with cutting edge and comprehensive information on metabolism and roles of neural membrane n-3 fatty acids.
Download or read book The Omega 3 Connection written by Andrew L. Stoll, M.D. and published by Simon and Schuster. This book was released on 2001-08-09 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years scientists have searched for a "magic bullet" to relieve the pain of depression and other mood disorders -- safe enough for nursing mothers, children with ADHD, and the elderly, without the side effects associated with medicines like Prozac, Zoloft, and lithium. Now the search may finally be over, thanks to the Omega-3 Renewal Plan, introduced here by Andrew L. Stoll, M.D., Director of the Psycho-pharmacology Research Laboratory at Harvard's McLean Hospital. In his groundbreaking research, Stoll found that omega-3 fatty acids, already known for their importance in preventing heart disease, Crohn's disease, rheumatoid arthritis, and cancer, play a crucial role in mental health -- regulating and en-hancing mood, sharpening memory, and even aiding concentration and learning. And these remarkable substances, so essential to our health, are found abundantly in common fish oils and other sources. The bad news is that even though omega-3 fatty acids have played a critical role in our evolutionary past, these extraordinary substances have been depleted by our Western diet and lifestyle, and the resulting nutritional imbalance seems to have led to a sharp rise in heart disease and depression. By contrast, in Japan and other countries where fish consumption is high, both heart disease and depression rates are low. Stoll explains how easily omega-3s can be used up in just a few generations, and how a new mother with depleted omega-3s loses still more to her baby -- a fact that may account for the severe postpartum depression so many women suffer. He documents evidence that a shortage of omega-3s may also play a role in attention deficit-hyperactivity disorder (ADHD) and other learning problems. The good news is that this downward spiral of depletion and depression can finally be reversed. In his revolutionary Omega-3 Renewal Plan, Dr. Stoll presents readers for the first time with all the tools for restoring their natural balance of omega-3 fatty acids, including which foods to eat and how to choose the most effective over-the-counter supplements. Featuring information on how to integrate flaxseed and fish oils into diet and medication plans, and including simple recipes as well as supplement dosages and sources, The Omega-3 Connection offers an entirely new, practical method for improving mental health.
Download or read book Protective Effect of Fish Oil EPA and DHA on the Cardiovascular System written by and published by . This book was released on 2001 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DHA for Optimal Health written by Barbara Meyer and published by MDPI. This book was released on 2018-06-26 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "DHA for Optimal Health" that was published in Nutrients
