Download or read book The Effect of Metallothionein Overexpression on the Transcription of Selected Genes Involved in One carbon Metabolism and Oxidative Stress in NDUFS4 deficient Mouse Tissues written by and published by . This book was released on 2020 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex I deficiency -- NDUFS4 defect -- Leigh syndrome -- Metallothionein overexpression -- Oxidative phosphorylation (OXPHOS) -- One-carbon metabolism -- Mitochondrial disease -- Oxidative stress -- mRNA -- Reverse transcription real-time PCR (RT-qPCR) -- Gene expression regulation -- Mouse brain tissue -- Mouse quadriceps tissue -- Antioxidant therapy -- Kompleks I -defek -- NDUFS4-defek -- Leigh se sindroom -- Metallotioneïen 1- ooruitdrukking -- Oksidatiewe fosforilering (OKSFOS) -- Regstreekse kwantitatiewe omgekeerde transkriptase polimerase kettingreaksie (RTq-PCR) -- Een-koolstof -metabolisme -- Mitochondriale siekte -- Oksidatiewe stres -- Regulering van geenuitdrukking -- Muis-breinweefsel -- Muis-kwadrisepsweefsel.
Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
Download or read book Mitochondria and the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2005-05-05 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.
Download or read book The Case of the Frozen Addicts written by J.W. Langston and published by IOS Press. This book was released on 2013-12-02 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks
Download or read book Leucocytes written by Robert B. Ashman and published by Humana Press. This book was released on 2012-01-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune response is a crucial component of early resistance to infection, and it is now revealing increasing levels of complexity. The ability to modify the genome in vivo, has facilitated understanding of complex interactions between leucocytes and other components of the immune system, and phenotype-driven strategies using chemical mutagenesis have placed another powerful weapon in the armamentarium. In, Leucocytes: Methods and Protocols provides detailed protocols and practical advice on a variety of modern approaches to the study of leucocytes and their products. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Leucocytes: Methods and Protocols seeks to aid scientists in further study into the immune system and leucocytes.
Download or read book Agrochemicals in Soils written by A. Banin and published by Elsevier. This book was released on 2013-10-22 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Agrochemicals in Soils contains selected papers from a joint meeting of the Soil Chemistry, Soil Fertility, and Soil Clay Mineralogy Commissions of the International Society of Soil Science, in Jerusalem, Israel. The book is organized into four parts. Parts 1 and 2 deal mostly with the chemical reactions of agrochemicals in the soil. Part 3 explores the movement of agrochemicals in the soil and Part 4 elucidates some aspects of agrochemicals and pollution. Each section begins by one or two invited papers presenting an overview of the topic of the section. Contributed papers follow reporting the results of experimental studies and theoretical analyses of related specific topics. This book will contribute to a better understanding and efficient control of the soil environment.
Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Download or read book Science of Advanced LMFBR Fuels written by Hj Matzke and published by North Holland. This book was released on 1986 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Machine Learning and Data Mining written by Ryszad S. Michalski and published by Wiley. This book was released on 1998-04-22 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the new computational tools to get the most out of your information system. This practical guide, the first to clearly outline the situation for the benefit of engineers and scientists, provides a straightforward introduction to basic machine learning and data mining methods, covering the analysis of numerical, text, and sound data.
Download or read book Bioenergetics 2 written by David G. Nicholls and published by Academic Press. This book was released on 2014-06-28 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioenergetics 2 aims to clarify topics such as the thermodynamics of bioenergetic processes and the stoichiometries of energy coupling reactions. The book discusses chemiosmotic energy transduction; ion transport across energy-conserving membranes; and quantitative bioenergenetics as the measurement of driving forces. The text also describes the chemiosmotic proton circuit; the respiratory chain; the photosynthetic generators of protonmotive force; and the ATP synthase. The secondary transport of products across the membrane, as well as the structures of the bacterial photosynthetic reaction center and bacteriorhodopsin are also considered. Biochemists will find the book invaluable.
Download or read book Neuronal Development and Degeneration written by Wenbo Zhang and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cadmium and Health written by Lars T. Friberg and published by CRC Press. This book was released on 2019-06-27 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 1986: Volume 2: Effects and Response, is primarily devoted to the toxicology of cadmium and includes effects on the respiratory system, kidneys, and bone as well as other toxic effects, including those from the hemaopoietic and cardiovascular system, the liver, the reproductive organs, and the fetus.
Download or read book False River written by Dominique Botha and published by . This book was released on 2014-04 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Paul and Dominique are sent to boarding schools, their idyllic childhood on a South African farm is over. Their parents' leftist politics has made life impossible in the local town school. Angry schoolboy Paul is a promising poet, his sister his confidante. But his literary awakening turns into a descent. He flees the oppression of South Africa, only to meet his death in London. Dominique Botha's poignant debut is an elegy to a rural existence and to her brother - both now forever lost. The novel is based on true events.
Download or read book Mitochondria written by V. M. Darley-Usmar and published by Oxford University Press, USA. This book was released on 1987 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondriais a unique and comprehensive guide to the key techniques used in both enzymology and molecular biology studies. Some of the protocols described in this book are well-established but, until now, have been scattered amongst enzymology manuals and biochemistry research journals. Other techniques are described in detail for the first time.
Download or read book Intercellular Communication through Gap Junctions written by Y. Kanno and published by Newnes. This book was released on 1995-02-09 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on intercellular communication through gap junctions has continued to expand, and the meeting on which this book is based brought together many scientists from many different countries and disciplines. In line with the objective of the meeting, this volume focuses on the biological meaning of intercellular communication through gap junctions in various organs. The most recent up-to-date findings have been included in this extensive volume, valuable to all those interested in this rapidly expanding field.
Download or read book Diversity and Difference in South African Schools written by Annamagriet De Wet and published by . This book was released on 2018 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by Oxford University Press. This book was released on 2015 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
